Neuron-to-microglia Crosstalk in Psychiatric Disorders

Lee, Youn Jung; Kim, Yong Ku

doi:10.2174/1570159x1802200109163818

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Natural products and their bioactive molecules have been widely shown as successful and promising sources of potential drug leads in the development of medications for the treatment of AD [ 19 , 20 ]. In this respect, mixtures or extracts of natural products contain natural bioactive molecules that could be a potential therapeutic strategy for treating or preventing AD [ 21 – 23 ]. Furthermore, several extracts and natural sources are broadly used in animal models and clinical trials to cure AD [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Islam

Khadija

Harun-Or-Rashid

et al. 2022

Oxidative Medicine and Cellular Longevity

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Alzheimer’s disease (AD) is a common neurodegenerative brain disorder that causes cellular response alterations, such as impaired cholinergic mechanism, amyloid-beta (Aβ) AD aggregation, neuroinflammation, and several other pathways. AD is still the most prevalent form of dementia and affects many individuals across the globe. The exact cause of the disorder is obscure. There are yet no effective medications for halting, preventing, or curing AD’s progress. Plenty of natural products are isolated from several sources and analyzed in preclinical and clinical settings for neuroprotective effects in preventing and treating AD. In addition, natural products and their derivatives have been promising in treating and preventing AD. Natural bioactive compounds play an active modulatory role in the pathological molecular mechanisms of AD development. This review focuses on natural products from plant sources and their derivatives that have demonstrated neuroprotective activities and maybe promising to treat and prevent AD. In addition, this article summarizes the literature pertaining to natural products as agents in the treatment of AD. Rapid metabolism, nonspecific targeting, low solubility, lack of BBB permeability, and limited bioavailability are shortcomings of most bioactive molecules in treating AD. We can use nanotechnology and nanocarriers based on different types of approaches.

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Section: Introductionmentioning

confidence: 99%

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Islam

Khadija

Harun-Or-Rashid

et al. 2022

Oxidative Medicine and Cellular Longevity

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show abstract

“…The heating and combustion treatments were carried out in a muffle furnace (KO TSAO Ltd., Taiwan). The H 2 O 2 concentration was analyzed by colorimetric determination [33] with a potassium permanganate redox titration method [34] between 470-520 nm using a spectrophotometer (DR-4000, HACH, USA). Each experiment in this study was performed at least three replicates.…”

Section: Methodsmentioning

confidence: 99%

Application of Fenton Method for the Removal of Organic Matter in Sewage Sludge at Room Temperature

et al. 2020

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Cement is the most widely used construction material in the world. However, its manufacture is high energy consumption and high carbon emission owing to the high temperature calcination process. Geopolymer is an ideal alternative material for cement because it has a similar structure and performance to cement. In addition, it can be synthesized at room temperature and thus has the advantages of energy saving and carbon emission reduction. Sewage sludge (SS) can be used as raw material for geopolymer synthesis. However, the high organic matter content in SS lowers the mechanical strength of geopolymer. Although the organic matter in SS can be removed by incineration at high temperature, this consumes energy and emits carbon dioxide, which diminishes the advantages of geopolymer. In this study, the Fenton method was applied for the removal of organic matter in SS at room temperature. The parameters of the Fenton method, including the dosages of hydrogen peroxide (H 2 O 2 ) and Fe 2+ reagent (FeSO 4 ·7H 2 O), reaction time, and initial pH value, were investigated. The results indicated that 83.7% of the organic matter in SS could be removed at room temperature by using 5.15 M H 2 O 2 and 5.15 mM FeSO 4 ·7H 2 O at pH 7, which suggested the possibility of sewage sludge reclamation through geopolymer synthesis as an alternative material for cement toward sustainability.

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The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis

Liu

Shao

et al. 2023

Brain, Behavior, and Immunity

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Neuron-to-microglia Crosstalk in Psychiatric Disorders

Cited by 3 publications

References 17 publications

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Bioactive Compounds and Their Derivatives: An Insight into Prospective Phytotherapeutic Approach against Alzheimer’s Disease

Application of Fenton Method for the Removal of Organic Matter in Sewage Sludge at Room Temperature

The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis

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