“…The objective of this paper is to provide a systematic integration of the various components active in the hypothesis (creep, neuromuscular control, stability, inflammation/ tissue biology) obtained from a long series of experimental research projects in animal models (Williams et al, 2000;Eversull et al, 2001;Solomonow et al, 2003bSolomonow et al, , 2008Solomonow et al, , 2011Claude et al, 2003;Hoops et al, 2007;Le et al, 2007;Lu et al, 2004Lu et al, , 2008Navar et al, 2006;Youssef et al, 2008;Le et al, 2009;Ben-Masaud et al, 2009;King et al, 2009;D'Ambrosia et al, 2010;Pinski et al, 2010) and healthy humans (Solomonow et al, 2003a;Olson et al, 2004Olson et al, , 2006Olson et al, , 2009Li et al, 2007) in order to provide a comprehensive model of the multi-factorial etiology of RLI, offer validating support for the acute phase of the hypothesis and allow the potential developments of science based methods for its treatment and prevention.…”