Fascioliasis

Mas‐Coma, Santiago; Valero, M. Adela; Bargues, M. D.

doi:10.1007/978-1-4939-0915-5_4

Cited by 81 publications

(53 citation statements)

References 114 publications

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“…By contrast, close phylogenetic relatives including the minute intestinal flukes such as Haplorchis taichui , which reside in the human intestines, do not cause cancer [69, 70]. Similarly, infection with the better-known liver flukes Fasciola hepatica and F. gigantica does not appear to cause liver cancer [71]. Notably, the hepato-intestinal schistosomes of humans, S. japonicum and S. mansoni , do not cause cancer.…”

Section: Organotropism and Cancermentioning

confidence: 99%

Why Does Infection With Some Helminths Cause Cancer?

2015

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Infections with Opisthorchis viverrini, Clonorchis sinensis and Schistosoma haematobium are classified as Group 1 biological carcinogens: definitive causes of cancer. These worms are metazoan eukaryotes, unlike the other Group 1 carcinogens including human papilloma virus, hepatitis C virus, and Helicobacter pylori. By contrast, infections with phylogenetic relatives of these helminths, also trematodes of the phylum Platyhelminthes and major human pathogens, are not carcinogenic. These inconsistencies prompt several questions, including how might these infections cause cancer? And why is infection with only a few helminth species carcinogenic? Here we present an interpretation of mechanisms contributing to the carcinogenicity of these helminth infections, including roles for catechol estrogen- and oxysterol-metabolites of parasite origin as initiators of carcinogenesis.

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Section: Organotropism and Cancermentioning

confidence: 99%

Why Does Infection With Some Helminths Cause Cancer?

2015

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“…Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries [1, 2]. In the world, it has been estimated that at least 2.6 million people are affected with this disease [3].…”

Section: Introductionmentioning

confidence: 99%

Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells

Ferreira

Fernandes

Botelho

2018

AIA

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Background Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis, also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by F. hepatica has not been associated with cancer to date. There are not any known causative associations between this parasite and liver cancer (cholangiocarcinoma). Methods Chine Hamster Ovary (CHO) cells were treated with F. hepatica extracts and cell proliferation was assessed by using the indirect method for estimating cell number based on the mitochondrial activity with MTS cell proliferation reagent. We observed unexpected death of these cells when treated with F. hepatica extracts. Results We now hypothesize that this parasite could be used as a medically-important trematode pathogen in cancer therapy.

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“…Fascioliasis, one of the major veterinary parasitic diseases in ruminants, such as cattle, sheep, and goats, causes economic losses in animal husbandry [1,2]. Human fascioliasis has been ignored for a long time until the last decade, when this zoonotic infection emerged or reemerged in more than 60 countries [3,4].…”

Section: Introductionmentioning

confidence: 99%

Human Cases of Fascioliasis in Fujian Province, China

Cai

et al. 2017

Korean J Parasitol

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Fascioliasis is a foodborne zoonotic parasitic disease. We report 4 cases occurring in the same family, in whom diagnosis of acute fascioliasis was established after series of tests. One case was hospitalized with fever, eosinophilia, and hepatic lesions. MRI showed hypodense changes in both liver lobes. The remaining 3 cases presented with the symptom of stomachache only. Stool analysis was positive for Fasciola eggs in 2 adult patients. The immunological test and molecular identification of eggs were confirmed at the National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China. The results of serological detection were positive in all the 4 patients. DNA sequencing of PCR products of the eggs demonstrated 100% homology with ITS and cox1 of Fasciola hepatica. The conditions of the patients were not improved by broad-spectrum anti-parasitic drugs until administration of triclabendazole.

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Fascioliasis

Cited by 81 publications

References 114 publications

Why Does Infection With Some Helminths Cause Cancer?

Why Does Infection With Some Helminths Cause Cancer?

Fasciola Hepatica Extract Induces Cell Death of Mammalian Cells

Human Cases of Fascioliasis in Fujian Province, China

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