Neuromyelitis Optica Antibodies in Patients With Severe Optic Neuritis in China

Abstract

NMO antibody positivity is relatively high in Chinese patients with severe ON and suggests a poorer visual outcome, probably higher risk of developing spinal cord lesions and a closer association with systemic autoimmune disorders.

Neurological outcome and predictive factors of idiopathic optic neuritis in China

“…However, as with optic neuritis in Western countries, optic neuritis in Asia has been reported to have different clinical features and visual outcomes with typical IDON [6][7][8][9][10][11]. Even so, very few studies have investigated the neurological outcome of optic neuritis in Chinese population, especially in terms of the predictive factors [12][13][14][15]. Herein, we report a retrospective study of the visual and neurological outcomes of a group of idiopathic optic neuritis (ION) patients in Chinese population, with special attention to the conversion to MS or NMO and the related predictive factors.…”

Features of anti-aquaporin 4 antibody-seropositive Chinese patients with neuromyelitis optica spectrum optic neuritis

“…sensitive and specific biomarker for the discrimination of NMO, classic MS, and other neurological diseases [8]. Moreover, poorer visual outcomes during acute ON attacks were found to be more frequent among seropositive patients compared to seronegative patients based on a population of 34 severe ON patients [9].…”

Central nervous system neuroinflammatory disorders in Asian/Pacific regions

“…Among patients with acute monosymptomatic optic neuritis, 13% were seropositive for AQP4 antibodies in Hong-Kong [130], whereas 5.8% were seropositive in Germany [131]. Among patients with severe optic neuritis, 32.4% were seropositive for AQP4 antibodies in China [132], whereas 12% were seropositive in Spain [133 & ]. Isolated optic neuritis has been reported to be common in patients with MOG antibodies [113,115,116,119].…”