Neurological Manifestations of Hypoglycemia

Jordan, William R.

doi:10.1056/nejm193310122091501

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…Patients suffering from recurrent hypoglycemia develop symmetric distal sensorimotor neuropathy including the following symptoms: numbness, weakness, muscle atrophy in both hands and feet, difficulty in walking, and painful distal paresthesiae with or without sensory loss (Jordan, 1933;Williams, 1955;Jaspan et al, 1982;Jayasinghe et al, 1983;Tintore et al, 1994;Puri et al, 2000). Patients suffering from recurrent hypoglycemia develop symmetric distal sensorimotor neuropathy including the following symptoms: numbness, weakness, muscle atrophy in both hands and feet, difficulty in walking, and painful distal paresthesiae with or without sensory loss (Jordan, 1933;Williams, 1955;Jaspan et al, 1982;Jayasinghe et al, 1983;Tintore et al, 1994;Puri et al, 2000).…”

Section: Neurophysiologic Observationsmentioning

confidence: 99%

Neurologic damage in hypoglycemia

Mohseni

2014

Handbook of Clinical Neurology

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Section: Neurophysiologic Observationsmentioning

confidence: 99%

Neurologic damage in hypoglycemia

Mohseni

2014

Handbook of Clinical Neurology

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“…In IDDM and NIDDM patients efforts to normalize the blood glucose level through administration of exogenous insulin or other drugs, such as sulfonylurea, may cause hypoglycemic episodes [36,50,54,62,67,80,95,118,135]. Patients with a tight glycemic control suffer a greater risk of having hypoglycemic episodes than do patients with a more or less chronic hyperglycemic state [34,77,128,129].…”

Section: Hypoglycemic Neuropathy Caused By Administration Of Insulin mentioning

confidence: 99%

“…Several reports describe patients with paralysis following hypoglycemia [67], but it is not clear whether these paralytic states were due to PNS or CNS alterations. The clinical and pathological picture indicated the presence of a severe sensory-motor neuropathy.…”

Section: Observations In Human Beingsmentioning

confidence: 99%

Hypoglycemic neuropathy

Mohseni

2001

Acta Neuropathol

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Hypoglycemia is a relatively common condition primarily affecting diabetic patients treated with insulin or other hypoglycemic drugs and insulinoma patients. Clinical experience and experimental studies show that hypoglycemia may cause alterations both in the central (CNS) and the peripheral (PNS) nervous system. Hypoglycemic effects on the CNS include various symptoms such as irritability and lack of concentration, disruption of cognitive functions, convulsions and unconsciousness. As for pathology, a loss of neurons has been noted, being more obvious in the cerebral cortex and the hippocampus than in the brain stem, cerebellum and spinal cord. Myelin damage and glial changes have also been observed in the CNS. The development of pathological changes in the brain has mainly been studied on autopsy material from patients who died in insulin coma and in animals exposed to a severe hypoglycemia and showing an isoelectric electroencephalogram. It has been suggested that hypoglycemic loss of neurons in the brain is related to excititoxic actions of aspartate on N-methyl-D-aspartate receptors. With respect to the PNS, scattered clinical observations in humans and experimental studies in animals show that hypoglycemia causes a distal axonopathy including both degenerative and regenerative events. In this respect, motor axons seem to be more vulnerable than sensory axons. Animal experiments show that a peripheral neuropathy may develop even in cases with a mild hypoglycemia compatible with a generally normal behavior. The cellular mechanisms behind the development of hypoglycemic PNS alterations are unknown. To elucidate the pathophysiology of hypoglycemic neuropathy more basic research is needed.

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Paralysis of the Bladder in Diabetic Patients

Jordan¹

1935

Arch Intern Med

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Neurological Manifestations of Hypoglycemia

Cited by 9 publications

References 16 publications

Neurologic damage in hypoglycemia

Neurologic damage in hypoglycemia

Hypoglycemic neuropathy

Paralysis of the Bladder in Diabetic Patients

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