Neuromuscular Effects of Respiratory and Metabolic Acid-Base Changes In Vitro  With and Without Nondepolarizing Muscle Relaxants

Ono, Kazumi; Nagano, Osamu; Ohta, Yoshihiro; Kosaka, Futami

doi:10.1097/00000542-199010000-00017

Cited by 29 publications

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“…The acid-base change has been found not to alter the nondepolarizing muscle relaxant characteristics of rocuronium. In general, increasing pH by decreasing PCO 2 or by increasing HCO 3 − decreases the potency of monoquaternary relaxants, including rocuronium [30,31]. However, pharmacologic characteristics of rocuronium were not affected when mixed with 8.4% NaHCO 3 (3 mL) immediately before administration in patients.…”

Section: Discussionmentioning

confidence: 98%

Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial

Han

Koo

Choi

et al. 2007

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 98%

Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial

Han

Koo

Choi

et al. 2007

Journal of Clinical Anesthesia

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“…NaHCO 3 supplementation has been shown to increase muscle fiber conduction velocity and reduce force decline in sustained maximal contraction after a 50-min submaximal cycling [22]. An in vitro study also revealed that alkalosis induced by high [HCO3 - ] resulted in an increase in twitch tension in isolated rat phrenic nerve-hemidiaphragm after electrical stimulations [37]. Therefore, it is possible that NaHCO 3 could help to restore certain level of neural functions after the simulated match, resulting in the better skilled performance in the bicarbonate trial.…”

Section: Discussionmentioning

confidence: 99%

Sodium bicarbonate supplementation prevents skilled tennis performance decline after a simulated match

Shih

Yang

et al. 2010

Journal of the International Society of Sports Nutrition

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The supplementation of sodium bicarbonate (NaHCO3) could increase performance or delay fatigue in intermittent high-intensity exercise. Prolonged tennis matches result in fatigue, which impairs skilled performance. The aim of this study was to investigate the effect of NaHCO3 supplementation on skilled tennis performance after a simulated match. Nine male college tennis players were recruited for this randomized cross-over, placebo-controlled, double-blind study. The participants consumed NaHCO3 (0.3 g. kg-1) or NaCl (0.209 g. kg-1) before the trial. An additional supplementation of 0.1 g. kg-1 NaHCO3 or 0.07 g. kg-1 NaCl was ingested after the third game in the simulated match. The Loughborough Tennis Skill Test was performed before and after the simulated match. Post-match [HCO3-] and base excess were significantly higher in the bicarbonate trial than those in the placebo trial. Blood [lactate] was significantly increased in the placebo (pre: 1.22 ± 0.54; post: 2.17 ± 1.46 mM) and bicarbonate (pre: 1.23 ± 0.41; post: 3.21 ± 1.89 mM) trials. The match-induced change in blood [lactate] was significantly higher in the bicarbonate trial. Blood pH remained unchanged in the placebo trial (pre: 7.37 ± 0.32; post: 7.37 ± 0.14) but was significantly increased in the bicarbonate trial (pre: 7.37 ± 0.26; post: 7.45 ± 0.63), indicating a more alkaline environment. The service and forehand ground stroke consistency scores were declined significantly after the simulated match in the placebo trial, while they were maintained in the bicarbonate trial. The match-induced declines in the consistency scores were significantly larger in the placebo trial than those in the bicarbonate trial. This study suggested that NaHCO3 supplementation could prevent the decline in skilled tennis performance after a simulated match.

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“…If buffered diffusion were to account for the differences in onset times of MRs with different affinities, then MRs with different affinities should also display different onset times both in isolated muscle in vitro and in isolated perfused limbs. This is not the case, however (Beaufort et al 1998;De Haes et al 2002;Ono et al 1990;Sato and Ono 1981;Segawa et al 1967).…”

Section: Discussionmentioning

confidence: 98%

Onset–potency relationship of nondepolarizing muscle relaxants: a reexamination using simulations

Bhatt

Amann

Nigrovic

2007

Can. J. Physiol. Pharmacol.

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Nondepolarizing muscle relaxants (MRs) display an inverse onset-potency relationship, that is, less potent MRs display a more rapid onset. We have conducted the current investigation to estimate the impact of variable pharmacokinetic or pharmacodynamic properties of the MRs on potency and onset time, and on the onset-potency relationship. Using a model of neuromuscular transmission, we changed either the affinity of MRs for the postsynaptic receptors or the pharmacokinetic properties of the MRs. The elimination rate constant, k(10), which defines the systemic clearance, was assigned one of 9 values and the transport rate constant, k(12), one of 5 values. The transport rate constant into the effect compartment was constant (k(e1) = 0.2 min(-1)). Only one parameter was altered at a time. With constant pharmacokinetics, a 100-fold decrease in affinity caused a proportional decrease in potency, but little change (0.02 min) in onset time. With constant affinity, increasing the clearance from 1 to 250 mL x kg(-1) x min(-1) shortened the onset time from 7.2 to 0.7 min and decreased the potency 12-fold. In a double logarithmic plot, the onset-potency relationship was linear. Lesser affinities produce a nearly parallel rightward shift of the regression lines. The inverse onset-potency relationship may be explained by the pharmacokinetic factors producing changes in both the potency and onset times.

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Neuromuscular Effects of Respiratory and Metabolic Acid-Base Changes In Vitro With and Without Nondepolarizing Muscle Relaxants

Cited by 29 publications

References 0 publications

Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial

Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial

Sodium bicarbonate supplementation prevents skilled tennis performance decline after a simulated match

Onset–potency relationship of nondepolarizing muscle relaxants: a reexamination using simulations

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