Neurons of Intramural Ganglia of the Heart in Its Hyperfunction and Hypertrophy

Меерсон, Ф. З.; Krokhina, E. M.

doi:10.1159/000142754

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…After aortic banding in rabbits and canines, they found that neurons in cardiac ganglia began to enlarge within days, 2 or more months after aortic banding neurons became notably hypertrophied, and 2 years after banding, neurons in cardiac ganglia remained noticeably hypertrophied . Similar to our observations, Meerson and Krokhina reported an edematous and pale appearance to the hypertrophied neurons in hypertrophied hearts . Recently, canines with pacing‐induced heart failure were shown to have increased diameter of parasympathetic nerve bundles in the left atrium .…”

Section: Discussionsupporting

confidence: 88%

“…The only other description of somal hypertrophy of neurons in cardiac ganglia with myocardial hypertrophy, apart from this one, is a qualitative time‐course study by Meerson and Krokhina . After aortic banding in rabbits and canines, they found that neurons in cardiac ganglia began to enlarge within days, 2 or more months after aortic banding neurons became notably hypertrophied, and 2 years after banding, neurons in cardiac ganglia remained noticeably hypertrophied .…”

Section: Discussionmentioning

confidence: 99%

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Hypertrophy of Neurons Within Cardiac Ganglia in Human, Canine, and Rat Heart Failure: The Potential Role of Nerve Growth Factor

Singh

Sayers

Walter

et al. 2013

JAHA

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BackgroundAutonomic imbalances including parasympathetic withdrawal and sympathetic overactivity are cardinal features of heart failure regardless of etiology; however, mechanisms underlying these imbalances remain unknown. Animal model studies of heart and visceral organ hypertrophy predict that nerve growth factor levels should be elevated in heart failure; whether this is so in human heart failure, though, remains unclear. We tested the hypotheses that neurons in cardiac ganglia are hypertrophied in human, canine, and rat heart failure and that nerve growth factor, which we hypothesize is elevated in the failing heart, contributes to this neuronal hypertrophy.Methods and ResultsSomal morphology of neurons from human (579.54±14.34 versus 327.45±9.17 μm2; P<0.01) and canine hearts (767.80±18.37 versus 650.23±9.84 μm2; P<0.01) failing secondary to ischemia and neurons from spontaneously hypertensive rat hearts (327.98±3.15 versus 271.29±2.79 μm2; P<0.01) failing secondary to hypertension reveal significant hypertrophy of neurons in cardiac ganglia compared with controls. Western blot analysis shows that nerve growth factor levels in the explanted, failing human heart are 250% greater than levels in healthy donor hearts. Neurons from cardiac ganglia cultured with nerve growth factor are significantly larger and have greater dendritic arborization than neurons in control cultures.ConclusionsHypertrophied neurons are significantly less excitable than smaller ones; thus, hypertrophy of vagal postganglionic neurons in cardiac ganglia would help to explain the parasympathetic withdrawal that accompanies heart failure. Furthermore, our observations suggest that nerve growth factor, which is elevated in the failing human heart, causes hypertrophy of neurons in cardiac ganglia.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Hypertrophy of Neurons Within Cardiac Ganglia in Human, Canine, and Rat Heart Failure: The Potential Role of Nerve Growth Factor

Singh

Sayers

Walter

et al. 2013

JAHA

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“…It is of interest to note that the marked enlargement of the large argentaffine cells (A-1 and A-2) noted in the present study, along with an increased affinity for silver and a proliferation and hyperplasia of the processes, resemble the phenomena described by Okamoto et al (1964) in ulcerative colitis, by Sti~hr (1984) und Fukuoka (1958 in peptic ulcer, and by Meerson and Krokhina (1965) in cardiac hypertrophy caused by experimental aortic stenosis.…”

Section: Discussionsupporting

confidence: 84%

Myenteric plexus in hypertrophied intestine

Okada

Okamoto

1971

J. Neuro-Viscer. Relat

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SummaryIn six healthy mongrel dogs, hypertrophy of the ileum was induced by experimental stenosis. The number, size and morphological appearance of myenteric ganglion cells in the hypertrophic ileal segments were compared with those in corresponding segments of twelve normal control animals. The following observations are reported. 1. The number of ganglion cells is expressed as N/G, i. e. the mean number of neuronal perikarya identifiable in each myenteric ganglion appearing in a complete, 8 ~t thick transverse section of the ileum. 2. The mean value of N/G in five control animals was found to be 8.94 + 0.064, while in hypertrophied intestines a value of 5.17 -+ 0.062 was obtained, a difference significant at the P < 0.01 leve] of confidence. 8. The mean diameter of neuronal nuclei in six hypertrophied intestines measured 10.07 + 0.154 micra, a value significantly higher than the 8.05 -+ 0.102 micra mean established in twelve controls. Compared with normal material, the distribution curve of nuclear diameters measured in hypertrophic intestines' shows a flattening and a shift to the right. 4. In comparison with normal ganglion cells, most ganglion cells in hypertrophic ilea showed a prominent increase in Nissl substance, 5. In sections impregnated by Jabonero's silver method, evidence was found of an increase in cell-size and in argyrophilia of both argyrophilic and argyrophobic cells in hypertrophied intestines. This phenomenon is particularly pronounced in the larger argentaffine cell groups. The present findings may represent morphological corollaries of changes in the activity level of neurons associated with increased functional demands.

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Eine Cermet‐Glasschmiermittelkombination für Reibpaarungen bei Arbeitstemperaturen von 650–1100°C

Pohl

Verlotski

Schaus

1994

Materialwissenschaft Werkst

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At elevated temperatures, the corrosion and wear resistance and the thermal shock behaviour are as necessary as mechanical stability at high operating temperatures.Metals and ceramics often cannot meet the conditions. Dynamic applications may require lubrication. Ceramics often are not enough resistant to the lubricatings, metals surfaces may be too soft and not very oxidation-resistant. Metal-ceramic materials, -cermets-, use a combination of the properties of their microstructural parts.This paper shows a combination of a cermet and a lubricating glass with interesting aspects for high temperature operation.

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Neurons of Intramural Ganglia of the Heart in Its Hyperfunction and Hypertrophy

Cited by 4 publications

References 4 publications

Hypertrophy of Neurons Within Cardiac Ganglia in Human, Canine, and Rat Heart Failure: The Potential Role of Nerve Growth Factor

Hypertrophy of Neurons Within Cardiac Ganglia in Human, Canine, and Rat Heart Failure: The Potential Role of Nerve Growth Factor

Myenteric plexus in hypertrophied intestine

Eine Cermet‐Glasschmiermittelkombination für Reibpaarungen bei Arbeitstemperaturen von 650–1100°C

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