Neurological disorders in patients with long COVID syndrome and cell therapy methods for their correction a literature review

Долгополов, И. С.; Менткевич, Г. Л.; Rykov, M. Yu.; Chichanovskaya, L. V.

doi:10.47093/2218-7332.2021.12.3.56-67

Cited by 7 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anxiety, depression, panic attacks, and sleep disturbances are frequently encountered as prevailing affective disorders among patients and individuals in the recovery phase of COVID-19 [91]. Alongside the aforementioned conditions, Mazza et al [92] have documented cases of post-traumatic stress disorder and symptoms of obsessive-compulsive disorder during the pandemic.…”

Section: Mental Disordersmentioning

confidence: 99%

“…Gastrointestinal symptoms involve anorexia, abdominal pain, dyspepsia, and diarrhea. COVID-19 survivors may also experience long-lasting or newly developed skin conditions such as itching, hives, hair loss, and fibromyalgia [84,91]. A meta-analysis by Alkodaymi et al [100] revealed substantial heterogeneity among studies regarding the prevalence of all documented symptoms.…”

Section: Post-covid Syndromementioning

confidence: 99%

See 1 more Smart Citation

Factors affecting the severity of COVID-19 and the development of complications

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

View full text Add to dashboard Cite

Due to the prevalence and diversity of both symptoms and outcomes of COVID-19, understanding the factors that determine the risk of the severe course of this disease and its possible complications is of particular importance. In this review, we present the information on the specifics of COVID-19 pathogenesis and give a theoretical justification for the factors that determine the course of this disease in patients of different age groups, patients with chronic pathology, and pregnant women. Particular attention is paid to the post-COVID syndrome.

show abstract

Section: Mental Disordersmentioning

confidence: 99%

Section: Post-covid Syndromementioning

confidence: 99%

Factors affecting the severity of COVID-19 and the development of complications

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

View full text Add to dashboard Cite

show abstract

Acute and long-term neurological disorders in patients with coronavirus infection

Parfenov

Кулеш

2022

RJTAO

View full text Add to dashboard Cite

Currently, patients who attribute their complaints and disorders to the past COVID-19 are turning to a neurologist for a consultation. One should consider dangerous complications of COVID-19 such as stroke, including cerebral venous thrombosis, autoimmune encephalitis and myelitis, posterior reversible encephalopathy syndrome, Guillain–Barre’ syndrome. Disorders of consciousness, disorders of smell and taste, headache and dizziness are significantly more often present in the acute period of COVID-19. Long-term persistence of complaints and disorders after COVID-19 is regarded as post-COVID syndrome (PCS). Neurological complaints and disorders in a patient who has had COVID-19 are often caused by the development or exacerbation of a comorbid disease, including primary headache, musculoskeletal pain in the neck and back, various vestibular disorders, Alzheimer's disease, anxiety and depressive disorders. Unfortunately, in real clinical practice, these diseases are often not diagnosed, patients are observed with a diagnosis of PCS, and it is not taken into account that the basis for diagnosing PCS is the exclusion of other diseases that can explain complaints and disorders in a patient who has suffered from COVID-19.

show abstract

Clinical case of rhino-orbital mucormycosis in a convalescent COVID-19 patient: diagnostic and treatment tactics

Popova

Demina

Zaytseva

et al. 2022

Russian Journal of Infection and Immunity

View full text Add to dashboard Cite

According to current data, SARS-CoV-2 virus has the ability to cause multi-organ pathology, leading to acute damage of various organs and systems and long-term consequences characterized by polymorphic symptoms. Recently, a high incidence of invasive mycoses, particularly mucormycosis COVID-M, has been noted among the COVID-19 complications. The predisposing factor for the development of this pathology is diabetes mellitus, immunodeficiency states, and prolonged use of high doses of glucocorticosteroids. Mucormycosis is characterized by severe clinical manifestations and high lethality, and timely diagnostics of this pathology often represents a difficult problem. The aim of this study was to analyze a clinical case of rhino-orbital mucormycosis in convalescent COVID-19 patient. In the study, there was used mucopurulent nasal discharge from the patient previously hospitalized with a severe novel coronavirus infection. Here, we describe the methodology allowing to isolate and identify a pure mold fungus culture from the biomaterial using methods of routine bacteriology and MALDI-ToF mass spectrometry. Direct microscopy examination of nasal cavity discharge revealed branched non-septic hyphae with a characteristic branching angle, allowing to preliminarily diagnose invasive mucormycosis. Growth of mycelial fungus colony was observed by using Sabourauds medium with potassium tellurite. Microscopy of the pure culture revealed branching mycelium without septa, broad, with irregular thickness, unsegregated hyphae, and sporangia with a typical column specific to mucormycetes. Analysis of the obtained mass spectra allowed to establish the microbial species identity as Lichtheimia corymbifera. The latter along with other members of the order Mucorales, are known to cause mucormycosis. As a result of antifungal treatment (Amphotericin B) and timely surgical intervention, the patient was discharged from the hospital with prominent clinical improvement and no complaints during further outpatient follow-up period. The analysis of this clinical case showed the lack of alertness in some clinical diagnostic laboratories to detect pathogens of invasive mycoses. To avoid errors, while making a diagnosis, attention should be paid not only to detection of fungal spores in clinical material, but also take into account the structure of mycelium underlying major difference between yeast-like fungi, higher and lower molds. The isolation and identification of a pure pathogen culture allows to confidently verify the diagnosis, timely correct the treatment tactics and monitor circulation of mycotic agents to prevent occurrence of mycoses in most vulnerable patients cohorts.

show abstract

Neurological disorders in patients with long COVID syndrome and cell therapy methods for their correction a literature review

Cited by 7 publications

References 63 publications

Factors affecting the severity of COVID-19 and the development of complications

Factors affecting the severity of COVID-19 and the development of complications

Acute and long-term neurological disorders in patients with coronavirus infection

Clinical case of rhino-orbital mucormycosis in a convalescent COVID-19 patient: diagnostic and treatment tactics

Contact Info

Product

Resources

About