Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Kimura, Masayasu; Suzuki, Jun; Yamada, Tadashi; Yoshizaki, Masao; Kikuchi, Tohru; Kadota, Shigetoshi; Matsuda, Satako

doi:10.1055/s-2007-969493

Cited by 46 publications

(24 citation statements)

References 5 publications

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“…Moreover, it has been reported that Flos magnoliae extract (FME) has an antiangiogenic (23) and an anti-inflammatory effect (24). In this study, we demonstrated that FME inhibited the development of type 1 diabetes, indicating that FME has the potential for use as a therapeutic agent to treat diabetes.…”

Section: Introductionmentioning

confidence: 54%

Beneficial effect of Flos magnoliae extract on multiple low dose streptozotocin-induced type 1 diabetes development and cytokine-induced β-cell damage

Kim

Song²,

Kim³

et al. 1998

Int J Mol Med

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Abstract. In the present study, Flos magnoliae extract (FME) was evaluated to determine if it could protect pancreatic ß-cells against multiple low dose streptozotocin (MLDS) and interleukin-1ß and interferon-γ. Injection of mice with MLDS resulted in hyperglycemia and hypoinsulinemia, which was confirmed by immunohistochemical staining. However, the induction of diabetes by MLDS was completely prevented when mice were pretreated with FME. FME also effectively protected ß-cells against cytokine toxicity, which was demonstrated by an increase in the viability of rat insulinoma RINm5F cells and by preserved insulin secreting responses to glucose in isolated rat islets. Moreover, cytokine-induced nitric oxide production and iNOS mRNA and protein expression were significantly reduced in RINm5F cells and islets that were preincubated with FME. The molecular mechanism by which FME inhibits iNOS gene expression in in vitro and in vivo appears to involve inhibition of NF-κB activation. Taken together, these results reveal the possible therapeutic value of FME for the prevention of type 1 diabetes progression.

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Section: Introductionmentioning

confidence: 54%

Beneficial effect of Flos magnoliae extract on multiple low dose streptozotocin-induced type 1 diabetes development and cytokine-induced β-cell damage

Kim

Song²,

Kim³

et al. 1998

Int J Mol Med

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“…The drug was collected between late winter and early spring before flowering, removed from branchlet, and dried in the shade. Pharmacological studies have revealed in to have neuromuscular bloking, 2 inotropic effect, 3 anti-inflammatory, [4][5][6][7] anti-allergy, 8 anti-angiogenic, 9 PAF receptor antagolist 10 and vasorelaxant activities. 11 HPLC-UV analytical methods for biondnoid I, 12 magnolin, 13 magnolin and fargesin, 14 and magnolin and anthricin 15 had been reported.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and Pattern Recognition Analyses for the Quality Evaluation of Magnoliae Flos by HPLC

Fang¹,

Shen²,

Moon³

et al. 2010

Bulletin of the Korean Chemical Society

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In this study, quantitative and pattern recognition analysis for the quality evaluation of Magnoliae Flos using HPLC/ UV was developed. For quantitative analysis, eleven major bioactive lignan compounds were determined. The separation conditions employed for HPLC/UV were optimized using ODS C18 column (250 × 4.6 mm, 5 µm) with isocratic elution of acetonitrile and water with 1% acetic acid as the mobile phase at a flow rate of 1.0 mL/min and a detection wavelength of 278 nm. These methods were fully validated with respect to the linearity, accuracy, precision, recovery, and robustness. The HPLC/UV method was applied successfully to the quantification of eleven major compounds in the extract of Magnoliae Flos. The HPLC analytical method for pattern recognition analysis was validated by repeated analysis of twenty one reference samples corresponding to seven different species of Magnoliae Flos and nine samples purchased from market. The results indicate that the established HPLC/UV method is suitable for the quantitative analysis and quality control of multi-components in Magnoliae Flos.

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“…Magno salin and magnoshinin are isolated from 'Shin-i' [1] and are classed as neolignans. We have previously re ported that both compounds (per os) inhibit the for mation of granuloma in the mouse pouch induced by Freund's complete adjuvant (FCA) containing croton oil [2]. The inhibitory effect of magnoshinin is greater than that of magnosalin, and the potency is half that of hydrocortisone, a typical anti-inflammatory ste roid.…”

Section: Introductionmentioning

confidence: 99%

Selective Inhibition by Magnosalin and Magnoshinin, Compounds from ‘Shin-i’ (Flos magnoliae), of Adjuvant-Induced Angiogenesis and Granuloma Formation in the Mouse Pouch

Kimura

Kobayashi²,

Luo³

et al. 1990

Int Arch Allergy Immunol

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Inhibitory effects of magnosalin and magnoshinin, compounds from the crude drug ‘Shin-I’ (Flos magnoliae), on angiogenesis and pouch granuloma formation induced by an adjuvant containing croton oil were investigated. Magnosalin inhibited angiogenesis 2.4-fold (intra-pouch) and 9.7-fold (intraperitoneal) more strongly than granuloma formation. The inhibition of angiogenesis by magnosalin was 5-fold (intra-pouch) and 21-fold (intraperitoneal) weaker than that by hydrocortisone. In contrast, intraperitoneal magnoshinin inhibited granuloma formation 2.5-fold more strongly than angiogenesis. The regression coefficients of anti-angiogenesis vs. the inhibition of granuloma formation were 1.79 for magnosalin, 1.11 for hydrocortisone, and 0.61 for magnoshinin. These results show that the anti-chronic inflammatory effect of ‘Shin-i’ was caused by selective inhibition of angiogenesis by magnosalin and of granuloma formation by magnoshinin.

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Anti-Inflammatory Effect of Neolignans Newly Isolated from the Crude Drug “Shin-i” (Flos Magnoliae)

Cited by 46 publications

References 5 publications

Beneficial effect of Flos magnoliae extract on multiple low dose streptozotocin-induced type 1 diabetes development and cytokine-induced β-cell damage

Beneficial effect of Flos magnoliae extract on multiple low dose streptozotocin-induced type 1 diabetes development and cytokine-induced β-cell damage

Quantitative and Pattern Recognition Analyses for the Quality Evaluation of Magnoliae Flos by HPLC

Selective Inhibition by Magnosalin and Magnoshinin, Compounds from ‘Shin-i’ (Flos magnoliae), of Adjuvant-Induced Angiogenesis and Granuloma Formation in the Mouse Pouch

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