Neurons in the nucleus tractus solitarius mediate the acupuncture analgesia in visceral pain rats

Liu, Kun; Gao, Xin-Yan; Li, Liang; Ben, Hui; Qin, Qing-Guang; Zhao, Yong; Zhu, Bing

doi:10.1016/j.autneu.2014.08.004

Cited by 23 publications

(14 citation statements)

References 24 publications

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“…Obviously, analgesia induced by different frequencies of EA occurs in distinct neural pathways. Although several investigators have determined the roles of individual cerebral nuclei or areas in EA-induced analgesia (EAA) with classical physical approaches (the stimulation and abolition of certain nerve fibres or nuclei) as well as pharmacological approaches (assessing antagonists and antibodies) [ 6 – 8 ], the neuronal circuitry underlying analgesia induced by different frequencies of EA is not yet clear.…”

Section: Introductionmentioning

confidence: 99%

The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of Electroacupuncture in the Brain

Qiu

Ding

Cui

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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To investigate patterns of c-Fos and c-Jun expression induced by different frequencies of electroacupuncture (EA) in the brain, goats were stimulated by EA of 0, 2, 60, or 100 Hz at a set of “Baihui, Santai, Ergen, and Sanyangluo” points for 30 min. The pain threshold was measured using the potassium iontophoresis method. The levels of c-Fos and c-Jun were determined with Streptavidin-Biotin Complex immunohistochemistry. The results showed that the pain threshold induced by 60 Hz was 82.2% higher (P < 0.01) than that by 0, 2, or 100 Hz (6.5%, 35.2%, or 40.9%). EA induced increased c-Fos and c-Jun expression in most analgesia-related nuclei and areas in the brain. Sixty Hz EA increased more c-Fos or c-Jun expression than 2 Hz or 100 Hz EA in all the measured nuclei and areas except for the nucleus accumbens, the area septalis lateralis, the caudate nucleus, the nucleus amygdala basalis, and the locus coeruleus, in which c-Fos or c-Jun expressions induced by 60 Hz EA did not differ from those by 2 Hz or 100 Hz EA. It was suggested that 60 Hz EA activated more extensive neural circuits in goats, which may contribute to optimal analgesic effects.

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Section: Introductionmentioning

confidence: 99%

The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of Electroacupuncture in the Brain

Qiu

Ding

Cui

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…Specifically, tVNS acts upon the auricular branch of the vagus nerve located medial of the tragus at the entry of the acoustic meatus (Kreuzer et al, 2012). By means of delivery of electric pulses, the stimulation of the auricular branch of the vagus nerve reaches the brain through direct projections to the nucleus of the solitary tract (NST; He et al, 2013;Liu et al, 2014;Nomura & Mizuno, 1984) and the LC (Van Bockstaele, Peoples, & Telegan, 1999). Recent neuroimaging studies confirmed the activation of this brainstem circuitry (NST and LC) following vagal stimulation (Dietrich et al, 2008;Frangos, Ellrich, & Komisaruk, 2015;Kraus et al, 2013).…”

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confidence: 99%

Transcutaneous vagus nerve stimulation (tVNS) enhances conflict-triggered adjustment of cognitive control

Fischer

Ventura‐Bort

Hamm

et al. 2018

Cogn Affect Behav Neurosci

101

103

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Response conflicts play a prominent role in the flexible adaptation of behavior as they represent context-signals that indicate the necessity for the recruitment of cognitive control. Previous studies have highlighted the functional roles of the affectively aversive and arousing quality of the conflict signal in triggering the adaptation process. To further test this potential link with arousal, participants performed a response conflict task in two separate sessions with either transcutaneous vagus nerve stimulation (tVNS), which is assumed to activate the locus coeruleus-noradrenaline (LC-NE) system, or with neutral sham stimulation. In both sessions the N2 and P3 event-related potentials (ERP) were assessed. In line with previous findings, conflict interference, the N2 and P3 amplitude were reduced after conflict. Most importantly, this adaptation to conflict was enhanced under tVNS compared to sham stimulation for conflict interference and the N2 amplitude. No effect of tVNS on the P3 component was found. These findings suggest that tVNS increases behavioral and electrophysiological markers of adaptation to conflict. Results are discussed in the context of the potentially underlying LC-NE and other neuromodulatory (e.g., GABA) systems. The present findings add important pieces to the understanding of the neurophysiological mechanisms of conflict-triggered adjustment of cognitive control.

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“…Research on the mechanism of EA for relieving GI visceral pain found that AP pretreatment markedly reduced c-fos positive neurons and GFAP expression in the NTS in model rats with GI visceral pain; these results suggest that the regulatory process of AP in visceral pain is closely related to the NTS [ 91 ]. Meanwhile, CRD can induce an excitatory response in related neurons in the NTS whereas EA stimulation poses an inhibitory effect on these neurons; these findings provide electrophysiological evidence that the NTS receives the afferent information of CRD-induced visceral pain and participates in the analgesic process of AP [ 92 , 93 ] ( Figure 1 ).…”

Section: Neurological Mechanisms Of Ea For Relieving Gi Visceral Pmentioning

confidence: 99%

Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin

Zhang

Zhao

et al. 2017

Gastroenterology Research and Practice

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It is currently accepted that the neural transduction pathways of gastrointestinal (GI) visceral pain include the peripheral and central pathways. Existing research on the neurological mechanism of electroacupuncture (EA) in the treatment of GI visceral pain has primarily been concerned with the regulation of relevant transduction pathways. The generation of pain involves a series of processes, including energy transduction of stimulatory signals in the sensory nerve endings (signal transduction), subsequent conduction in primary afferent nerve fibers of dorsal root ganglia, and transmission to spinal dorsal horn neurons, the ascending transmission of sensory signals in the central nervous system, and the processing of sensory signals in the cerebral cortex. Numerous peripheral neurotransmitters, neuropeptides, and cytokines participate in the analgesic process of EA in visceral pain. Although EA has excellent efficacy in the treatment of GI visceral pain, the pathogenesis of the disease and the analgesic mechanism of the treatment have not been elucidated. In recent years, research has examined the pathogenesis of GI visceral pain and its influencing factors and has explored the neural transduction pathways of this disease.

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Neurons in the nucleus tractus solitarius mediate the acupuncture analgesia in visceral pain rats

Cited by 23 publications

References 24 publications

The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of Electroacupuncture in the Brain

The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of Electroacupuncture in the Brain

Transcutaneous vagus nerve stimulation (tVNS) enhances conflict-triggered adjustment of cognitive control

Neurobiological Mechanism of Acupuncture for Relieving Visceral Pain of Gastrointestinal Origin

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