Neurological complications of coeliac disease

Tengah, Dayangku Siti Nur Ashikin Pengiran; Wills, Adrian; Holmes, G. K. T.

doi:10.1136/pmj.78.921.393

Cited by 61 publications

(24 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of these types of complications seems to be increasing in celiac population [43]. The absence of these complications could therefore be related to a different mechanisms than simple gluten toxicity, such as different genetic susceptibility.…”

Section: Discussionmentioning

confidence: 98%

Complications in Celiac Disease Under Gluten-Free Diet

et al. 2008

View full text Add to dashboard Cite

We assessed the onset of malignant and nonmalignant complications in a cohort of celiac disease (CD) patients under gluten-free diet (GFD). Five hundred and forty-nine CD patients were retrospectively assessed. Two hundred and fifty-one (45.7%) showed classical, 262 (47.7%) subclinical, and 36 (6.6%) silent form of CD at the time of the diagnosis. The mean time under GFD was 7.13 years (range 1-15 years). Out of 549 patients, 381 (69.4%) were fully compliant, 112/549 (20.4%) reported less than one dietary transgression/month, and 56/549 (10.2%) reported at least one dietary transgression/month. Out of 549 patients, 18 (3.3%) patients developed complications under GFD (seven malignant and 11 nonmalignant complications). Fourteen patients were previously affected by classical CD (5.6% of the overall patients with classical CD), and four were affected by subclinical CD (1.5% of the overall patients with subclinical CD). None of the patients affected by silent CD developed complications. There was no statistical difference between the mean age of the two groups developing complications (P = n.s.). Complications appeared after a mean time under GFD of 6.5 years in classical CD, and after a mean time of 3.5 years in subclinical CD (P = n.s.). Finally, 6/14 (42.8%) patients with classical CD were not fully compliant to GFD, while 2/4 (50%) of subclinical CD patients were not fully compliant to GFD (P = n.s.). Less than 5% of CD patients may develop complications under GFD. Complications seem to affect more classical CD than subclinical CD, and seem to be irrespective of optimal GFD adherence.

show abstract

Section: Discussionmentioning

confidence: 98%

Complications in Celiac Disease Under Gluten-Free Diet

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Evidence of a positive association between CD and subsequent polyneuropathy is conflicting, 20, 23–26 although there are several reports of polyneuropathy prior to a diagnosis of CD 17, 27–29 . Recent case series do however indicate a link between CD and neuropathy 21, 22, 30, 31 and Brannagan et al.…”

Section: Introductionmentioning

confidence: 99%

A population‐based study of coeliac disease, neurodegenerative and neuroinflammatory diseases

Ludvigsson

Olsson

Ekbom

et al. 2007

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…However, because improvement of symptoms has rarely been observed with vitamin therapy, and hypovitaminosis is not always present in CD patients, this hypothesis is insufficient [17][18][19]. Moreover, even in CD patients with severe vitamin deficiencies, neurologic abnormalities are not often detected [20,21].…”

Section: Discussionmentioning

confidence: 99%