Neuromuscular complications of coronavirus disease-19

Suh, Joome; Amato, Anthony A.

doi:10.1097/wco.0000000000000970

Cited by 26 publications

(36 citation statements)

References 62 publications

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“…It is unknown whether the COVID‐19‐associated CIM differs from its non‐COVID‐19 counterpart, 8 and whether direct viral infection plays a role in COVID‐19‐associated myopathy. 9 This study examined COVID‐19‐associated CIM with a focus on its pathological changes.…”

mentioning

confidence: 99%

COVID‐19‐Associated Critical Illness Myopathy with Direct Viral Effects

Dodig

Tarnopolsky

Margeta

et al. 2022

Annals of Neurology

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Coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2 infection) can lead to intensive care unit (ICU) admission and critical illness myopathy (CIM). We examined 3 ICU patients with COVID-19 who required mechanical ventilation for pneumonia and developed CIM. Pathological examination of the skeletal muscle biopsies revealed myopathic changes consistent with CIM, variable inflammation with autophagic vacuoles, SARS-CoV immunostaining + fibers/granules, and electron microscopy findings of mitochondrial abnormalities and coronaviruslike particles. Although mitochondrial dysfunction with compromised energy production is a critical pathogenic mechanism of non-COVID-19-associated CIM, in our series of COVID-19-associated CIM, myopathic changes including prominent mitochondrial damage suggest a similar mechanism and association with direct SARS-CoV-2 muscle infection.

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confidence: 99%

COVID‐19‐Associated Critical Illness Myopathy with Direct Viral Effects

Dodig

Tarnopolsky

Margeta

et al. 2022

Annals of Neurology

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“…Since the pandemic, many sequelae of COVID-19, termed as long-COVID-19 or post-acute COVID-19 syndrome, have been reported [6]. Although COVID-19 primarily causes respiratory disease, a wide breadth of neurologic complications has also been reported [2].…”

Section: Discussionmentioning

confidence: 99%

“…This might be suggestive of GBS variant-AMSAN. However, GBS is generally considered a postinfectious or para-infectious inflammatory neuropathy [2]. Moreover, the patient's weakness presented during intensive care.…”

Section: Discussionmentioning

confidence: 99%

Electrodiagnostic Follow-Up of COVID-19-Associated Critical Illness Polyneuropathy: A Case Report

Choi¹,

Kim²,

Lee³

et al. 2021

J Electrodiagn Neuromuscul Dis

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Since the coronavirus disease 2019 (COVID-19) outbreak, many neurologic and neuromuscular sequelae have been reported [1]. Among these, stroke is the most notorious complication due to the thrombo-inflammatory nature of . For cases that involve the peripheral nerves, Guillain-Barré syndrome Neurologic complications have been reported in patients with coronavirus disease 2019 (COVID-19). Here, we report a case of post-COVID-19 critical illness polyneuropathy and describe the longitudinal follow-up. A 73-year-old woman presented with peripheral muscle weakness following COVID-19 pneumonia and mechanical ventilation for 16 days. Despite treatment, her fever persisted, and oxygen supplementation was continued. Blood cultures revealed Candida albicans infection, prompting antibiotic and antifungal therapy with oxygen supplementation. Two months later, the patient responded to treatment and was extubated. However, she exhibited peripheral muscle weakness. Nerve conduction studies showed peripheral polyneuropathy with axonal involvement, consistent with critical illness polyneuropathy. After 2 months of inpatient rehabilitation, the patient's weakness and activity limitations improved. However, nerve conduction studies taken after 4.5 months showed persistent bilateral lower extremity axonal neuropathy. To the authors' best knowledge, this is the first report of longitudinal follow-up with a functional evaluation of COVID-19-associated critical illness polyneuropathy.

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“…The current literature contains many case reports of pediatric patients who presented with various symptoms that note muscle involvement, including myalgia, fatigue, and muscle weakness [ 4 , 19 , 25 , 50 , 62 ]. Furthermore, elevated creatine kinase titers have also been reported, and it is known that ACE2 is also expressed in skeletal muscle, suggesting that SARS-CoV-2 could cause viral myositis or rhabdomyolysis [ 83 – 85 ]. In addition, severe COVID-19 patients could develop critically ill myopathy owing to prolonged hospitalization, multiple-organ failure, mechanical ventilation, and use of corticosteroids or neuromuscular blockers [ 86 , 87 ].…”

Section: Muscle Involvementmentioning

confidence: 99%