Neurological Sequelae in Children Surviving Mechanical Ventilation in the Neonatal Period

Marriage, K. J.; Davies, Pamela

doi:10.1097/00006254-197710000-00013

Cited by 5 publications

(5 citation statements)

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“…The total incidence of 16% was comparable to the findings of others (8, 9, 13). Like others we found no difference in survival or sequelae rate between patients born in Lund and patients referred from other hospitals (3,13,21). Two factors may have contributed to this: 1) Many highrisk pregnant women were referred to our Maternity hospital prior tb delivery so that these infants influenced the results of the patients born in Lund.…”

Section: Discussionsupporting

confidence: 78%

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: II. Pulmonary and neuro‐developmental sequelae in relation to original diagnosis

et al. 1980

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The incidence of bronchopulmonary dysplasia (BPD) and neuro-developmental sequelae in 135 infants surviving intermittent positive pressure ventilation (IPPV) in the newborn period were studied in relation to primary disorders requiring IPPV. The rate of BPD increased over the 6-year study period in hyaline membrane disease survivors from 14% to 28%, but decreased in infants with apnoea repetens from 38% to 13%. Immaturity seemed to be one important factor for development of BPD. The incidence of neuro-developmental sequelae in IPPV treated infants fell from 22% to 13% over the years. In infants with birth weight below 1501 g the rate of neurological handicaps was 11%.

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Section: Discussionsupporting

confidence: 78%

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: II. Pulmonary and neuro‐developmental sequelae in relation to original diagnosis

et al. 1980

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“…However, lung function studies by Coates et al (1977), which compared our group of children with controls, showed persistent small-airway dysfunction at school age. 6 per cent of the children in our study were asthmatic, compared with 11 per cent in the study by Marriage and Davies (1977).…”

Section: Discussioncontrasting

confidence: 57%

Outcome at School‐age After Neonatal Mechanical Ventilation

Gunn

Lepore

Outerbridge

1983

Develop Med Child Neuro

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SUMMARY 103 school‐age children (5 to 12 years) who survived mechanical ventilation for neonatal respiratory failure were evaluated for growth, neurological, intellectual, psychological and school function in order to determine those children most at risk for handicap. A major handicap occurred in seven children, preventing attendance at normal school or normal classes. Neurological sequelae were significantly associated with perinatal asphyxia and with birthweights of 1500g or less, and neurological sequelae and socio‐economic factors were the major determinants of ability. The effects of the Neonatal Intensive Care Unit (NICU) experience on parents and subsequent parent‐child relationships were also investigated: 67 per cent of the mothers were very upset by the experience and many continue to worry excessively about the health of their child. Parents who visited their child in the NICU frequently were significantly more anxious and overprotective, restricting many activities even when the child was of school age. RÉSUMÉ Survivants aprés ventilation mécanique néo‐natale: leur devenir à l'âge scolaire 103 enfants d'âge scolaire (cinq à 12 ans) ayant survécu après ventilation mécanique pour dêfaut respiratoire néo‐natal ont étéévalués sur la croissance, les fonctions neurologiques, intellectuelles, psychologiques et scolaires en vue de déterminer ceux de ces enfants présentant le plus de risque de handicaps. Un handicap majeur survint chez sept enfants empêchant la fréquentation d'une école normale ou de classes normales. Les séquelles neurologiques étaient significativement associées à une asphyxie périnatale, à un poids de naissance inférieur ou égal à 1500g et les séquelles neurologiques et les facteurs socio économiques étaient les déterminants majeurs de capacité. Les effects d'une expérience d'unité de soins intensifs péri‐néo‐nataux (USIP) sur les parents et les relations ultérieures parents‐enfants ont également étéétudiés. 67 pour cent des méres étaient trés contrariées par cette expérience et beaucoup ont continuéà s'inquiéter à l'excés sur la santé de leur enfant. Les parents ayant fréquemment rendu visite à leur enfant dans l'USIP étaient significativement plus anxieux et surprotecteurs, restreignant de nombreusess activités une fois l'enfant à l'âge scolaire. ZUSAMMENFASSUNG Untersuchungsbefunde von Schulkindern, die in der Noenatalperiode beatmet worden waren 103 Schulkinder (von fünf bis 12 Jahren), die in der Neonatalperiode wegen eines respiratorischen Versagens beatmet worden waren, wurden hinsichtlich ihres Wachstums, ihres neurologischen, intellektuellen und psychologischen Befundes und ihres Schulverhaltens beurteilt, um die Kinder herauszufinden die am wahrscheinlichsten das Risiko einer Behinderung haben. Sieben Kinder waren deutlich behindert, so daß sie keine normale Schule oder’ normalen Unterricht besuchen konnten. Die neurologischen Folgen standen in signifikantem Zusammenhang mit perinataler Asphyxie und einem Geburtsgewicht unter 1500g, und die neurologischen Folgen und sozioökonomis...

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“…Diplegia may no longer be the most common type of CP among survivors of neonatal intensive care (Marriage and Davies 1977). 38 per cent of LBW infants with CP in our population had hemiplegia.…”

Section: Discussionmentioning

confidence: 69%

Cerebral Palsy in Low‐birthweight Infants. I. Spastic Hemiplegia: Associations With Intrapartum Stress

Powelr¹,

Pharolah

Cooke

et al. 1988

Develop Med Child Neuro

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Children with and without spastic hemiplegia were identified among a representative sample of 1048 low-birthweight survivors by clinical assessment after three years of age. The hypothesis that hemiplegia was predetermined at birth was tested by estimating the probability of hemiplegia for each infant by logistic regression analysis, using data from hospital records on conditions known at the time of birth. 16 of 42 children with cerebral palsy had spastic hemiplegia. Allowing for the lower birthweights of hemiplegic children, increased prevalence was associated with previous reproductive loss, breech vaginal delivery, later birth-order, prolonged second stage of delivery, emergency caesarean section, and low Apgar scores. These variables identified correctly most children as having a higher or lower estimated probability of hemiplegia. Hemiplegia was also associated with prolonged respiratory disease and intraventricular haemorrhage. In this population it is likely that intrapartum events were closely related to the pathogenesis of hemiplegia; their effects may have been mediated by postnatal events.

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Neurological Sequelae in Children Surviving Mechanical Ventilation in the Neonatal Period

Cited by 5 publications

References 0 publications

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: II. Pulmonary and neuro‐developmental sequelae in relation to original diagnosis

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: II. Pulmonary and neuro‐developmental sequelae in relation to original diagnosis

Outcome at School‐age After Neonatal Mechanical Ventilation

Cerebral Palsy in Low‐birthweight Infants. I. Spastic Hemiplegia: Associations With Intrapartum Stress

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