Neuron-Specific Enolase: A Serum Tumor Marker in Malignant Germ-Cell Tumors?

Aj, Gross; Kp, Dieckmann

doi:10.1159/000474309

Cited by 12 publications

(3 citation statements)

References 8 publications

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“…Serum levels of erythropoietin, ferritin, neuron specific enolase and transforming growth factor-b were assayed and have not been found to be of any utility in clinical management of RCC patients [9][10][11][12]. The expression of the tumour proliferation marker Ki-S5 was found to correlate with survival.…”

Section: Diagnostic and Prognostic Biomarkers For Rccmentioning

confidence: 99%

Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutase

et al. 2001

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Renal cell carcinoma (RCC) originates in the renal cortex. It accounts for 2-3 percent of all cancers occurring in adults and it is characterised by lack of early clinical manifestations, unpredictable outcome, and absence of effective treatment modalities except early surgery. RCC comprises a heterogeneous group of tumours with various molecular and cytogenetic abnormalities and different histological features as cell types and tumour architecture. Molecular genetic and proteomic tools led to the discovery of potential diagnostic prognostic and therapeutic biomarkers of RCC. In this review we discuss recent developments in understanding genotype-phenotype relationships, with attention to manganese superoxide dismutase, a mitochondrial enzyme related to the redox cycle which affects various regulatory functions of cells. The expression of this protein has been evaluated in numerous human tumour types including RCC, and post-translational modifications are being investigated.

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Section: Diagnostic and Prognostic Biomarkers For Rccmentioning

confidence: 99%

Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutase

et al. 2001

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“…By changing the level of serum 'abnormality', there might be only 1 false-positive patient. But otherwise, patients with no evidence of renal cell carcinoma had frequently NSE levels up to 10 pg/1 [25]. The wide range of serum values will make standard deviations and standard errors quite large.…”

Section: Discussionmentioning

confidence: 99%

Neuron-Specific Enolase: A Serum Tumor Marker in Renal Cell Carcinoma?

Gross

Michl²,

Bornhöft³

et al. 1993

Eur Urol

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“…22,23 However, large-scale studies have shown frequent false-positive or false-negative results of NSE during follow-up examinations, and thus do not support NSE to be a valuable tumor marker in germ-cell tumors. 24,25 Furthermore, hemolysis leads to an elevation of serum NSE. 25 Accordingly, Sturgeon et al point out that in spite of promising results (30%-50% positivity of patients with seminomas and less often in non-seminomatous germ cell tumor patients), the use of NSE is limited and, so far, only in an experimental stage of development.…”

mentioning

confidence: 99%

Novel tumor markers in the serum of testicular germ cell cancer patients: a review

Syring¹,

Müller²,

Ellinger³

2014

CBF

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Serum tumor markers have an important role in the management of patients with testicular cancer. They are useful for diagnosis, staging and risk assessment, follow-up, evaluation of response, and early detection of relapse. Alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are established serum markers in testicular cancer, but they have a limited sensitivity. Ongoing research may lead to the identification of novel biomarkers. Therefore, we review the experimental analyses for nucleic acids, circulating tumor cells, and proteins as potential biomarkers in the serum of testicular germ cell cancer patients.

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Neuron-Specific Enolase: A Serum Tumor Marker in Malignant Germ-Cell Tumors?

Cited by 12 publications

References 8 publications

Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutase

Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutase

Neuron-Specific Enolase: A Serum Tumor Marker in Renal Cell Carcinoma?

Novel tumor markers in the serum of testicular germ cell cancer patients: a review

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