Neuropad as a diagnostic tool for diabetic autonomic and sensorimotor neuropathy

Spallone, Vincenza; Morganti, Roberto; Siampli, M.; Fedele, T.; D’Amato, Cinzia; Cacciotti, Laura; Maiello, Maria

doi:10.1111/j.1464-5491.2009.02760.x

Cited by 41 publications

(71 citation statements)

References 25 publications

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“…We found high sensitivity and negative predictive value of the Neuropad at 10 min, in concordance with previous studies [13,14,20,21,[28][29][30][31][32]. Although sensitivity and negative predictive value seemed slightly higher in the subgroup with peripheral arterial occlusive disease than without, differences were not significant.…”

Section: Discussionsupporting

confidence: 92%

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Influence of peripheral arterial occlusive disease on the Neuropad^® test performance in patients with diabetes

Aubert

Doeuff

Lajou³

et al. 2013

Diabet. Med.

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Section: Discussionsupporting

confidence: 92%

“…Positive predictive value seemed also generally poorer in our study than in previous works [13,14,20,21,[28][29][30][31][32]; unlike specificity, it was significantly higher in subjects with peripheral arterial occlusive disease than without, which may be explained by the higher prevalence of peripheral neuropathy among these patients.…”

Section: Discussioncontrasting

confidence: 83%

Influence of peripheral arterial occlusive disease on the Neuropad^® test performance in patients with diabetes

Aubert

Doeuff

Lajou³

et al. 2013

Diabet. Med.

View full text Add to dashboard Cite

show abstract

“…Interestingly, NEURO-PAD™ has higher sensitivity and specificity for detecting peripheral neuropathy than milder forms of cardiac autonomic neuropathy using the standardized test proposed by Ewing [44]. This could be due to the fact that NEURO-PAD™ and cardiovascular tests explore different autonomic areas (cardiovascular autonomic neuropathy vs distal autonomic neuropathy) [47]. Spallone et al [47] found that evaluation of the test after 15 min of application provided a better balance between sensitivity (80%) and specificity (61%) in diagnosing both peripheral and autonomic neuropathy.…”

Section: Sudomotor Function Screening Testsmentioning

confidence: 93%

“…This could be due to the fact that NEURO-PAD™ and cardiovascular tests explore different autonomic areas (cardiovascular autonomic neuropathy vs distal autonomic neuropathy) [47]. Spallone et al [47] found that evaluation of the test after 15 min of application provided a better balance between sensitivity (80%) and specificity (61%) in diagnosing both peripheral and autonomic neuropathy.…”

Section: Sudomotor Function Screening Testsmentioning

confidence: 98%

“…NEUROPAD™ testing has been used not only for the diagnosis of peripheral neuropathy but also for detecting autonomic neuropathy [44,47]. Interestingly, NEURO-PAD™ has higher sensitivity and specificity for detecting peripheral neuropathy than milder forms of cardiac autonomic neuropathy using the standardized test proposed by Ewing [44].…”

Section: Sudomotor Function Screening Testsmentioning

confidence: 99%

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Screening for the High-risk Foot of Ulceration: Tests of Somatic and Autonomic Nerve Function

Argiana¹,

Eleftheriadou

Tentolouris

2011

Curr Diab Rep

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Diabetic foot ulcers affect almost 5% of the patients with diabetes and carry a huge physical, emotional, and financial burden. Almost 80% of amputations in patients with diabetes are preceded by a foot ulcer. The need for simple screening methods for prevention of foot ulcers and amputations is indisputable. Simple tests such as monofilament, tuning fork, vibration perception threshold determination, ankle reflexes, and pinprick sensation alone or in combination have been studied prospectively and can be used for identification of patients at risk. Newer tests examining sudomotor dysfunction and skin dryness have been introduced in recent years. In cross-sectional studies sudomotor dysfunction assessed by either sympathetic skin response or NEUROPAD™ (Miro Verbandstoffe GmbH, Wiehl-Drabenderhöhe, Germany) testing has been consistently associated with foot ulceration. In addition, NEUROPAD™ testing is simple, reproducible, and widely available and has a high sensitivity for the diagnosis of clinical or subclinical diabetic polyneuropathy. Prospective studies are required to establish whether sudomotor dysfunction can predict foot ulcers and if simple methods assessing sudomotor dysfunction (eg, NEUROPAD™ testing) can be included in the screening tests for the prevention of this complication.

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Current literature in diabetes

2010

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Neuropad as a diagnostic tool for diabetic autonomic and sensorimotor neuropathy

Abstract: Neuropad is a reliable diagnostic tool for both CAN and DPN, albeit of only moderate accuracy. Extending the observation period to 15 min provides greater diagnostic usefulness.

Cited by 41 publications

References 25 publications

Influence of peripheral arterial occlusive disease on the Neuropad^® test performance in patients with diabetes

Influence of peripheral arterial occlusive disease on the Neuropad^® test performance in patients with diabetes

Screening for the High-risk Foot of Ulceration: Tests of Somatic and Autonomic Nerve Function

Current literature in diabetes

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Neuropad as a diagnostic tool for diabetic autonomic and sensorimotor neuropathy

Abstract: Neuropad is a reliable diagnostic tool for both CAN and DPN, albeit of only moderate accuracy. Extending the observation period to 15 min provides greater diagnostic usefulness.

Cited by 41 publications

References 25 publications

Influence of peripheral arterial occlusive disease on the Neuropad® test performance in patients with diabetes

Influence of peripheral arterial occlusive disease on the Neuropad® test performance in patients with diabetes

Screening for the High-risk Foot of Ulceration: Tests of Somatic and Autonomic Nerve Function

Current literature in diabetes

Contact Info

Product

Resources

About

Influence of peripheral arterial occlusive disease on the Neuropad^® test performance in patients with diabetes

Influence of peripheral arterial occlusive disease on the Neuropad^® test performance in patients with diabetes