Neuronal localization of substance P receptors in rat neostriatum

Ritter, Joseph K.; Gehlert, Donald R.; Gibb, James W.; Wamsley, James K.; Hanson, Glen R.

doi:10.1016/0014-2999(85)90409-1

Cited by 11 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionsupporting

confidence: 93%

“…However, neither a single administration of the low or high dose of METH altered the nigral content of SPLI. This lack of a nigral effect was consistent with previous reports that a single administration of METH does not alter nigral SPLI tissue levels (Ritter et al 1985). While the patterns of change in SPLI tissue levels confirmed the observation from the microdialysis studies that basal ganglia SP systems are differentially affected by low and high METH doses, it was not clear how the drug-induced effect on SP release (observed within 0.5-3 h) after drug exposure was linked to the changes observed in SPLI tissue levels at 12 h after treatment.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Distinct responses of basal ganglia substance P systems to low and high doses of methamphetamine

Hanson

Bush

Keefe

et al. 2002

Journal of Neurochemistry

Self Cite

View full text Add to dashboard Cite

Substance P (SP) is a neuropeptide closely associated with basal ganglia dopaminergic neurons. Because some neuropeptide systems in the basal ganglia (i.e. neurotensin and metenkephalin) are differentially affected by treatment with low or high doses of methamphetamine, we determined if basal ganglia SP pathways were also differentially influenced in a dose-dependent manner by this psychostimulant. Employing in vivo microdialysis, it was observed that the low dose (0.5 mg/kg) of methamphetamine increased the extracellular concentration of SP in the substantia nigra, but not in globus pallidus or striatum. In contrast, the high dose (10 mg/kg) of methamphetamine did not increase extracellular SP content in any of these structures. The effect of the low-dose methamphetamine treatment on nigral extracellular SP levels was blocked by pre-treatment with either a D 1 or D 2 antagonist. In addition, 12 h after similar methamphetamine treatments, a dose-dependent differential response in SP tissue levels occurred in some of the regions examined. When these changes occurred, the low dose of methamphetamine usually reduced, whereas the high dose increased, SP tissue content. This study demonstrated opposite responses of the basal ganglia SP system to low and high doses of methamphetamine and suggested that a combination of dopamine D 1 and D 2 receptor activity contributed to these effects.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Distinct responses of basal ganglia substance P systems to low and high doses of methamphetamine

Hanson

Bush

Keefe

et al. 2002

Journal of Neurochemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Thus, the blockade of ACh release evoked by SEP and NKA is probably due to the TTX blockade of axonal transmission following somatodendritic activation of cholinergic neurons, as has been previously reported for ACh release evoked by glutamate (Scatton and Lehmann, 1982;Arenas et al, 1990a). Furthermore, lesion studies using kainate and 6-OHDA showed that SP binding sites in the neostriatum were mainly located on striatal cell bodies and dendrites rather than on afferent nerve terminals (Ritter et al, 1985;Mantyh and Hunt, 1986). These results have been confirmed by the TTX sensitivity of 3H-dopamine release evoked by SP in striatal slices, which involves polysynaptic paths and suggests the absence of SP receptors on dopaminergic terminals (Petit and Glowinski, 1986).…”

Section: Discussionmentioning

confidence: 68%

Neurokinin receptors differentially mediate endogenous acetylcholine release evoked by tachykinins in the neostriatum

et al. 1991

View full text Add to dashboard Cite

The regulation of neostriatal cholinergic function by tachykinins (TKs) has been studied by measuring endogenous ACh released from rat neostriatal slices. Septide (SEP; a highly selective substance P analog), neurokinin A (NKA), and neurokinin B (NKB) elicited endogenous ACh release in a concentration-dependent manner. The rank order in potency was the following: NKB (EC50 approximately 0.5 nM) greater than NKA (EC50 approximately 7 nM) greater than SEP (EC50 approximately 12 nM). Spantide (SPA) was less effective (39% inhibition) than [D-Arg6, D- Trp7,9, N-Methyl-Phe8]-substance P fragment 6–11 (53% inhibition) at antagonizing ACh release evoked by SEP and NKA. Smaller doses of the antagonists inhibited the effects of SEP compared to NKA, and the effects of NKB could only be antagonized by SPA. These findings suggest the involvement of the three neurokinin (NK) receptors in ACh release evoked by TKs with the following rank order: NK3 greater than NK2 greater than NK1. 6-Hydroxydopamine lesions of nigrostriatal neurons and tetrodotoxin (TTX) intoxication of striatal tissue revealed two different patterns of regulation of cholinergic function by TKs. On the one hand, SEP and NKA evoked ACh release, independently of the nigrostriatal dopaminergic system, by acting on NK1 and NK2 receptors that are probably localized on the somatodendritic field of cholinergic neurons receiving substance P terminals. On the other hand, dopaminergic terminals seem to regulate NKB neurons that modulate cholinergic neurons, because NKB-evoked ACh release decreased by 24% in the denervated striata. In addition, TTX partially blocked (50%) ACh release evoked by NKB, suggesting that NKB acts on NK3 receptors at both the nerve terminals and the somatodendritic field of cholinergic neurons.

show abstract

Neuropeptides Receptors Changes in Huntington’s Chorea Basal Ganglia are Unrelated to Changes in Neuropeptides Levels

Chinaglia

Álvarez

Probst

et al. 1991

Advances in Behavioral Biology

View full text Add to dashboard Cite

Neuronal localization of substance P receptors in rat neostriatum

Cited by 11 publications

References 4 publications

Distinct responses of basal ganglia substance P systems to low and high doses of methamphetamine

Distinct responses of basal ganglia substance P systems to low and high doses of methamphetamine

Neurokinin receptors differentially mediate endogenous acetylcholine release evoked by tachykinins in the neostriatum

Neuropeptides Receptors Changes in Huntington’s Chorea Basal Ganglia are Unrelated to Changes in Neuropeptides Levels

Contact Info

Product

Resources

About