Neuromuscular Blocking Action of Alkaloids from a Japanese Crude Drug “Shin-I” (Flos Magnoliae) in Frog Skeletal Muscle

Kimura, Ikuko; Kimura, Masayasu; Yoshizaki, Masao; Yanada, Kazuo; Kadota, Shigetoshi; Kikuchi, Tohru

doi:10.1055/s-2007-969876

Cited by 20 publications

(4 citation statements)

References 5 publications

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“…It has long been used for treatment of headaches and nasal diseases, as a tranquilizer and analgesic, and is considered to be especially efficacious for empyem, chronic inflammation of paranasal sinuses. It has been pharmacologically found to act as an inhibitor on the central nervous system (1,2), to effect neuro-muscular blocking (3,4), and to possess anti-allergic effects (5).…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Kimura

Suzuki²,

Yamada³

et al. 1985

Planta Med

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The anti-inflammatory effects of the major components of the dried flower buds of MAGNOLIA SALICIFOLIA were determined using the pouch granuloma method in mice. Though alkaloids, fatty acids, essential oils, and lignans had no anti-inflammatory effects, neolignans (magnoshinin and magnosalin) significantly inhibited the granuloma tissue formation. The inhibitory effect of magnoshinin was particularly strong, being nearly half of that of hydrocortisone acetate when administered orally. Some differences were noted in the mode of action between the neolignans and the steroidal drugs as the neolignans selectively inhibited the granuloma tissue formation but did not affect the exudation of pouch fluid. The structural specificity of neolignans was also found on their anti-inflammatory effect.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Kimura

Suzuki²,

Yamada³

et al. 1985

Planta Med

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“…A total alkaloidal extract from the aerial parts of L. cubeba showed antimicrobial activity against Staphylococcus aureus. Further purification of this extract led to the isolation of the new compounds 1 and 2, together with the 11 known analogues lirioferine (3) [10], isoboldine (4) [11], boldine (5) [12], norlirioferine (6) [13], laurelliptine (7) [14], wilsonirine (8) [10], N-(methoxycarbonyl)-N-norisoboldine (9) [15], isocorydine (10) [12], muricinine (11) [16], reticuline (12) [10], and N-methylcoclaurine (13) [17]. The structural elucidations of all compounds were based on spectroscopic evidence and comparison with data reported in the literature.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobially Active Isoquinoline Alkaloids fromLitsea cubeba

Feng

Xu²,

Cai³

et al. 2008

Planta Med

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Bioassay-guided fractionation of the alkaloidal extract of the aerial part of Litsea cubeba led to the isolation of two new isoquinoline alkaloids, (+)- N-(methoxycarbonyl)-N-norboldine (1) and (+)-isoboldine beta-N-oxide (2), together with 11 known analogues (3-13). Their structures were established by extensive spectroscopic techniques and by comparing spectroscopic data with those in the literature. Compounds 1 and 4 showed antimicrobial activities. This is the first report on the presence of compounds 1, 2, 6, 8, 9, 11, and 12 in this plant and on the antimicrobial activities of 1 and 4. The bioactivities of isoquinoline alkaloids are also at least partly responsible for the pharmacological function of the folk medicinal plant Litsea cubeba.

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“…Several active constituents exhibiting various biological activities from Magnolia Flower have been identified, according to the literature, including lignans with IL-2 inhibitory 19) and cholesterol-lowering 20) activity, neolignans with antiinflammatory 21) and anti-vasculogenesis 22) activity, and volatile oils with anti-inflammatory activity. 23) There have also been many reports on the isolation of volatile oils, 24) lignans, 25) neolignans, 25) phenylpropanoids, 26) alkaloids, 27) monoterpene glycosides, 28) and flavonoids 15) from Magnolia species in efforts to study biological activity.…”

Section: Introductionmentioning

confidence: 99%

Structures and Inhibitory Activities for Interleukin-2 Production of Seasonally Variable Constituents in Flower Parts of <i>Magnolia kobus</i> at Different Growth Stages

Oshima

Kume

Umeda

et al. 2020

CHEMICAL & PHARMACEUTICAL BULLETIN

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Magnolia Flower is a crude drug used for the treatment of headaches, toothaches, and nasal congestion. Here, we focused on Magnolia kobus, one of the botanical origins of Magnolia Flower, and collected the flower parts at different growth stages to compare chemical compositions and investigate potential inhibitory activities against interleukin-2 (IL-2) production in murine splenic T cells. After determining the structures, we examined the inhibitory effects of the constituents of the bud, the medicinal part of the crude drug, against IL-2 production. We first extracted the flower parts of M. kobus from the bud to fallen bloom stages and analysed the chemical compositions to identify the constituents characteristic to the buds. We found that the inhibitory activity of the buds against IL-2 production was more potent than that of the blooms. We isolated two known compounds, tiliroside (1) and syringin (2), characteristic to the buds from the methanol (MeOH) extract of Magnolia Flower. Moreover, we examined the inhibitory activities of both compounds against IL-2 production and found that tiliroside (1) but not syringin (2), showed strong inhibitory activity against IL-2 production and inhibited its mRNA expression. Thus, our strategy to examine the relationship between chemical compositions and biological activities during plant maturation could not only contribute to the scientific evaluation of medicinal parts of crude drugs but also assist in identifying biologically active constituents that have not yet been reported.

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Neuromuscular Blocking Action of Alkaloids from a Japanese Crude Drug “Shin-I” (Flos Magnoliae) in Frog Skeletal Muscle

Cited by 20 publications

References 5 publications

Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Antimicrobially Active Isoquinoline Alkaloids fromLitsea cubeba

Structures and Inhibitory Activities for Interleukin-2 Production of Seasonally Variable Constituents in Flower Parts of <i>Magnolia kobus</i> at Different Growth Stages

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