Neurometabolite correlates with personality and stress in healthy emerging adults: A focus on sex differences

Tuovinen, Noora; Yalcin-Siedentopf, Nursen; Welte, Anna-Sophia; Siedentopf, Christian; Steiger, Ruth; Gizewski, Elke R.; Hofer, Alex

doi:10.1016/j.neuroimage.2021.118847

Cited by 3 publications

(3 citation statements)

References 60 publications

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“…The v23ab is the inferior part of Brodmann's area 23 in PCC and would be active during working memory, episodic memory, and primary emotion tasks. As a major hub of the default mode network, the PCC is involved in resolving emotional conflicts and higher order cognitive states [57], including the reward system and information integration functions [58]. The abnormal function of PCC severely impacts the capacity to integrate bottom-up information and causes a deviation of information understanding [59] and subjective anxious arousal [60].…”

Section: Discussionmentioning

confidence: 99%

Alterations of Spontaneous Cortical and Subcortical Activity in Type 2 Diabetes Mellitus with and without Depression

Tian

Liu

et al. 2023

Neuroendocrinology

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Introduction: Type 2 diabetes mellitus (T2DM) patients with depression have a higher risk of complications and mortality than T2DM without depression. However, the exact neuropathophysiological mechanism remains unclear. Consequently, the current study aimed to investigate the alteration of cortical and subcortical spontaneous neural activity in T2DM patients with and without depression. Methods: The demographic data, clinical variables, neuropsychological tests, and functional and anatomical magnetic resonance imaging of depressed T2DM (n=47) of non-depressed T2DM (n=59) and healthy controls (n=41) were collected and evaluated. The correlation analysis, stepwise multiple linear regression, and receiver operating characteristic curve were performed for further analysis. Results: Abnormal neural activities in the bilateral posterior cingulate cortex (PCC) and hippocampus were observed in depressed and non-depressed T2DM and the right putamen of the depressed T2DM. Interestingly, the subcortical degree centrality (DC) of the right hippocampus and putamen were higher in depressed than non-depressed T2DM. Furthermore, the cortical amplitude of low-frequency fluctuation (ALFF) in PCC, subcortical DC in the putamen of depressed T2DM, and hippocampus of non-depressed T2DM was correlated with cognitive scores. In contrast, the cortical fractional ALFF in PCC of non-depressed T2DM was correlated with depression scores. Conclusions: The abnormalities of spontaneous cortical activity in PCC and subcortical activity in the hippocampus might represent the neurobiological feature of cerebral dysfunction in T2DM. Notably, the altered subcortical activity in the right putamen might mainly associate with negative emotion in T2DM, which could be a promising biomarker for recognizing early cerebral dysfunction in depressed T2DM.

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Section: Discussionmentioning

confidence: 99%

Alterations of Spontaneous Cortical and Subcortical Activity in Type 2 Diabetes Mellitus with and without Depression

Tian

Liu

et al. 2023

Neuroendocrinology

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“…What is perceived as a threat or stressor can be highly diverse at an individual level, influenced by extrinsic environmental (social, cultural, economic) and intrinsic (chromosomal, gonadal) determinants, together with the epigenetic transduction of life history and experience. Evidence has shown that females have a generally greater perception of stress [and also pain (69)], which may influence disease processes (70)(71)(72)(73). Interestingly, while perceived stress and coping have been linked to stressinflammatory function, there is also evidence of an inverse relationship in Japanese men (74,75).…”

Section: Stress Perception and Hyperarousalmentioning

confidence: 99%

The sex-dependent response to psychosocial stress and ischaemic heart disease

Helman

Headrick

Stapelberg

et al. 2023

Front. Cardiovasc. Med.

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Stress is an important risk factor for modern chronic diseases, with distinct influences in males and females. The sex specificity of the mammalian stress response contributes to the sex-dependent development and impacts of coronary artery disease (CAD). Compared to men, women appear to have greater susceptibility to chronic forms of psychosocial stress, extending beyond an increased incidence of mood disorders to include a 2- to 4-fold higher risk of stress-dependent myocardial infarction in women, and up to 10-fold higher risk of Takotsubo syndrome—a stress-dependent coronary-myocardial disorder most prevalent in post-menopausal women. Sex differences arise at all levels of the stress response: from initial perception of stress to behavioural, cognitive, and affective responses and longer-term disease outcomes. These fundamental differences involve interactions between chromosomal and gonadal determinants, (mal)adaptive epigenetic modulation across the lifespan (particularly in early life), and the extrinsic influences of socio-cultural, economic, and environmental factors. Pre-clinical investigations of biological mechanisms support distinct early life programming and a heightened corticolimbic-noradrenaline-neuroinflammatory reactivity in females vs. males, among implicated determinants of the chronic stress response. Unravelling the intrinsic molecular, cellular and systems biological basis of these differences, and their interactions with external lifestyle/socio-cultural determinants, can guide preventative and therapeutic strategies to better target coronary heart disease in a tailored sex-specific manner.

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“…For example, loss of white matter tracts connecting the rACC with the amygdala diminishes the ACC’s ability to inhibit amygdala activation, leading to increased fear responses seen in PTSD ( O’Doherty et al, 2018 ). The dorsal ACC (dACC), also labeled the midcingulate cortex (MCC; Stevens et al, 2011 ), is connected to the dlPFC, supplementary motor area (SMA), supramarginal gyrus, and insula revealing its involvement in social cognitive and motor processes ( Overbeek et al, 2021 ; Tuovinen et al, 2022 ). The MCC was found to mediate decision making, executive control ( Mattavelli et al, 2022 ), and emotion regulation ( Li et al, 2014 ) with increased activation in the anterior MCC being associated with decreased negative emotion ( Stevens et al, 2011 ).…”

Section: Structure and Function Of Neural Regions That May Be Connect...mentioning

confidence: 99%

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions

et al. 2022

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Decreased tolerance in response to specific every-day sounds (misophonia) is a serious, debilitating disorder that is gaining rapid recognition within the mental health community. Emerging research findings suggest that misophonia may have a unique neural signature. Specifically, when examining responses to misophonic trigger sounds, differences emerge at a physiological and neural level from potentially overlapping psychopathologies. While these findings are preliminary and in need of replication, they support the hypothesis that misophonia is a unique disorder. In this theoretical paper, we begin by reviewing the candidate networks that may be at play in this complex disorder (e.g., regulatory, sensory, and auditory). We then summarize current neuroimaging findings in misophonia and present areas of overlap and divergence from other mental health disorders that are hypothesized to co-occur with misophonia (e.g., obsessive compulsive disorder). Future studies needed to further our understanding of the neuroscience of misophonia will also be discussed. Next, we introduce the potential of neurostimulation as a tool to treat neural dysfunction in misophonia. We describe how neurostimulation research has led to novel interventions in psychiatric disorders, targeting regions that may also be relevant to misophonia. The paper is concluded by presenting several options for how neurostimulation interventions for misophonia could be crafted.

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Neurometabolite correlates with personality and stress in healthy emerging adults: A focus on sex differences

Cited by 3 publications

References 60 publications

Alterations of Spontaneous Cortical and Subcortical Activity in Type 2 Diabetes Mellitus with and without Depression

Alterations of Spontaneous Cortical and Subcortical Activity in Type 2 Diabetes Mellitus with and without Depression

The sex-dependent response to psychosocial stress and ischaemic heart disease

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions

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