Neurological manifestations of human leishmaniasis

Llanos-Cuentas, Alejandro; Valencia, Braulio M.; Petersen, Christine A.

doi:10.1016/b978-0-444-53490-3.00013-3

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…This patient, presenting abnormal movements characterized by tremors in the hands and head, and myoclonic movements on his face, showed a diffuse reduction of the frontal lobes and cerebral atrophy in brain images analyses . Other few well‐documented reports refer mainly to meningoencephalitis and ocular manifestations . In fact, a study with VL patients from East Africa reported that parasites disseminate into the CNS, mainly into brain meninges, the cerebrospinal fluid (CSF) and the endothelia of meningeal vessels, but are resolved after pentavalent antimony therapy .…”

Section: Neurological Alterations In Human Visceral Leishmaniasismentioning

confidence: 82%

“…In this active form of the disease, the parasite affects primarily organs that contain cells of the mononuclear phagocyte system, residing mainly within macrophages of the liver, spleen and bone marrow. Moreover, some authors have reported the involvement of the peripheral and central nervous systems (CNS) in patients with leishmaniasis .…”

Section: Epidemiological and Clinical Features Of Leishmaniasismentioning

confidence: 99%

“…In patients with leishmaniasis, the occurrence of peripheral neuropathy is more common than manifestations related to the CNS. Recently, Llanos‐Cuentas and colleagues summarized the main neurological damage found in patients with cutaneous and VL as being (i) peripheral demyelinating immune‐mediated neuropathy in VL, (ii) peripheral neuropathy in CL due to direct or close parasite involvement with the nerve or nerve sheath, (iii) CNS involvement by haematogenous dissemination in VL or close contiguity in ML, and (iv) neuropathy associated with leishmanicidal treatments.…”

Section: Clinical Features Of Human Neurological Leishmaniasismentioning

confidence: 99%

See 2 more Smart Citations

Neurological disease in human and canine leishmaniasis – clinical features and immunopathogenesis

Maia

Monteiro

Gavioli

et al. 2015

Parasite Immunology

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Leishmaniasis is a vectorborne disease caused by Leishmania protozoa, which is a major health problem and a neglected disease common in many regions of the world. Leishmania is an intracellular parasite transmitted by sand flies that causes clinical manifestations ranging from a severe and potentially fatal disease named visceral leishmaniasis to less severe but in many cases disfiguring diseases that mainly affect the skin or mucosal tissues, known as cutaneous leishmaniasis. Despite the detection of Leishmania parasites in the brain and cerebrospinal fluid of human patients and dogs, epidemiological data, as well as information about the mechanisms of central and peripheral nervous system alterations, are poorly described. This review is focused on the current knowledge about the neurological manifestations and immunopathogenic mechanisms in human patients and animals infected with Leishmania.

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Section: Neurological Alterations In Human Visceral Leishmaniasismentioning

confidence: 82%

Section: Epidemiological and Clinical Features Of Leishmaniasismentioning

confidence: 99%

Section: Clinical Features Of Human Neurological Leishmaniasismentioning

confidence: 99%

See 1 more Smart Citation

Neurological disease in human and canine leishmaniasis – clinical features and immunopathogenesis

Maia

Monteiro

Gavioli

et al. 2015

Parasite Immunology

View full text Add to dashboard Cite

show abstract

“…and can be forgotten 4 . Llanos-Cuentas et al proposed that "in patients from Leishmania-endemic areas, when observing neurological symptoms, causation secondary to infection with Leishmania spp.…”

mentioning

confidence: 99%

“…Llanos-Cuentas et al proposed that "in patients from Leishmania-endemic areas, when observing neurological symptoms, causation secondary to infection with Leishmania spp. may be considered 4 . " Focusing on the new species infection from Thailand, there has never been information regarding neurological manifestation.…”

mentioning

confidence: 99%