1974
DOI: 10.7326/0003-4819-80-2-182
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Neuromuscular Disease in Primary Hyperparathyroidism

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Cited by 258 publications
(90 citation statements)
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“…Among these last disturbances, high parathyroid hormone (PTH) levels, frequently observed in CRF patients, may be implicated in the nutritional abnormalities found in these patients. In fact, it has been observed that patients with primary hyperparathyroidism may show evidence of weight loss, weakness and muscle atrophy and negative nitrogen balance (15)(16)(17). It is not clear, however, to what extent these findings may be caused by either a direct deleterious effect of PTH on protein metabolism (18) or an indirect effect causing fatigue, anorexia, neuropsychiatric disturbances, myopathy or bone disease (15,16).…”
Section: Introductionmentioning
confidence: 91%
See 1 more Smart Citation
“…Among these last disturbances, high parathyroid hormone (PTH) levels, frequently observed in CRF patients, may be implicated in the nutritional abnormalities found in these patients. In fact, it has been observed that patients with primary hyperparathyroidism may show evidence of weight loss, weakness and muscle atrophy and negative nitrogen balance (15)(16)(17). It is not clear, however, to what extent these findings may be caused by either a direct deleterious effect of PTH on protein metabolism (18) or an indirect effect causing fatigue, anorexia, neuropsychiatric disturbances, myopathy or bone disease (15,16).…”
Section: Introductionmentioning
confidence: 91%
“…It increases bone turnover (33) and induces neuropathy (34), myopathy (15,16), cardiac hypertrophy (35), hyperlipidemia (36), carbohydrate intolerance (12) and immune dysfunction (37). Although specific studies are lacking, such conditions could influence the nutritional status of uremic patients with secondary hyperparathyroidism.…”
Section: Discussionmentioning
confidence: 99%
“…Serum levels of 1.25(OH) 2 D 3 have been associated with decreased muscle strength, lower endurance [8,9,10,11,12], reduced functional mobility [13,14], and atrophy of fast-twitch muscle fibers [35]. Also, 1.25(OH) 2 D 3 is an effective treatment of the iPTH-related decrease of energy metabolism in skeletal muscle and proteolysis of muscle proteins [36,37,38]. Low 1.25(OH) 2 D 3 serum Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Patten et al 1 had reported 2 cases of hyperplasia and neuromuscular symptoms but the electrophysiological findings were compatible with myopathy (cases 4 and 6) .In 1984, Patten and Pages 2 reported a case resembling motor neuron disease and hyperplasia of the parathyroid. Patten et al 1 described 16 cases with neuromuscular symptoms associated with primary hyperparathyroidism and performed muscle biopsy which suggested neurogenic damage in all of them. However, the electrophysiological studi e s had a different pattern 3 and only 6 patients showed lower and/or upper motor neuron signs (Table 1).…”
Section: Discussionmentioning
confidence: 97%