Neuropathic Pain Scale Base Rate for Orofacial Pain Population

Scrivani, Steven J.; Kulich, Ronald J.; Bindayel, Naif A; Chandwani, Brijesh P; Mehta, Noshir R.

doi:10.1016/j.tripleo.2007.02.050

Cited by 1 publication

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“…Though pain rating scales have been evaluated in other neuropathic pain states (postherpetic neuralgia, peripheral diabetic neuropathic pain, chronic regional pain syndrome) [44–46], little data exist relating such scales to neuropathic facial pain. A pilot study evaluating neuropathic facial pain [48] with a pain rating scale showed lower ratings of overall pain intensity and unpleasantness than the present study, though the descriptive qualities of pain were similar (burning, sharp, shooting). These pain ratings are similar to other known nerve injury neuropathic pain states except in the case of overall intensity and unpleasantness.…”

Section: Discussioncontrasting

confidence: 90%

A fMRI Evaluation of Lamotrigine for the Treatment of Trigeminal Neuropathic Pain: Pilot Study

Scrivani¹,

Wallin

Moulton

et al. 2010

Pain Med

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Using functional magnetic resonance imaging (fMRI) methods, we evaluated the effects of lamotrigine vs placebo in a double-blind 1:1 randomized trial. Six patients with neuropathic pain were recruited for the study. All subjects had baseline pain >4/10 on a visual analog scale (VAS) and allodynia to brush as inclusion criteria for the study. Patients underwent two fMRI sessions, with half of the subjects receiving placebo first and half receiving drug first (based on the blinding protocol). Lamotrigine decreased their average pain intensity level from 5.6 to 3.5 on a VAS. All subjects had brush, cold, and heat applied to the affected and mirror-unaffected sides of their face. The results show: 1) in a small cohort, lamotrigine had a significant effect on heat VAS but not on the other stimuli; and 2) contrast analysis of fMRI results for heat stimuli applied to the affected face for lamotrigine vs placebo produced an overall decrease in blood oxygen dependent level signal, suggesting a potential inhibitory effect of the drug on predominantly cortical regions (frontal, parietal, and temporal).

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Section: Discussioncontrasting

confidence: 90%