Neuromuscular function after muscle fatigue in Charcot–Marie–Tooth type 1A patients

Menotti, Federica; Bazzucchi, Ilenia; Felici, Francesco; Damiani, Antonello; Gori, María; Macaluso, Andrea

doi:10.1002/mus.23366

Cited by 24 publications

(40 citation statements)

References 32 publications

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“…The degree of fatigue in the muscle itself, which we refer to as peripheral fatigue, may be estimated by using electrical stimulation (maximal twitch, MT) at rest (see Enoka and Duchateau, 2008 for a review). Fatigue has also been studied by measuring neural activation of the peripheral muscle from surface EMG, which reflects the overall number, firing rate, and synchronization of the active motor units (Menotti et al, 2012). Fatigue often begins gradually soon after the beginning of the contractions, even though the individual is able to continue the task (Søgaard et al, 2006; Barry and Enoka, 2007); thus, fatigue, task failure, and exhaustion should be distinguished.…”

Section: Introductionmentioning

confidence: 99%

The neurophysiology of central and peripheral fatigue during sub-maximal lower limb isometric contractions

Berchicci¹,

Menotti²,

Macaluso³

et al. 2013

Front. Hum. Neurosci.

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Fatigue has been defined as an exercise-induced decline in force generation capacity because of changes at both the peripheral and central levels. Movement is preceded and accompanied by brain activities related to the preparation and execution of movement (movement related cortical potentials, MRCP), which have been correlated with the perception of effort (RPE). We combined force measurements, surface electromyography (sEMG), peripheral electrical stimulation (maximal twitch, MT) and MRCP analysis to further our understanding of the neural correlates of peripheral and central changes during a fatiguing task involving the lower limbs. Eighteen healthy volunteers performed 4 blocks of isometric knee extensions at 40% of the maximal voluntary contraction (MVC) for a total of 240 2-s contractions. At the baseline and after each block, we measured RPE, MT and MVC. We simultaneously recorded the force of the knee extensor muscles, root mean square (RMS) of the sEMG of the vastus lateralis muscle, and electroencephalography (EEG) from 64 channels. The MRCPs were extracted from the EEG recordings and averaged in the early (Block 1–2) and late (Block 3–4) blocks. Two cohorts were obtained by cluster analysis based on the RPE (i.e., perception of effort) and MT (i.e., peripheral fatigue). We observed a significant decline in both the MVC (−13%) and RMS (−25%) of the sEMG signal over the course of the task; thus, muscle fatigue had occurred in all of the participants regardless of the cohort. The MRCP amplitude was larger in the fatigued than the non-fatigued MT cohort in the supplementary and premotor areas, whereas the MRCP amplitude was larger in the fatigued than the non-fatigued RPE cohort in the aforementioned areas, and also in the primary motor and prefrontal cortices (PFC). The increase in the positive activity of the PFC, along with the perception of effort, represents a novel result, suggesting that it is modulated more by the perception of effort than peripheral fatigue.

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Section: Introductionmentioning

confidence: 99%

The neurophysiology of central and peripheral fatigue during sub-maximal lower limb isometric contractions

Berchicci¹,

Menotti²,

Macaluso³

et al. 2013

Front. Hum. Neurosci.

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“…During each MVC, participants were verbally encouraged to achieve their maximum and maintain it for at least 2–3 s before relaxing. For both neck flexors and extensors, three MVC attempts were performed, separated by 5 min, and the greatest of the three attempts was chosen as prefatigue (PRE) MVC (Menotti et al., ). Throughout the test, the experimenter visually checked for the presence of compensatory body movements, and, if any, the trial was discarded and a supplementary trial was carried out in a subsequent day.…”

Section: Methodsmentioning

confidence: 99%

Effects of a novel neck balance system on neuromuscular fatigue of neck muscles during repeated flexions and extensions

Quinzi

Giombini

Pigozzi

2018

Hum Ftrs & Erg Mfg Svc

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This study aimed at investigating the effects of a novel neck balance system (NBS), which is a baseball cap with counterweights in the occipital part, on neuromuscular fatigue of neck muscles during and after a full‐range repeated neck flexion‐extension task. Surface electromyography (sEMG) of sternocleidomastoid (SCM) and semispinalis capitis (SC) muscles was recorded in 15 healthy individuals during full‐range flexion‐extension movements of the neck lasting 5 min at a fixed pace (1 Hz), with or without NBS. Maximal isometric force and sEMG were recorded before and after the fatiguing task. During the fatiguing task, the SC muscle showed a higher decline in amplitude of sEMG with NBS than without NBS, while no differences in the SCM muscle emerged between the two conditions. Maximal isometric force of both neck flexor and extensor muscles decreased significantly after the fatiguing task, both with NBS (p < .05) and without NBS (p < .05), with no differences between the two conditions. In conclusion, adopting the NBS promotes an increase of the activation of neck extensor muscles, possibly leading to earlier decline of the neuromuscular performance and to diminished ability to actively stabilize neck structures. For these reasons, the adoption of the NBS during dynamic, fatiguing contractions may not be appropriate.

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“…1999; Menotti et al. 2012), high level of experienced fatigue and impaired recovery from fatigue after exhausting motor tasks (Schillings et al. 2007; Zwarts et al.…”

Section: Introductionmentioning

confidence: 99%

“…2008; Menotti et al. 2012), modification of walking patterns (Don et al. 2007), high energy cost of walking (Menotti et al.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies reported CMT1A patients with several functional limitations: muscle weakness or atrophy in both upper and lower limbs (Lindeman et al 1999;Menotti et al 2012), high level of experienced fatigue and impaired recovery from fatigue after exhausting motor tasks (Schillings et al 2007;Zwarts et al 2008;Menotti et al 2012), modification of walking patterns (Don et al 2007), high energy cost of walking (Menotti et al 2011(Menotti et al , 2013, and low aerobic capacity and cardiovascular fitness (Wright et al 1996;Fowler 2002;Kilmer 2002;El Mhandi et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Amount and intensity of daily living activities in Charcot–Marie–Tooth 1A patients

et al. 2013

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BackgroundCharcot–Marie–Tooth 1A (CMT1A) patients show a reduction of spontaneous activities of daily living measured by means of questionnaires or pedometers, which are quite inaccurate compared to recent measurement techniques.AimThe study aimed at quantifying daily living activities in CMT1A patients by means of inertial sensors, which give information not only on the amount but also on the intensity of these activities.Materials and methodsTime and count (amount), and velocity and power (intensity) of 24 h daily living activities were measured in eight patients (20–48 years; Barthel >90; Tinetti >20) and eight healthy individuals, matched for age and gender, by means of a wearable inertial sensor device.ResultsThere were no differences between patients and controls in the 24-h distance covered and count of steps. However, count of step climbing and sit to stand were lower in patients than in controls (139.93 ± 141.66 vs. 341.06 ± 164.07 n and 58.23 ± 7.82 vs. 65.81 ± 4.75 n, respectively; P < 0.05) as well as mean daily step-climbing and walking velocities (1.07 ± 0.17 vs. 1.21 ± 0.10 m/sec and 1.16 ± 0.31 vs. 1.87 ± 0.50 m/sec, respectively; P < 0.05). In CMT1A patients there was a positive correlation between strength of the knee extensor muscles and both count of steps climbed (R = 0.80) and sit to stand (R = 0.79).Discussion and conclusionThe reduced ability of CMT1A patients to carry out activities at high intensity, which was correlated with strength, suggests that strength training might be a rehabilitation tool for improving the 1 ability to carry out these activities.

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Neuromuscular function after muscle fatigue in Charcot–Marie–Tooth type 1A patients

Abstract: CMT1A patients are not only weaker than healthy individuals in the knee extensors, but they also have impaired neuromuscular recovery after fatigue.

Cited by 24 publications

References 32 publications

The neurophysiology of central and peripheral fatigue during sub-maximal lower limb isometric contractions

The neurophysiology of central and peripheral fatigue during sub-maximal lower limb isometric contractions

Effects of a novel neck balance system on neuromuscular fatigue of neck muscles during repeated flexions and extensions

Amount and intensity of daily living activities in Charcot–Marie–Tooth 1A patients

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