Neuronal activity in the vestibular nuclei of the alert monkey during vestibular and optokinetic stimulation

Waespe, W.; Henn, Volker

doi:10.1007/bf00239041

Cited by 553 publications

(152 citation statements)

References 24 publications

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“…The results of both sessions of Experiment 3 are consistent with a neurophysiological model of visualvestibular interactions (Dichgans & Brandt, 1978;Waespe & Henn, 1977). In this approach, peripheral receptive fields are assumed to process the image of the tilted frame patterns.…”

Section: Resultssupporting

confidence: 78%

Absence of relational determination in the rod-and-frame effect

Ebenholtz

1985

Perception & Psychophysics

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. InRelational features between a rod and frame that might facilitate an angle-detection process were manipulated in two ways: first, by varying rod lengths with retinal eccentricities of 3.8 0 ,7.5 0 , and 14.8 0 in a frame with inner dimensions of 35.3°x 35.3°, and second, by eliminating the sides, leaving only the corners of the frame. The converse case, in which corners were eliminated but sides left intact, represented the control condition. In neither case did the opportunity to use relational features enhance the rod-and-frame effect (RFE). In a frame with inner dimensions of 52.5°x 52.5 0 , when line length had an eccentricity of about 25 0, reducing it to 3 0 did significantly reduce the RFE, but only for those who scored in the upper 50% as measured on the full-frame RFE. An explanation is proposed based upon visual-vestibular interactions between receptive fields in peripheral retina and orientation detectors in the vestibular nucleus.

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Section: Resultssupporting

confidence: 78%

Absence of relational determination in the rod-and-frame effect

Ebenholtz

1985

Perception & Psychophysics

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“…The dynamics of thalamic neurons are similar to those previously reported in eye movementinsensitive VN neurons (Fig. 2 B) (Waespe and Henn, 1977;Dickman and Angelaki, 2004). Notably, like VN neurons, but unlike canal afferents, thalamic neurons showed little increase in phase lead, and only a relatively small drop in gain during low frequency rotations (Fig.…”

Section: Responses During Rotationsupporting

confidence: 85%

Vestibular Signals in Primate Thalamus: Properties and Origins

Hui¹,

May²,

Dickman³

et al. 2007

J. Neurosci.

131

162

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“…Single-neuron recordings in a variety of mammalian species have demonstrated that optokinetic and vestibular signals converge at the level of the second-order vestibular neurons (i.e., vestibular nucleus neurons receiving direct inputs from the vestibular nerve) (Hamann and Lannou 1987;Keller and Precht 1978;Precht and Cazin 1979;Stahl and Simpson 1995;Waespe and Henn 1977). The observation that bilateral labyrinthectomy transiently suppresses optokinetic responses has also been interpreted as indicating that secondary vestibular neurons serve as an important conduit for optokinetic signals.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Vestibular Dysfunction in the Mouse Model for Usher Syndrome 1F

Alagramam

Stahl

Jones

et al. 2005

JARO

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The deaf-circling Ames waltzer (av) mouse harbors a mutation in the protocadherin 15 (Pcdh15) gene and is a model for inner ear defects associated with Usher syndrome type 1F. Earlier studies showed altered cochlear hair cell morphology in young av mice. In contrast, no structural abnormality consistent with significant vestibular dysfunction in young av mice was observed. Light and scanning electron microscopic studies showed that vestibular hair cells from presumptive null alleles Pcdh15 av-Tg and Pcdh15 av-3J are morphologically similar to vestibular sensory cells from control littermates, suggesting that the observed phenotype in these alleles might be a result of a central, rather than peripheral, defect. In the present study, a combination of physiologic and anatomic methods was used to more thoroughly investigate the source of vestibular dysfunction in Ames waltzer mice. Analysis of vestibular evoked potentials and angular vestibulo-ocular reflexes revealed a lack of physiologic response to linear and angular acceleratory stimuli in Pcdh15 mutant mice. Optokinetic reflex function was diminished but still present in the mutant animals, suggesting that the defect is primarily peripheral in nature. These findings indicate that the mutation in Pcdh15 results in either a functional abnormality in the vestibular receptor organs or that the defects are limited to the vestibular nerve. AM1-43 dye uptake has been shown to correlate with normal transduction function in hair cells. Dye uptake was found to be dramatically reduced in Pcdh15 mutants compared to control littermates, suggesting that the mutation affects hair cell function, although structural abnormalities consistent with significant vestibular dysfunction are not apparent by light and scanning electron microscopy in the vestibular neuroepithelia of young animals.

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Neuronal activity in the vestibular nuclei of the alert monkey during vestibular and optokinetic stimulation

Cited by 553 publications

References 24 publications

Absence of relational determination in the rod-and-frame effect

Absence of relational determination in the rod-and-frame effect

Vestibular Signals in Primate Thalamus: Properties and Origins

Characterization of Vestibular Dysfunction in the Mouse Model for Usher Syndrome 1F

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