Neurological Syndromes Associated With Carcinoma the Carcinomatous Neuromyopathies

Brain, Russell; Henson, R. A.

doi:10.1016/s0140-6736(58)90471-9

Cited by 142 publications

(40 citation statements)

References 13 publications

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“…Brain and Henson (1958) coined the term ' carcinomatous neuromyopathy ' to describe such lesions, which included peripheral sensorimotor neuropathy as well as many other neurological disorders.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of seminoma of the testis

Evans

Kaufman

1971

Journal of British Surgery

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Section: Discussionmentioning

confidence: 99%

Unusual presentation of seminoma of the testis

Evans

Kaufman

1971

Journal of British Surgery

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“…Different patterns of neurological involvement have been distinguished (Brain and Norris, 1964;Joynt, 1974;Croft, 1977), but there is considerable overlap (Brain and Henson, 1958). Peripheral neuropathies and myopathy are recognized more frequently than CNS manifestations, and cerebellar degeneration is the most frequent central disturbance (Joynt, 1974;Vick et al, 1969).…”

Section: Discussionmentioning

confidence: 99%

“…In some instances, the ectopic production of hormones and hormone-like substances has been shown to be responsible but, in others, no cause was found. Neurological lesions are particularly common (Brain and Norris, 1964;Joynt, 1974;Croft, 1977;Brain and Henson, 1958;Vick, Schulman and Dau, 1969;Brain and Wilkinson, 1965;Croft and Wilkinson, 1965;Henson, 1970), and various clinical syndromes have been described. Peripheral neuropathy accompanying bronchial carcinoma is the most frequently recognized neurological lesion but subacute cerebellar degeneration which may accompany a variety of tumours is also well recognized, and a combination of central and peripheral lesions may be seen.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar cortical degeneration with ovarian carcinoma

Steven

Mackay

Carnegie

et al. 1982

Postgraduate Medical Journal

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A case is described of progressive cerebellar degeneration in association with ovarian carcinoma, with nearly 4 years elapsing between the onset of neurological illness and the discovery of the carcinoma. Neither treatment with prednisolone nor surgical removal of the tumour effected any improvement, CAT scanning late in the illness showed marked cerebellar atrophy. Histology at post-mortem showed complete loss of cerebellar Purkinje cells. The cerebrospinal fluid gave weak binding to multiple neural components in a solid-phase radio-immuno-assay.

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“…Paraneoplastic neuromuscular disorders are defined as remote effects of cancer not related to treatment or to deficiency states [48,49] and often involve both the central and peripheral nervous systems alone or in combination [50]. In the peripheral neuromuscular system, the involvement may be localized to motor or sensory nerve cell bodies (neuronopathies), somatic or autonomic pe- ripheral nerves, neuromuscular transmission or striated muscle (Tables 1, 2) [4, 51,52].…”

Section: Paraneoplastic Polyneuropathymentioning

confidence: 99%

Neurophysiological studies in malignant disease with particular reference to involvement of peripheral nerves

Krarup

Crone

2002

Journal of Neurology

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Neurological and neuromuscular disorders are frequent complications in patients with neoplasms and may involve the neuromuscular system, including motor and sensory nerve cell bodies, axons, myelin, neuromuscular transmission and muscle alone or in combination. Electrophysiological studies are of value in delineating the type, degree and extent of involvement, and may be of assistance in pointing towards the underlying cause: paraneoplastic factors, treatment with chemotherapy or radiation or metastatic infiltration. Though some electrophysiological features may be characteristic of certain syndromes, they rarely can stand alone but require clinical, pathological, radiological, and laboratory studies to obtain a diagnosis. Even in cases where such studies are obtained, a final diagnosis may only be ascertained during follow up, since the neuromuscular disorders frequently occur before the neoplasm is detected.

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Neurological Syndromes Associated With Carcinoma the Carcinomatous Neuromyopathies

Cited by 142 publications

References 13 publications

Unusual presentation of seminoma of the testis

Unusual presentation of seminoma of the testis

Cerebellar cortical degeneration with ovarian carcinoma

Neurophysiological studies in malignant disease with particular reference to involvement of peripheral nerves

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