Neurone‐specific enolase and <i>N</i>‐acetyl‐aspartate as potential peripheral markers of ischaemic stroke

Stevens, Henk; Jakobs, Cornelis; Jager, Aej de; Cunningham, R. T.; Korf, J

doi:10.1046/j.1365-2362.1999.00408.x

Cited by 41 publications

(35 citation statements)

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“…Previous studies have reported increased plasma or serum neurobiochemical markers, e.g., S-100 protein, neuron-specific enolase, and N-acetylaspartate, in the peripheral circulation of patients after stroke but failed to demonstrate that these markers offered any additional advantage over current clinical assessment scales, risk factors, or neuroradiologic techniques (5)(6)(7)(8). Correlations have been observed between marker values, infarct size, and NIHSS scores, and increased concentrations predict disability and mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The blood-brain barrier is compromised in many patients with stroke, and the liberation of neurobiochemical protein markers into the circulation may allow the pathophysiology, progress, and prognosis of patients with cerebrovascular disease to be further evaluated (5)(6)(7)(8). Although increased concentrations of several neurobiochemical protein markers have been detected in the peripheral blood of patients with stroke, to date none has found a place in clinical practice.…”

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confidence: 99%

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Prognostic Use of Circulating Plasma Nucleic Acid Concentrations in Patients with Acute Stroke

et al. 2003

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Background: At present there is no simple, accurate blood test that may be used to determine the severity of stroke or to predict mortality and morbidity in stroke patients presenting to emergency departments. Methods: Patients with stroke-like symptoms who presented to an emergency department of a university hospital in Hong Kong were recruited for the study. DNA extracted from patients' plasma was analyzed for the ␤-globin gene with a fluorescent-based PCR test. The primary outcome measures were in-hospital and 6-month mortality and morbidity using the post-stroke modified Rankin Score. Results: Among the 88 consecutive patients recruited to the study, 70 (80%) had ischemic stroke, 11 (13%) had intracerebral hemorrhage, and 7 (8%) had transient ischemic attacks. Median plasma DNA concentrations taken within 3 h of symptom onset were higher in patients who died compared with those who survived at discharge (6205 vs 1334 kilogenome-equivalents/L; P ‫؍‬ 0.03). Among patients with NIH Stroke Scale scores >8, median plasma DNA concentrations were higher in patients who died compared with those who survived to 6 months (2273 vs 968 kilogenome-equivalents/L; P ‫؍‬ 0.002). Plasma DNA concentrations correlated with the volume of cerebral hematoma (r ‫؍‬ 0.66; P ‫؍‬ 0.03). Plasma DNA concentrations >1400 kilogenome-equivalents/L had a sensitivity of 100% and a specificity of 74.4% for predicting hospital mortality after stroke, and the area under the ROC curve was 0.89 (95% confidence interval, 0.80 -0.94). The adjusted odds ratio for plasma DNA concentrations predicting 6-month mortality was

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Prognostic Use of Circulating Plasma Nucleic Acid Concentrations in Patients with Acute Stroke

et al. 2003

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“…Animal experiments have verified that plasma NSE begins rising within 2 hr of ischemia, and continues for 2.5 days (Barone et al., 1993). Stevens, Jakobs, de Jager, Cunningham, and Korf (1999) observed that in 19 patients with acute cerebral embolism, serum NSE levels increased within 4 hr of the attack. Gruener, Gross, Gozlan, and Barak (1994) found that NSE levels in blood and CSF of patients with acute stroke reached peak values after 7 days.…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory factors related to acute isolated vertigo or dizziness and cerebral infarction

et al. 2018

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ObjectiveTo clarify the relationship of clinical factors with isolated vertigo or dizziness of cerebrovascular origin.MethodsClinical data of patients admitted in East Hospital from Jan. 2015 to Apr. 2016, whose complaint were acute vertigo or dizziness were retrospectively collected. All patients arrived at the emergency department within 24 hr of symptom onset, had no acute ischemic lesion first CT and NIHSS score of 0. Patients were divided into cerebral infarction group and noncerebral infarction group according to subsequent cerebral imaging results and clinical and laboratory factors related to cerebral infarction were analyzed.Result51.6% of patients were female (n = 141). 46 patients (16.8%) were diagnosed with acute cerebral infarction. Baseline demographic data of the two groups was not significantly different. Univariate analysis found that history of smoking (p = 0.009), headache (p = 0.028), unsteadiness (p = 0.009), neuron specific enolase (p = 0.001), and vertebral artery abnormalities found on imaging (p = 0.009) were the significant difference between two groups. Increased neuron specific enolase (p = 0.005) and an abnormal vertebral artery (p = 0.044) were significant on multivariate analysis.Conclusions16.8% of acute isolated vertigo or dizziness presentations were diagnosed with acute cerebral infarction. Increased serum neuron specific enolase and vertebral artery abnormalities were the strongest indicators of acute cerebral infarction.

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“…Stevens et al [12], Hill et al [13], Schaarschmidt et al [14] have demonstrated an increase in serum NSE level after acute focal ischemia in humans.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Brain Biomarker Neuron Specific Enolase (NSE) with Degree of Disability and Neurological Worsening in Cerebrovascular Stroke

Bharosay

Varma

et al. 2011

Ind J Clin Biochem

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Stroke is the third major cause of death and foremost cause of disability worldwide. Cerebrovascular stroke remains largely a clinical diagnosis. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of neurobiochemical marker of brain damage (neuron-specific enolase [NSE]) with respect to degree of disability at the time of admission and neurological worsening in acute ischemic stroke patients. We investigated 150 patients with cerebrovascular stroke who were admitted within 72 h of onset of stroke in the Department of Neurology at SAIMS. Venous blood samples were taken after admission and NSE was analyzed by solid enzyme linked immunosorbent assay using Analyzer and microplate reader from Biored: Code 680. In all patients, the neurological status was evaluated by a standardized neurological examination and the National Institutes of Health Stroke Scale on admission and on day 7. Serum NSE concentration was found to significantly correlate with both degree of disability and neurological worsening in acute ischemic stroke cases in the present study. The maximum serum NSE level within 72 h of admission was significantly higher in patients with greater degree of disability at the time of admission. Serum NSE levels were also found to be significantly elevated in patients with bad neurological outcome. Our study showed that serum NSE has high predictive value for determining severity and early neurobehavioral outcome after acute stroke.

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Neurone‐specific enolase and N‐acetyl‐aspartate as potential peripheral markers of ischaemic stroke

Abstract: Serum N-acetyl-aspartate appears to be an early peripheral marker of ischaemically affected brain neurones, and the ratio of N-acetyl-aspartate to a protein marker, such as NSE, may serve as an index of irreversibility.

Cited by 41 publications

References 30 publications

Prognostic Use of Circulating Plasma Nucleic Acid Concentrations in Patients with Acute Stroke

Prognostic Use of Circulating Plasma Nucleic Acid Concentrations in Patients with Acute Stroke

Clinical and laboratory factors related to acute isolated vertigo or dizziness and cerebral infarction

Correlation of Brain Biomarker Neuron Specific Enolase (NSE) with Degree of Disability and Neurological Worsening in Cerebrovascular Stroke

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