Neuromuscular Blocking Properties of Various Polypeptide Antibiotics.

Adamson, R. H.; Marshall, F. N.; Long, J. P.

doi:10.3181/00379727-105-26154

Cited by 37 publications

(10 citation statements)

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“…The greater effectiveness of calcium as an antagonist when compared to neostigmine is similar to the situation reported for aminoglycoside antibiotics on the mouse diaphragm (Singh et al, 1978a;Singh, Marshall & Harvey, 1978b) and other preparations (Adamson, Marshall & Long, 1960;Adams er al., 1976;Wright & Collier, 1977). Calcium has been found to be an effective antagonist of prejunctional block produced by magnesium, whereas neostigmine is less effective.…”

Section: Discussionsupporting

confidence: 70%

The neuromuscular blocking action of spectinomycin on the mouse hemidiaphragm preparation

Singh

Marshall

Harvey

1979

Clin Exp Pharmacol Physiol

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1. The mechanism of action of the muscle paralysing property of the antibiotic spectinomycin has been investigated on the isolated mouse phrenic nerve-hemidiaphragm preparation. 2. Spectinomycin produced a neuromuscular blockade that was poorly reversed by neostigmine (3 mumol/l) but well reversed by both calcium (5 mmol/l) and 3,4-diaminopyridine (0.1 mmol/l). 3. Intracellular techniques were used to record endplate potentials and miniature endplate potentials from hemidiaphragms paralysed by spectinomycin. Miniature endplate potentials were reduced both in frequency and in amplitude. The quantal content of the endplate potential during spectinomycin paralysis calculated by the method of variance was 14, a value similar to that found in preparations paralysed by the prejunctionally active magnesium. 4. Thus spectinomycin possesses weak neuromuscular blocking activity by a predominant action on acetylcholine release.

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Section: Discussionsupporting

confidence: 70%

The neuromuscular blocking action of spectinomycin on the mouse hemidiaphragm preparation

Singh

Marshall

Harvey

1979

Clin Exp Pharmacol Physiol

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“…From previous experiments it is known that neomycin sulfate, strepto mycin and dihydrostreptomycin sulfate, polymyxin A and B sulfate, colis tin sulfate and viomycin sulfate interfere with the neuromuscular trans mission [1,3,13]. This blockade induced by neomycin, streptomycin and viomycin was reversed by neostigmin [1,2,5,10,11,13].…”

Section: Discussionmentioning

confidence: 95%

“…This blockade induced by neomycin, streptomycin and viomycin was reversed by neostigmin [1,2,5,10,11,13]. This effect seems to be presynaptic [4,7,11].…”

Section: Discussionmentioning

confidence: 95%

The Effect of Streptomycin and Colistin on Myasthenic Patients

Herishanu¹

1969

Stereotact Funct Neurosurg

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“…From previous experimental studies it is known that the neuromuscu lar transmission is disturbed after administration of neomycin, streptomy cin, polymyxin B sulfate and colistin sulfate [1,3,14].…”

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confidence: 99%

The Electromyographic Changes Induced by Antibiotics

Herishanu¹,

Taustein²

1971

Stereotact Funct Neurosurg

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Thirthy patients who were not suffering from any neuromuscular disease received therapeutic doses of ampicillin, erythromycin and tetracycline hydrochloride; electromyographic recordings were performed before, during and after the administration of these antibiotics. An electromyographic myasthenic-like picture was obtained during ampicillin and erythromycin administration; this picture normalized after the discontinuation of the antibiotics. A marked facilitation in the size of the muscle action potential during supramaximal repetitive nerve stimulation was observed in control patients from the first 2 groups. This finding points to a presynaptic effect of erythromycin and ampicillin. Tetracycline hydrochloride did not alter the electromyographic recording.

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Neuromuscular Blocking Properties of Various Polypeptide Antibiotics.

Cited by 37 publications

References 0 publications

The neuromuscular blocking action of spectinomycin on the mouse hemidiaphragm preparation

The neuromuscular blocking action of spectinomycin on the mouse hemidiaphragm preparation

The Effect of Streptomycin and Colistin on Myasthenic Patients

The Electromyographic Changes Induced by Antibiotics

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