Selective Inhibition by Magnosalin and Magnoshinin, Compounds from ‘Shin-i’ (Flos magnoliae), of Adjuvant-Induced Angiogenesis and Granuloma Formation in the Mouse Pouch

Kimura, Masayasu; Kobayashi, Shogo; Luo, Bao; Kimura, Ikuko

doi:10.1159/000235267

Cited by 16 publications

(2 citation statements)

References 6 publications

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“…Of these lignans and neolignans, which are considered to be important bioactive ingredients, magnoshinin (35) and magnosalin (36) have been extensively studied. These two compounds have been reported to significantly inhibit croton oil-induced pouch granuloma formation and pouch exudation [36,74]. Kimura et al [74] suggested that inhibition of adjuvant-induced angiogenesis and granuloma formation by magnosalin (36) may be involved in the anti-inflammatory effects of FM.…”

Section: Bioactivities Of Components Of Flos Magnoliaementioning

confidence: 99%

“…These two compounds have been reported to significantly inhibit croton oil-induced pouch granuloma formation and pouch exudation [36,74]. Kimura et al [74] suggested that inhibition of adjuvant-induced angiogenesis and granuloma formation by magnosalin (36) may be involved in the anti-inflammatory effects of FM. Magnosalin (36) and magnoshinin (35) have also been demonstrated to induce fetal bovine serum-stimulated and interleukin (IL-1 )-stimulated tube formations, which resulted in inhibition of endothelial cell proliferation [42,75].…”

Section: Bioactivities Of Components Of Flos Magnoliaementioning

confidence: 99%

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Chemistry and Bioactivity of Flos Magnoliae, A Chinese Herb for Rhinitis and Sinusitis

Shen

Zhou³

et al. 2008

CMC

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Flos Magnoliae (FM, Chinese name: Xin-yi) is one of the most commonly used Chinese medicinal herbs. It has a long history of clinical use for managing rhinitis, sinusitis and headache. More than 20 different FM species have been used clinically, which makes species identification and evaluation of pharmacological effects of individual chemical ingredients difficult. In this review, we have summarized the current knowledge on FM phytochemistry and its bioactivity activities. The bioactive compounds in FM include both lipid and water-soluble components. More than 90% of the essential components of FM species are terpenoids, including monoterpenes and sesquiterpenes. Lignans and neolignans including tetrahydrofurofuran, tetrahydrofuran and aryltetralin are also present in FM species. A small number of water-soluble compounds have been isolated from Magnolia flower buds, including a benzylisoquinoline alkaloid magnoflorine, an ester ethyl-E-p-hydroxyl-cinnamate and a flavonoid biondnoid. A wide range of pharmacological actions of FM have been reported, including anti-allergy, anti-inflammation and anti-microbial activity. The structure-activity relationship analysis revealed the influence of methylation at position 5 on the 3,7-dioxabicyclo-(3,3,0)-octane backbone of six lignans in antagonistic activities against platelet-activating factor. In addition, the trans stereoisomer fargesin had a much lower bioactivity than the cis stereoisomer demethoxyaschantin. Recent studies have been directed towards the isolation of other bioactive compounds. Further studies on FM may help to develop new anti-inflammatory and anti-allergic drugs.

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Section: Bioactivities Of Components Of Flos Magnoliaementioning

confidence: 99%

Section: Bioactivities Of Components Of Flos Magnoliaementioning

confidence: 99%

Chemistry and Bioactivity of Flos Magnoliae, A Chinese Herb for Rhinitis and Sinusitis

Shen

Zhou³

et al. 2008

CMC

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Inducible nitric oxide synthase inhibitors: A comprehensive update

Minhas

Bansal

2019

Medicinal Research Reviews

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Inducible nitric oxide synthase (iNOS), which is expressed in response to bacterial/proinflammatory stimuli, generates nitric oxide (NO) that provides cytoprotection. Overexpression of iNOS increases the levels of NO, and this increased NO level is implicated in pathophysiology of complex multifactorial diseases like Parkinson's disease, Alzheimer's disease, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Selective inhibition of iNOS is an effective approach in treatment of such complex diseases. L-Arginine, being a substrate for iNOS, is the natural lead to develop iNOS inhibitors. More than 200 research reports on development of nitric oxide synthase inhibitors by different research groups across the globe have appeared in literature so far. The first review on iNOS, in 2002, discussed the iNOS inhibitors under two classes that is, amino acid and non-amino acid derivatives. Other review articles discussing specific chemical classes of iNOS inhibitors also appeared during last decade. In the present review, all reports on both natural and synthetic iNOS inhibitors, published 2002 onwards, are studied, classified, and discussed to provide comprehensive information on iNOS inhibitors. The synthetic inhibitors are broadly classified into two categories that is, arginine and non-arginine analogs. The latter are further classified into amidines, five-or six-membered heterocyclics, fused cyclics, steroidal type, and chalcones analogs. Structures of the most/significantly potent compounds from each report are provided to know the functional groups important for incurring iNOS inhibitory activity and selectivity. This review is aimed to provide a comprehensive view to the medicinal chemists for rational designing of novel and potent iNOS inhibitors. K E Y W O R D S arginine, inflammation, inhibitors, multifactorial disease, nitric oxide 1 | INTRODUCTION Nitric oxide (NO) is a relaxing factor derived from endothelium, which is responsible for neuronal transmission, cardiovascular, gastrointestinal, genitourinary, respiratory, antipathogenic, and antitumor responses. The production of NO is effected by nitric oxide synthase (NOS) through catalysis of NADPH-dependent oxidation of L-arginine (the substrate). 1NOS exists in three distinct isoforms, depending on the site of its existence that is, neuronal NOS (nNOS, type I), inducible or inflammatory NOS (iNOS, type II) and endothelial NOS (eNOS, type III). Constitutive NOS are regulated by the binding of calcium-calmodulin protein, whereas iNOS is transcriptionally regulated and calcium-calmodulin independent. NO plays both physiological and pathological roles depending on the magnitude and duration of its production. 2 The physiological roles of NO are executed by soluble guanylate cyclase. Indeed, NO activates it, with the consequent increase of cyclic guanosine-3′,5′-monophosphate (cGMP) level, which subsequently activates intracellular effector molecules, cGMPdependent protein kinases, cGMP-gated ion channels, and cGMP-regulated phosphodiesteras...

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Interferon-γ-activated macrophages enhance angiogenesis from endothelial cells of rat aorta

et al. 1994

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Selective Inhibition by Magnosalin and Magnoshinin, Compounds from ‘Shin-i’ (Flos magnoliae), of Adjuvant-Induced Angiogenesis and Granuloma Formation in the Mouse Pouch

Cited by 16 publications

References 6 publications

Chemistry and Bioactivity of Flos Magnoliae, A Chinese Herb for Rhinitis and Sinusitis

Chemistry and Bioactivity of Flos Magnoliae, A Chinese Herb for Rhinitis and Sinusitis

Inducible nitric oxide synthase inhibitors: A comprehensive update

Interferon-γ-activated macrophages enhance angiogenesis from endothelial cells of rat aorta

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