2012
DOI: 10.1002/ana.23659
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Neuropathologic substrates of Parkinson disease dementia

Abstract: Objective: A study was undertaken to examine the neuropathological substrates of cognitive dysfunction and dementia in Parkinson disease (PD). Methods: One hundred forty patients with a clinical diagnosis of PD and either normal cognition or onset of dementia 2 or more years after motor symptoms (PDD) were studied. Patients with a clinical diagnosis of dementia with Lewy bodies were excluded. Autopsy records of genetic data and semiquantitative scores for the burden of neurofibrillary tangles, senile plaques, … Show more

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Cited by 438 publications
(532 citation statements)
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“…We used primary cells derived from rat embryonic cerebral cortices as a model because they are relatively homogenous (more than 80% neurons) and more readily obtained than dopaminergic neurons. Importantly, cortical neurons are strongly affected in patients with PD (27).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…We used primary cells derived from rat embryonic cerebral cortices as a model because they are relatively homogenous (more than 80% neurons) and more readily obtained than dopaminergic neurons. Importantly, cortical neurons are strongly affected in patients with PD (27).…”
Section: Resultsmentioning
confidence: 99%
“…In the frontal and cingulate cortices, nuclear NFATc4 staining was most prominent in the pyramidal neurons in layers 5 and 6. In DLB, these cortical layers bear the greatest burden of α-syn pathology (27). In the hippocampus, which is also critically involved in PD pathology (47), areas CA3 and CA4 stained more strongly than CA1 or CA2 or the subiculum.…”
Section: Downstream Consequences Of Calcineurin Activation By α-Syn Inmentioning
confidence: 99%
“…The postmortem observation of amyloid-b plaques and tau neurofibrilliary tangles, pathologic hallmarks of Alzheimer disease (AD), in individuals with PD and dementia has led to the hypothesis that the cognitive changes in PD are caused by comorbid AD. [3][4][5] Many patients with PD have substantial cognitive loss without forming plaques and tangles, however, and the severity of neuropsychological deficits in patients with PD with coexisting cortical Lewy body and AD-like pathology correlates only with the former. 6 Whether AD contributes to the cognitive deficits in PD thus remains an unsettled question.…”
mentioning
confidence: 99%
“…Reproduced with permission from [107]. significant correlate of dementia in PD, while AD pathology, being abundant in a subset of patients, may modify the clinical phenotype [154]. On the other hand, up to 50% of AD cases exhibit additional LB pathology, which is associated with a more aggressive disease course and accelerated cognitive dysfunction [155].…”
Section: Diagnostic Criteria For Other Dementiasmentioning
confidence: 99%