Neurological soft signs in chronic schizophrenic patients: Clinical correlates

Bartkó, György; Zádor, György; Horvath, Szabolcs; Herczeg, Ilona

doi:10.1016/0006-3223(88)90185-0

Cited by 22 publications

(8 citation statements)

References 10 publications

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“…These findings may support the prognostic values of both NSS and negative symptoms in the evaluation of schizophrenic condition. SANS The mean age of the patients in this study which is 38.19 is higher than in the previous study of Rossi et al (1990), which was 34.82, but is lower than the study of Bartko et al (1988), which was 41.30. The clinical diagnosis of chronic schizophrenic patients, covered various types : paranoid schizophrenics…”

Section: Discussioncontrasting

confidence: 73%

Correlation of neurological soft signs and negative symptoms in chronic schizophrenic patients

Elvira

Salan²

1996

Med J Indones

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Neurological SoTt Srgrae (NSS) banyak diju.npai pada pasien-pasien skizofretria yang kronis dibandingkan dengan yang akut. Gejala negatif, telah lana diketahui nrerupakan sekwnpulan gejala yang juga lebih banyak dijunpai pada pasien-pasien skizofrenia kronis. Keduakclonrpokgejalatersebut, dalanr dua dekade terakhir ini, diketahui sebagai gejala-gejala),ang ilrcncer,,tinkan terdapatnl,a kelainan organik pada otak. Tuiuan penelitian ini ialah nengeîahui hubungan antara kcdua kelotupok gejala tersebut pada pasietr skizofrenia kronis, khususnya di ru.nah sakit Dr. Cipto Mangunkusurtro dan Runah Sakit JiwaJakarra, rcntpat penelitian ini dilaksanakan (Desenber 1991 hinggaApril 1992). Padapenelitian ini dilakukan peneriksaan klinikpsikiatrik, peneriksaan skor gejala negatifdengan nenggunakan instrwnen SANS dan peneriksaan neurologik unruk NSS terhadap 2I prtsien skizofrenia kronis sebagai kasus dan 2I pasien skizofrenia akut (skizofrenifortn) sebagai kelola. Sepuluh orang pasien skizofrenia kronis diperiksa oleh interrater unruk skor SANS dan 1l pasien skizofrenia kronik lainnl,a untuk penteriksaan NSS. Ternyata didapatkan bahwa pada pasien skizofrenia kronis (teruta,na yang lebih dari 1O tahun), terdapat hubungan yang bennakna antara NSS dan gejala negatif (0.87). Dari penelitian ini diperoleh pula bahwa NSS lebih sering dijuntpai pada pasien skizofrenia kronis daripada skizofrenifonn; dengan denikian bila NSS dijutnpai pada pasien skizofreniform dan skornya cukup tittggi, dapat nerupakan petwluk prediktif bahv,a pasien tersebut ternasuk),ang cenderutrg nerjadi kronis (Tipe II-Crow).

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Section: Discussioncontrasting

confidence: 73%

Correlation of neurological soft signs and negative symptoms in chronic schizophrenic patients

Elvira

Salan²

1996

Med J Indones

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“…In the present study, we have strictly matched the two groups according to age, because previous studies on age‐specific NSS level differences in schizophrenia showed contradictory results (Bombin, Arango, & Buchanan, ): While the majority of earlier studies could not identify any effects of age on NSS scores in SZ (Bartko, Zador, Horvath, & Herczeg, ; Buchanan & Heinrichs, ; Lane et al, ; Mohr et al, ), a number of studies showed that NSS levels might increase with age suggesting a progressive worsening of sensorimotor functioning (Cuesta, Peralta, & de Leon, ; Griffiths, Sigmundsson, Takei, Rowe, & Murray, ; Herold et al, ). Further, our study did not include duration of illness (DOI) as a covariate in the statistical analyses, because the question whether NSS are early markers of motor dysfunction preceding the illness onset or consequences of progressive worsening are not conclusively clarified yet.…”

Section: Methodsmentioning

confidence: 99%

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

Hirjak

Rashidi

Fritze

et al. 2019

Human Brain Mapping

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Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co‐altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right‐handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion technique for multimodal MRI data—multiset canonical correlation and joint independent component analysis (mCCA + jICA)—to investigate co‐altered patterns of GMV and intrinsic neural fluctuations (INF) in SSD patients exhibiting NSS. The mCCA + jICA model indicated two joint group‐discriminating components (temporoparietal/cortical sensorimotor and frontocerebellar/frontoparietal networks) and one modality‐specific group‐discriminating component (p < .05, FDR corrected). NSS motor score was associated with joint frontocerebellar/frontoparietal networks in SSD patients. This study highlights complex neural pathomechanisms underlying NSS in SSD suggesting aberrant structure and function, predominantly in cortical and cerebellar systems that critically subserve sensorimotor dynamics and psychomotor organization.

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“…[ 12 ] and Chen et al . ;[ 13 ] however, some other studies[ 7 14 15 ] conducted across various places have not found any association between age and NSS.…”

Section: Discussionmentioning

confidence: 96%

“…Similarly, gender has consistently been shown not to introduce variance in the presence and severity of NSS, with most of the studies. [ 7 14 16 17 ] Although Heinrichs and Buchanan[ 3 ] in their review found increased NSSs in male patients with schizophrenia, NSS tended to increase over a period of 5 years during follow-up and this increase was predominantly in males. As described in a study by McNeil et al .,[ 18 ] this maybe because “males were more likely to have been subjected to maternal obstetric complications and were more likely to have a nonremitting course of illness.”…”

Section: Discussionmentioning

confidence: 99%

A clinical study of neurological soft signs in patients with schizophrenia

Dutta

Nath

Baruah

et al. 2016

Journal of Neurosciences in Rural Practice

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Background and Aim:Neurological soft signs (NSSs) are “objectively measured, nonlocalizing abnormalities, not related to impairment of a specific brain region, reflecting improper cortical-subcortical and intercortical connections.” The possibility of NSS as an endophenotype in schizophrenia has been studied across the globe. We aimed at finding the prevalence of NSS among patients with schizophrenia as well as the associations of NSS between various sociodemographic and illness variables.Subjects and Methods:One hundred patients between the age group of 16 and 60 years were serially selected from the inpatient department of a tertiary care hospital who have been diagnosed as a case of schizophrenia according to the International Classification of Diseases version 10 during 1 year period. A semi-structured pro forma was used to collect various demographic as well as illness data, and subjects were clinically evaluated for NSS using neurological evaluation scale.Results:The prevalence of NSSs was found to be 67%, significant association was found between NSS and age, occupation, and duration of illness. A statistically significant correlation was found between NSS and age, NSS and duration of illness.Conclusion:The validity of NSS as an endophenotype lies in the fact that it should be independent of all sociodemographic and illness variables. However, our study evaluated some statistically significant findings between them. Hence, further researches are required with properly adjusted controls to find if the associations obtained between NSS and different variables here are true or whether there are some confounding factors included.

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Neurological soft signs in chronic schizophrenic patients: Clinical correlates

Cited by 22 publications

References 10 publications

Correlation of neurological soft signs and negative symptoms in chronic schizophrenic patients

Correlation of neurological soft signs and negative symptoms in chronic schizophrenic patients

Patterns of co‐altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders

A clinical study of neurological soft signs in patients with schizophrenia

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