Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease

Nikaki, Kornilia; Sawada, Akinari; Ustaoglu, Ahsen; Sifrim, Daniel

doi:10.1007/s11894-019-0728-z

Cited by 26 publications

(15 citation statements)

References 126 publications

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“…SGB can induce reflux, the mechanism of which is unclear ( Figure 1 B). There are three possibilities as follows: (1) SGB-induced esophageal distension might provoke A TLESR [ 37 , 38 ], (2) AN INCREASE IN abdominal pressure might bring up the gastric contents through the LES, (3) TLESR might elicit a reflex of UES relaxation, which IN TURN lets the air into the esophagus [ 39 ]. Glasinovic et al showed that 26% of total acid exposure time is caused by SGB-induced reflux in GERD patients with excessive SGB [ 3 ].…”

Section: Belching and Gastroesophageal Reflux Diseasementioning

confidence: 99%

Belching in Gastroesophageal Reflux Disease: Literature Review

Fujiwara

Sifrim

2020

JCM

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Belching is a common phenomenon. However, it becomes bothersome if excessive. Impedance–pH monitoring can classify the belching into two types: gastric belching and supragastric belching (SGB). The former is a physiological mechanism to vent swallowed air from the stomach, whereas the latter is a behavioral disorder. Gastroesophageal reflux disease (GERD) is the most relevant condition in both types of belching. Recent findings have raised awareness that excessive SGB possibly sheds light on the pathogenesis of a part of proton pump inhibitor (PPI) refractoriness in GERD. SGB could cause typical reflux symptoms such as heartburn, regurgitation or chest pain in two ways: SGB-induced gastroesophageal reflux or SGB-induced esophageal distension. In PPI-refractory GERD, it is important to detect hidden SGB as a cause of reflux symptoms since SGB requires psychological treatment instead of high dose PPIs or pain modulators. In the case of PPI-refractory GERD with excessive SGB, recent studies imply that the combination of a psychological approach and conventional treatment can improve treatment outcome.

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Section: Belching and Gastroesophageal Reflux Diseasementioning

confidence: 99%

Belching in Gastroesophageal Reflux Disease: Literature Review

Fujiwara

Sifrim

2020

JCM

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“…17,[21][22][23] Secondary peristalsis functions to clear the esophagus of retained or refluxed esophageal contents and maintain an empty esophagus. 21,22,[24][25][26] On the other hand, primary peristalsis (which is typically evaluated by HRM) is the principle form of esophageal motility triggered by swallowing that facilitates bolus transit to the stomach. 11 Similar to primary peristalsis, abnormal secondary peristalsis can lead to dysphagia and pathologic acid reflux.…”

Section: Physiologic Parameters and Motility Patterns Obtained By Flipmentioning

confidence: 99%

Functional Luminal Imaging Probe (FLIP) as an Adjunctive Modality in Evaluation of Esophageal Dysmotility

Farina

Carlson

2021

Foregut: The Journal of the American Foregut Society

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The Functional Luminal Imaging Probe (FLIP) has emerged as a valuable adjunctive tool in the evaluation of esophageal diseases. Using volumetric distension, FLIP can assess secondary peristalsis and detect esophageal abnormalities that may not be evaluated by high-resolution manometry (HRM). In certain clinical settings, FLIP may allow for deferral of HRM. In therapy for esophageal diseases, FLIP has demonstrated value for its real-time interpretation, which can be used intra-procedurally to tailor therapy and to predict post-therapy outcomes. The future of FLIP looks promising as surgeons and gastroenterologists place increasing emphasis on non-manometric data to diagnose esophageal motility disorders.

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“…Основные нарушения перистальтики: спастические нарушения двигательной функции пищевода (дистальный эзофагоспазм, гиперконтрактильный пищевод) и отсутствие перистальтики В основе регуляции моторики пищевода лежит взаимодействие нервных и гуморальных факторов. При нарушении координированного действия тормозящих и возбуждающих систем регуляции возникает патологическая сократительная активность, проявляющаяся гипер-или гипомоторной дискинезией [35,36].…”

Section: нарушения двигательной функции грудного отдела пищеводаunclassified

Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders

Ивашкин

Маев

Трухманов

et al. 2020

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. Current recommendations of the Russian Gastroenterological Association on clinical use of high-resolution manometry in diagnosis of esophageal disorders are intended to assist in clinical decision making, terminology standardisation and interpretation of clinical data.Key points. In 2018, a joint meeting of the Russian Gastroenterological Association and Russian Neurogastroenterology and Motility Group approved unified terminology and classification of esophageal motor function disorders for high-resolution manometry diagnosis.Gastrointestinal patient complaints typically concern esophageal disorders such as dysphagia, regurgitation, heart-burn, chest pain or belching. To exclude erosive and ulcerative lesions, eosinophilic esophagitis and organic changes, esophagogastroduodenoscopy and biopsy are recommended in pre-treatment. Upon excluding mucosal lesions and esophageal lumen obstruction as causal for symptoms, use of high-resolution manometry is recommended. This method of esophageal examination has become the “gold standard” in diagnosis of motor disorders.High-resolution manometry enables detailed investigation of integral quantitative and qualitative characteristics of esophagus motor function and specific related disorders, analysis of esophageal contractile propagation and strictly coordinated synchronous peristalsis of upper esophageal sphincter, esophagus and lower esophageal sphincter, which malfunction may provoke development of achalasia, esophagospasm, hiatal hernia, ineffective eso pha geal motility and other motor disorders.Conclusion. High-resolution manometry is a relatively new method for study of esophagus motor function gaining increasingly wide application in clinical practice. It enables a medical professional to obtain evidence that may critically affect the choice of optimal patient care strategy and effective treatment. Current recommendations are based on an extensive review of up-to-date information and will be updated with new corpus of clinical data and assessment emerging in evidential medicine to provide gastroenterologists country-wide with latest scientific and practical guidelines.

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Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease

Cited by 26 publications

References 126 publications

Belching in Gastroesophageal Reflux Disease: Literature Review

Belching in Gastroesophageal Reflux Disease: Literature Review

Functional Luminal Imaging Probe (FLIP) as an Adjunctive Modality in Evaluation of Esophageal Dysmotility

Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders

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