Neuromodulation and Cognitive Control of Emotion

Amidfar, Meysam; Ko, Young Hwii; Kim, Yong Ku

doi:10.1007/978-981-32-9721-0_27

Cited by 24 publications

(11 citation statements)

References 127 publications

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“…While we note that method variation may attribute to the modest correlation of extracted parameters with self-reported distress, a critical point is that task behaviour may reflect psychopathological variance that is not captured by self-report. Importantly, many emerging therapies for psychiatric disorders directly target aberrant decisional processing (Amidfar et al, 2019; Basu et al, 2023; Fisher et al, 2010; Haber et al, 2020; Subramaniam et al, 2014). Behavioural metrics that can repeatably quantify complex cognitive constructs are thus necessary to develop these technologies further.…”

Section: Discussionmentioning

confidence: 99%

Psychometric validation and clinical correlates of an experiential foraging task

McInnes,

Sullivan,

MacDonald

et al. 2023

Preprint

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Measuring the function of decision-making systems is a central goal of computational psychiatry. Individual measures of decisional function could be used to describe neurocognitive profiles that underpin psychopathology and offer insights into deficits that are shared across traditional diagnostic classes. However, there are few demonstrably reliable and mechanistically relevant metrics of decision making that can accurately capture the complex overlapping domains of cognition whilst also quantifying the heterogeneity of function between individuals. The WebSurf task is a reverse-translational human experiential foraging paradigm which indexes naturalistic and clinically relevant decision-making. To determine its potential clinical utility, we examined the psychometric properties and clinical correlates of behavioural parameters extracted from WebSurf in an initial exploratory experiment and a pre-registered validation experiment. Behaviour was stable over repeated administrations of the task, as were individual differences. The ability to measure decision making consistently supports the potential utility of the task in predicting an individual’s propensity for response to psychiatric treatment, in evaluating clinical change during treatment, and in defining neurocognitive profiles that relate to psychopathology. Specific aspects of WebSurf behaviour also correlate with anhedonic and externalising symptoms. Importantly, these behavioural parameters may measure dimensions of psychological variance that are not captured by traditional rating scales. WebSurf and related paradigms might therefore be useful platforms for computational approaches to precision psychiatry.

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Section: Discussionmentioning

confidence: 99%

Psychometric validation and clinical correlates of an experiential foraging task

McInnes,

Sullivan,

MacDonald

et al. 2023

Preprint

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“…The left middle frontal gyrus and the right superior frontal gyrus are key brain regions of the dorsolateral prefrontal cortex (DLPFC) and an important component of the CCN (48,49). Several studies have shown that treatment with repetitive transcranial magnetic stimulation and transcranial direct current stimulation in the CCN, especially DLPFC, can directly improve core symptoms such as mood and cognition in MDD patients (50). Previous studies also found that the TRD group had significantly increased ALFF in the left DLPFC compared to the nTRD group, which is consistent with the results of the present study (30).…”

Section: Discussionmentioning

confidence: 99%

Altered Brain Function in Treatment-Resistant and Non-treatment-resistant Depression Patients: A Resting-State Functional Magnetic Resonance Imaging Study

Sun

Chen

et al. 2022

Front. Psychiatry

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ObjectiveIn this study, we used amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) to observe differences in local brain functional activity and its characteristics in patients with treatment-resistant depression (TRD) and non-treatment-resistant depression (nTRD), and to explore the correlation between areas of abnormal brain functional activity and clinical symptoms.MethodThirty-seven patients with TRD, 36 patients with nTRD, and 35 healthy controls (HCs) were included in resting-state fMRI scans. ALFF and ReHo were used for image analysis and further correlation between abnormal brain regions and clinical symptoms were analyzed.ResultsANOVA revealed that the significantly different brain regions of ALFF and ReHo among the three groups were mainly concentrated in the frontal and temporal lobes. Compared with the nTRD group, the TRD group had decreased ALFF in the left/right inferior frontal triangular gyrus, left middle temporal gyrus, left cuneus and bilateral posterior lobes of the cerebellum, and increased ALFF in the left middle frontal gyrus and right superior temporal gyrus, and the TRD group had decreased ReHo in the left/right inferior frontal triangular gyrus, left middle temporal gyrus, and increased ReHo in the right superior frontal gyrus. Compared with the HC group, the TRD group had decreased ALFF/ReHo in both the right inferior frontal triangular gyrus and the left middle temporal gyrus. Pearson correlation analysis showed that both ALFF and ReHo values in these abnormal brain regions were positively correlated with HAMD-17 scores (P < 0.05).ConclusionAlthough the clinical symptoms were similar in the TRD and nTRD groups, abnormal neurological functional activity were present in some of the same brain regions. Compared with the nTRD group, ALFF and ReHo showed a wider range of brain area alterations and more complex neuropathological mechanisms in the TRD group, especially in the inferior frontal triangular gyrus of the frontal lobe and the middle temporal gyrus of the temporal lobe.

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“…We found that the male TRD group had lower ALFF in the left middle frontal gyrus compared with the female TRD group. The left middle frontal gyrus is part of the dorsolateral prefrontal lobe (DLPFC), and an important component of the CCN [ 26 , 27 , 28 ]. The DLPFC is responsible for top-down regulation of emotional processing, decision making, working memory, and attention processing, and is closely related to the onset of MDD [ 29 , 30 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study

Sun

Luo

et al. 2022

Brain Sciences

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The presence of different clinical symptoms in patients with treatment-resistant depression (TRD) of different sexes may be related to different neuropathological mechanisms. A total of 16 male patients with TRD, 18 female patients with TRD, 18 male healthy controls (HCs) and 19 female HCs completed this study. We used the amplitude of low frequency fluctuations (ALFF) method to analyze the results. Moreover, the correlation between abnormal brain areas and clinical symptoms in different sexes of the TRD groups was also analyzed. The effects of the sex-by-group interaction difference in ALFF among the four groups was located in the left middle frontal gyrus, left precentral gyrus and left precuneus. Post hoc comparisons revealed that the male TRD group had lower ALFF in the left middle frontal gyrus and left precentral gyrus compared with the female TRD group. There was a positive correlation between the left middle frontal gyrus, the left precuneus and the 17-item Hamilton Rating Scale for Depression scale (HAMD-17) scores, and a negative correlation between the left precentral gyrus and the HAMD-17 scores in the female TRD group. This study will provide some clinical reference value for the sex differences in neuropathological mechanisms of TRD.

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Neuromodulation and Cognitive Control of Emotion

Cited by 24 publications

References 127 publications

Psychometric validation and clinical correlates of an experiential foraging task

Psychometric validation and clinical correlates of an experiential foraging task

Altered Brain Function in Treatment-Resistant and Non-treatment-resistant Depression Patients: A Resting-State Functional Magnetic Resonance Imaging Study

Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study

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