Neuropathology associated with exposure to different concentrations and species of mercury: A review of autopsy cases and the literature

O’Donoghue, John L.; Watson, Gene E.; Brewer, Rubell; Zaręba, Grażyna; Eto, Komyo; Takahashi, Hitoshi; Marumoto, Masumi; Love, Tanzy; Harrington, Donald; Myers, Gary J.

doi:10.1016/j.neuro.2020.02.011

Cited by 27 publications

(20 citation statements)

References 37 publications

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“…Reports from the United Nations stated that Hg emissions were increasing in developing countries due to coal-burning and gold mining activities [ 10 ]. Actions on Hg products and waste could have a beneficial impact in minimizing local exposure to Hg, mainly in developing countries and specific populations such as miners, fishermen, and their families [ 14 ].…”

Section: Environmental Impact Of Mercurymentioning

confidence: 99%

“…Several international measures have been taken in recent decades to reduce mercury contamination of the environment and ultimately to prevent noxious consequences for ecosystems and human health [ 14 ]. The Minamata Convention is a global treaty that signs the commitment by governments of more than 140 nations to diminish Hg emissions and usage in order to reduce harm to both humans and the environment [ 10 , 14 , 42 , 43 ]. Nevertheless, it is not clear if the implementation of measures will effectively lead to ecological improvements [ 14 ].…”

Section: Environmental Impact Of Mercurymentioning

confidence: 99%

“…The US Government Agency for Toxic Substances and Disease Registry considers Hg to be the third most toxic substance on the planet [ 9 ]. In the same line, the World Health Organization considers Hg as one of the ten chemicals of major public health concern [ 10 ]. Due to its nature, it can be reduced, but never completely removed or destroyed [ 4 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the same line, the World Health Organization considers Hg as one of the ten chemicals of major public health concern [ 10 ]. Due to its nature, it can be reduced, but never completely removed or destroyed [ 4 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Hg may exist in a variety of forms including elemental Hg (Hg0), inorganic, and organic compounds [ 4 , 8 , 9 , 10 ]. Elemental Hg is liquid at room temperature and is easily converted to vapor and emitted into the atmosphere [ 4 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neuroinflammation

Novo

Martins

Raposo

et al. 2021

IJMS

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Methylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir, MeHg bioaccumulates along the food chain until it is consumed by riverine populations. There has been much interest in the neurotoxicity of MeHg due to recent environmental disasters. Studies have also addressed the implications of long-term MeHg exposure for humans. The central nervous system is particularly susceptible to the deleterious effects of MeHg, as evidenced by clinical symptoms and histopathological changes in poisoned humans. In vitro and in vivo studies have been crucial in deciphering the molecular mechanisms underlying MeHg-induced neurotoxicity. A collection of cellular and molecular alterations including cytokine release, oxidative stress, mitochondrial dysfunction, Ca2+ and glutamate dyshomeostasis, and cell death mechanisms are important consequences of brain cells exposure to MeHg. The purpose of this review is to organize an overview of the mercury cycle and MeHg poisoning events and to summarize data from cellular, animal, and human studies focusing on MeHg effects in neurons and glial cells. This review proposes an up-to-date compendium that will serve as a starting point for further studies and a consultation reference of published studies.

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Section: Environmental Impact Of Mercurymentioning

confidence: 99%