2018
DOI: 10.1371/journal.pone.0199165
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Neuropathic-like symptoms and the association with joint-specific function and quality of life in patients with hip and knee osteoarthritis

Abstract: ObjectiveThere is an association between osteoarthritis-related pain severity and function, yet clear evidence about the sole influence of neuropathic-like symptoms on joint function and health-related quality of life (HRQoL) is lacking. Previous studies among knee OA patients show an association between neuropathic-like symptoms, lower functional status and lower quality of life, however analyses were unadjusted or had limited adjustment for influential covariates like pain intensity. The aim of this study wa… Show more

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Cited by 42 publications
(42 citation statements)
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“… 17 It is important to note that a high number of individuals suffering from OA report pain sensations comparable to those described in neuropathies. 3 , 19 …”
Section: Discussionmentioning
confidence: 99%
“… 17 It is important to note that a high number of individuals suffering from OA report pain sensations comparable to those described in neuropathies. 3 , 19 …”
Section: Discussionmentioning
confidence: 99%
“…47 Indeed, although OA pain is believed to be predominantly nociceptive in origin, a population of OA patients (estimates vary greatly between 5% and 65%) can show aspects of neuropathic pain (eg, burning, numbness, and tingling), and the OA population is likely a heterogeneous mix of pain states. 10,86…”
Section: Role Of Nerve Growth Factor In Osteoarthritis Painmentioning
confidence: 99%
“…In knee OA, specifically, this intermittent, sharp pain often arises unpredictably and is associated with giving way or locking of the knee [31]. A minority of people with OA [36,37,38] describe pain qualities, such as burning, shooting, or electric shocks, and more recent evidence shows that some describe perceptual disturbances, including feeling as if their painful limb is altered in size [39,40,41], missing [32,42], or difficult to control [39,42].…”
Section: Introductionmentioning
confidence: 99%