Neuronal nitric oxide synthase gene polymorphism and IgE‐mediated allergy in the Central European population

Abstract

Our findings suggest that NOS1 gene may participate in the pathogenesis of high total serum IgE levels in allergic diseases in our population. These findings provide support for NOS1 as a candidate gene for IgE-mediated allergy.

Haplotype analysis of the endothelial nitric oxide synthase gene in asthma

“…In a recent study we observed a significant interaction between eNOS-786C/T variant and gender [25]. Previously, our group studied polymorphic markers in nNOS (C5266T) and iNOS (several variants mainly in promoter region) genes and reported significant associations between the nNOS variant and plasma IgE [41], similar to that between iNOS haplotypes and asthma [42]. However, this study also has several strengths.…”

A NOS1 Gene Polymorphism Associated with Asthma and Specific Immunoglobulin E Response to Mite Allergens in a Colombian Population

“…NOS1 gene, by means of the C5266T SNP, has also been associated with total IgE levels in Caucasian and Chinese populations [13, 29, 30]. Furthermore, in Chinese subjects this polymorphism was also associated with specific IgE to D. pteronyssinus, as detected by skin test [13].…”

“…NOS1 polymorphisms have been associated with asthma [9, 27, 28], IgE levels [13,29,30,31] and exhaled NO concentration [32]. The three studies showing association with asthma were performed in Caucasian and Japanese populations, two of them with the NOS1 intron 2 CA repeat and the other with the exon 29 CA repeat.…”

The role of genetics in the development of asthma and atopy

“…Studies have been reported that SNPs in NOS1 are associated with asthma, eosinophil counts and total serum IgE levels [13 ]. Holla, et al [48] confirmed that SNPs in NOS1 are associated with IgE-mediated allergy in a Central European population [48].…”