Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain

Hossain, Muhammad M.; Suzuki, Tadahiko; Sato, Itaru; Takewaki, Tadashi; Suzuki, Koichi; Kobayashi, Haruo

doi:10.1016/j.lfs.2005.01.014

Cited by 46 publications

(18 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings may explain not only differences in clinical signs and symptoms but also the effects on the glutamatergic systems caused by the two type II pyrethroids, cyhalothrin and deltamethrin, that we observed. These results, together with our previous studies (Hossain et al, 2004(Hossain et al, , 2005(Hossain et al, , 2006, suggest that cyhalothrin can not be classified as a typical type II pyrethroid, like deltamethrin.…”

Section: Discussionsupporting

confidence: 64%

“…However, our laboratory studies showed that clinical signs of toxicity occurred in the rats after intraperitoneal (i.p.) injection of 60 mg/kg, but not 10 and 20 mg/kg, allethrin, cyhalothrin, and deltamethrin (Hossain et al, 2004(Hossain et al, , 2005(Hossain et al, , 2006. Therefore, the pyrethroids were used in a range of 10-60 mg/kg for these experiments.…”

Section: Pyrethroid Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus

et al. 2008

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 64%

Section: Pyrethroid Treatmentmentioning

confidence: 99%

Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus

et al. 2008

Self Cite

View full text Add to dashboard Cite

“…The assays for AChE inhibition by two commercially available insecticides were carried out using Mafu and Penetrol in which the active components are dichlorvos (an organophosphate) and deltamethrin (a pyrethroid), respectively. The last one was used as a negative control because it does not have any effect on the AChE activity [17]. The insecticides were first dissolved in DMSO and then diluted in distilled water to a final concentration of 0.001, 0.005, 0.01, 0.1, 1.0, and 10.0 ppm.…”

Section: Methodsmentioning

confidence: 99%

Effect of dichlorvos on the acetylcholinesterase from tambaqui (Colossoma macropomum) brain

Assis

Amaral

Castro

et al. 2007

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Dichlorvos is an acutely toxic organophosphorous pesticide that is known as a classical acetylcholinesterase (AChE; EC 3.1.1.7) inhibitor. Here, the brain AChE from the important Amazonian fish tambaqui (Colossoma macropomum) was assayed in the presence of this insecticide and also of deltamethrin, a classical sodium and potassium channel inhibitor (negative control). Four tissue homogenates were analyzed in triplicate for AChE activity using acetylthiocholine as the substrate and 5,5'-dithiobis(2-nitrobenzoic) acid (DTNB) as the color-developing agent. Each tissue homogenate represented pooled brains from five fish. The inhibitory effect of dichlorvos on AChE activities was determined at concentrations from 0.001 to 10 ppm and compared to controls. This effect followed an exponential decay model (y = 9.420 + 26.192e(-x/5.380); r2 = 0.989), presenting IC50 (the concentration of dichlorvos that is required for 50% of AChE inhibition) of 0.081 ppm (0.368 micromol/L). No effect was observed for the deltamethrin, and the concentration 0.0452 micromol/L of dichlorvos was significantly different from this control. These results suggest that tambaqui brain AChE can be proposed as a biomarker for dichlorvos and can be used as a tool for aquatic environment monitoring.

show abstract

“…However, a limited number of studies have attempted to examine potential roles of VGCC in pyrethroid effects using intact mammalian neuronal systems and in all cases failed to demonstrate a significant primary role for VGCC in pyrethroid effects (Meyer and Shafer, 2006;Meyer et al, 2008). Increased neurotransmitter release has been demonstrated after pyrethroid exposure in vivo (Hossain et al, 2004(Hossain et al, , 2005(Hossain et al, , 2008Mubarak Hossain, 2006). However, it is unclear whether this is caused by direct effects of these compounds on presynaptic VGCCs, or whether it is secondary to depolarization caused by pyrethroid actions on VGSCs.…”

Section: Downloaded Frommentioning

confidence: 99%

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

Cao¹,

Shafer

Murray³

2010

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Pyrethroid insecticides bind to voltage-gated sodium channels (VGSCs) and modify their gating kinetics, thereby disrupting neuronal function. Pyrethroids have also been reported to alter the function of other channel types, including activation of voltage-gated calcium channels. Therefore, the present study compared the ability of 11 structurally diverse pyrethroids to evoke Ca 2ϩ influx in primary cultures of mouse neocortical neurons. Nine pyrethroids (tefluthrin, deltamethrin, -cyhalothrin, ␤-cyfluthrin, esfenvalerate, S-bioallethrin, fenpropathrin, cypermethrin, and bifenthrin) produced concentration-dependent elevations in intracellular calcium concentration (

show abstract

Neuromechanical effects of pyrethroids, allethrin, cyhalothrin and deltamethrin on the cholinergic processes in rat brain

Cited by 46 publications

References 38 publications

Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus

Differential presynaptic actions of pyrethroid insecticides on glutamatergic and GABAergic neurons in the hippocampus

Effect of dichlorvos on the acetylcholinesterase from tambaqui (Colossoma macropomum) brain

Mechanisms of Pyrethroid Insecticide-Induced Stimulation of Calcium Influx in Neocortical Neurons

Contact Info

Product

Resources

About