We compared the indicators of leukogram and ESR in the second year of the COVID-19 pandemic (2021) among employees of two institutions: SF "Peremoga Nova" Poultry Farm (15 people) and the State Fire and Rescue Squad (22 people). The workers of the poultry farm showed certain signs of the development of pro-inflammatory processes (an increase in the level of monocytes and ESR). Such signs are absent in the employees of the fire and rescue squad, which allows us to consider the conditions of professional activity as the main etiological factor of the identified trends. Emotional stress caused by the COVID-19 pandemic could be an additional trigger for the identified trends.