Neuronal connections of the paratrigeminal nucleus: a topographic analysis of neurons projecting to bulbar, pontine and thalamic nuclei related to cardiovascular, respiratory and sensory functions

Caous, Cristofer André; Buck, Hudson Sousa; Lindsey, Charles Julian

doi:10.1016/s1566-0702(01)00338-1

Cited by 76 publications

(31 citation statements)

References 30 publications

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“…The afferent and efferent organization of the dPa5 region differs considerably from the vl-Vi/Vc transition in that it receives direct sensory input from trigeminal, upper cervical and vagus nerve fibers and projects to multiple medullary and pontine regions that control autonomic outflow including the NTS and CVLM (Menetrey and Basbaum 1987; Saxon and Hopkins 1998; Caous et al 2001). Similar to the response at caudal Vc, TMJ-evoked Fos-LI at the dPa5 increased with greater stimulus intensity, was mainly ipsilateral to the stimulus and was enhanced by high estrogen conditions (Bereiter 2001; Okamoto et al 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Lesion of the dPa5 prevented cardiovascular reflex responses to noxious stimuli (Yu et al 2002), while recording studies found that dPa5 neurons encoded facial skin stimulus intensity and became sensitized after TMJ injury (Yamazaki et al 2008). Although the dPa5 likely is critical for somatic autonomic integration in the trigeminal system (Saxon and Hopkins 1998; Caous et al 2001), these studies were performed in male animals, and thus, it is not known if sex differences influence the contribution of dPa5 to TMJ nociceptive processing.…”

Section: Discussionmentioning

confidence: 99%

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Differential ascending projections of temporomandibular joint-responsive brainstem neurons to periaqueductal gray and posterior thalamus of male and female rats

2012

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Several craniofacial pain conditions including temporomandibular joint disorders (TMJD) are more prevalent in women than men. The basis for sex differences in deep craniofacial pain is not known. The present study compared the magnitude of ascending projections from TMJ-responsive neurons in trigeminal brainstem to the ventrolateral periaqueductal gray (vlPAG) or posterior nucleus of the thalamus (Po) in males and female rats. Fluorogold (FG) was injected into vlPAG or Po and TMJ-responsive neurons were identified by Fos-like immunoreactivity (Fos-LI) after mustard oil injection. TMJ-evoked Fos-LI was similar in males and females; however, significant differences in cell counts were seen for FG single-labeled and Fos/FG double-labeled neurons in trigeminal brainstem. After vlPAG injections, the number of FG-labeled neurons in trigeminal subnucleus interpolaris (Vi), ventral interpolaris/caudalis transition (vl-Vi/Vc) and dorsal paratrigeminal region (dPa5) was greater in females than males. The percentage of Fos/FG double-labeled neurons in vl-Vi/Vc and dPa5 after vlPAG injection also were greater in females than males. By contrast after Po injections, males displayed a greater number of FG-labeled neurons in superficial laminae of Vc and C1–2 and deeper laminae at C1–2 than females. The percentage of Fos/FG double-labeled neurons in superficial laminae of Vc after Po injection also was greater in males than females. These data revealed significant sex differences in ascending projections from TMJ-responsive neurons in trigeminal brainstem. Such differences may influence the ability of males and females to recruit autonomic reflexes and endogenous pain control circuits relevant for TMJ nociception.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differential ascending projections of temporomandibular joint-responsive brainstem neurons to periaqueductal gray and posterior thalamus of male and female rats

2012

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“…NTS neurons have dense reciprocal innervation with the trigeminal complex and facial motor nucleus (Zerari-Mailly et al, 2005); activation of trigeminal and facial nerves during intense headaches/migraine/dental pain activates parasympathetic reflexes that regulate cardiovascular, GI and respiratory functions, including emesis (Caous et al, 2001). As described earlier, NTS neurons can be activated following noxious stimulation of gastrointestinal vagal afferents (Randich and Gebhart, 1992; Renehan et al, 1995; Traub et al, 1996) although nociceptive inputs more often activate NTS neurons via spinal pathways (Boscan et al, 2002; Pickering et al, 2003a, 2003b).…”

Section: Role Of Vagal Neurocircuitry In Nausea and Vomitingmentioning

confidence: 99%

The role of vagal neurocircuits in the regulation of nausea and vomiting

Babic

Browning

2014

European Journal of Pharmacology

182

143

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Nausea and vomiting are among the most frequently occurring symptoms observed by clinicians. While advances have been made in understanding both the physiological as well as the neurophysiological pathways involved in nausea and vomiting, the final common pathway(s) for emesis have yet to be defined. Regardless of the difficulties in elucidating the precise neurocircuitry involved in nausea and vomiting, it has been accepted for over a century that the locus for these neurocircuits encompasses several structures within the medullary reticular formation of the hindbrain and that the role of vagal neurocircuits in particular are of critical importance. The afferent vagus nerve is responsible for relaying a vast amount of sensory information from thoracic and abdominal organs to the central nervous system. Neurons within the nucleus of the tractus solitarius not only receive these peripheral sensory inputs but have direct or indirect connections with several other hindbrain, midbrain and forebrain structures responsible for the co-ordination of the multiple organ systems. The efferent vagus nerve relays the integrated and co-ordinated output response to several peripheral organs responsible for emesis. The important role of both sensory and motor vagus nerves, and the available nature of peripheral vagal afferent and efferent nerve terminals, provides extensive and readily accessible targets for the development of drugs to combat nausea and vomiting.

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“…The kallikrein-kinin system, of which bradykinin is the main representative, has raised interest, in view of the signaling pathways in which this peptide acts. B 2 bradykinin receptor has been found in many cell types such as vascular endothelium, primary sensory afferent neurons, vascular smooth muscle and non-vascular, epithelial cells, and perhaps in certain types of leukocytes, which gives bradykinin a wide physiological activities such as vasodilatation, increased vascular permeability, stimulation of sympathetic and sensory nerves connection (Coelho et al, 1997;Caous et al, 2001;. The B2 kinin receptor has constitutive expression being relatively stable, regulated only by the transcription factor affinity for the promoter site of the gene (Pesquero et.…”

Section: Discussionmentioning

confidence: 99%

“…The marking ion binding sites was observed in the fibers terminals associated with synaptic buttons in the nucleus ambiguus, and rostral ventrolateral nucleus (RVL) (Finley & Katz, 1992). Among the nuclei of the ventral medulla, for whom PA5 projections, the RVL is the most involved with the control of vasomotor tone (Caous et al, 2001). The spinal vestibular nucleus (SpVe), was analyzed by tracer and highlighted its connections to the spinal cord (Liang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Expression and Distribution of Kinin B2 Receptor in Medulla and Spinal Cord Tissues of Rats Treated with Capsaicin

França¹,

Guardabassi

Smith

2016

Int. J. Morphol.

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SUMMARY:Kinins are vasoactive peptides that promote pain and inflammation, yet centrally believed to participate to cardiovascular defensive reflexes produced by noxious stimuli. These peptides signal through the activation of two transmembrane Gprotein-coupled receptors named B 1 and B 2 receptors (B 1 R and B 2 R). The B 2 R is constitutive in healthy tissues and animals. The aim of the study was to measure the gene and protein expression of B 2 R kinin receptors in central and peripheral tissues isolated from control rats and rats were pre-treated with capsaicin on the second day of life (50 mg/kg, s.c.) or two weeks prior to sacrifice (125 mg/kg over three days, s.c.). The same treatment with saline was made in control animals. Levels of mRNA for B 2 R were measured by quantitative RT-PCR and Qualitative while receptor binding sites were measured on tissue sections with the radioligands 125 I-HPP-Hoe 140 (B 2 R). B 2 R was expressed in all studied tissues (hypothalamus, paratrigeminal nucleus, nucleus of solitary tract, spinal cord, aorta and liver) and treatment capsaicin neonates when compared to controls, did not affect its level of expression. Capsaicin had no significant effect on the expression of B 2 R in some tissues on binding sites. The synthesis of B2R kinin receptor is not associated with sensory C-fibre and tissues showed no significant difference indicating that B 2 R was regulated by distinct mechanisms.

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Neuronal connections of the paratrigeminal nucleus: a topographic analysis of neurons projecting to bulbar, pontine and thalamic nuclei related to cardiovascular, respiratory and sensory functions

Cited by 76 publications

References 30 publications

Differential ascending projections of temporomandibular joint-responsive brainstem neurons to periaqueductal gray and posterior thalamus of male and female rats

Differential ascending projections of temporomandibular joint-responsive brainstem neurons to periaqueductal gray and posterior thalamus of male and female rats

The role of vagal neurocircuits in the regulation of nausea and vomiting

Expression and Distribution of Kinin B2 Receptor in Medulla and Spinal Cord Tissues of Rats Treated with Capsaicin

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