Neuromyelitis optica spectrum disorder associated with osmotic demyelination syndrome

Adamec, Ivan; Keršić, Filip; Crnošija, Luka; Habek, Mario

doi:10.1007/s10072-016-2493-1

Cited by 2 publications

(1 citation statement)

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“…Thisplays a critical role in providing metabolic support to the neuron, and helps maintain high efficiency and accuracy in the pulse transmission. Destruction of the myelin sheath is a key pathological feature of numerous CNS disorders, such as multiple sclerosis [1], transverse myelitis [2] and optic neuritis [3]. However, the adult CNS can maintain a capacity for remyelination, but this process often fails under pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation

et al. 2019

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We have previously found that Sirt2 enhanced the outgrowth of cellular processes and MBP expression in CG4 cells, where Sirt2 expression is suppressed by transcription factor Nkx2.2. However, the detailed mechanism of Sirt2 facilitating oligodendroglial cell differentiation remained unclear. In the present study, we observed that Sirt2 partially translocated into the nuclei when CG4 cells were induced to differentiate. Sirt2 was detected at the CpG island of PDGFRα promoter via ChIP assay during the cells differentiation process rather than during the state of growth. Sirt2 deacetylated protein(s) bound to the promoter of PDGFRα and simultaneously appeared to facilitate histone3 K27 tri-methylation, both of which are suppressive signatures on gene transcription activation. In bisulfate assay, we identified that Sirt2 significantly induced DNA methylation of PDGFRα promoter compared with the control. Consistently, Sirt2 overexpression down-regulated PDGFRα expression in CG4 cells. The knock-down of PDGFRα or Sirt2 over-expression repressed cell proliferation, but knock-down of Sirt2 promoted cell proliferation. Taken together, Sirt2 translocated into the nuclei while the cells initiated a differentiation process, facilitating CG4 cell differentiation partially through epigenetic modification and suppression of PDGFRα expression. The repression of PDGFRα expression mediated by Sirt2 appeared to facilitate a transition of cellular processes, i.e. from a proliferating progenitor state to a post-mitotic state in CG4 cells.

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Section: Introductionmentioning

confidence: 99%

Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation

et al. 2019

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Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations

Han

Yang

Zhu

2017

NDT

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Neuromyelitis optica (NMO), considered to be mediated by autoantibodies, often cause severely disabling disorders of the central nervous system, and predominantly cause optic nerve damage and longitudinally extensive transverse myelitis. Remarkable progress has been made in deciphering NMO pathogenesis during the past decade. In 2015, the International Panel for NMO Diagnosis proposed the unifying term “NMO spectrum disorders” (NMOSD) and the updated NMOSD criteria reflects a wide range of disease and maintains reasonable specificity. Moreover, cumulative findings have indicated that NMOSD are frequently associated with multiple autoimmune diseases, thereby presenting complex clinical symptoms that make this disease more difficult to recognize. Notably, most neurologists do not heed these symptoms or comorbid conditions in patients with NMOSD. Whereas previous reviews have focused on pathogenesis, treatment, and prognosis in NMOSD, we summarize the present knowledge with particular emphasis on atypical manifestations and autoimmune comorbidities in patients with NMOSD. Furthermore, we emphasized the identification of these atypical characteristics to enable a broader and better understanding of NMOSD, and improve early accurate diagnosis and therapeutic decision making.

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Neuromyelitis optica spectrum disorder associated with osmotic demyelination syndrome

Cited by 2 publications

References 10 publications

Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation

Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation

Complexity and wide range of neuromyelitis optica spectrum disorders: more than typical manifestations

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