Neuropathy scale score as an independent risk factor for myocardial infarction in patients with type 2 diabetes

Wang, Lian; Guo, Simin; Wang, Weimin; Xu, Biyun; Chen, Wei; Jing, Yali; Jin, Jiewen; Li, Chenxi; Zhou, Yihua; Zhu, Dalong

doi:10.1002/dmrr.3561

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…According to DPN inclusion criteria, they were divided into two groups, the T2DM group (n=18) and the DPN group (n=18). DPN group inclusion criteria: 5 (1) common clinical symptoms, such as pain, numbness, and paresthesia at the end of limbs; (2) the physical examination score of Michigan Neuropathy Screening Instrument (MNSI) 16 is more than five and the score of Toronto Clinical Scoring system (TCSS) is no less than six; 17 (3) electromyography suggests multiple peripheral neuropathies. 18 …”

Section: Methodsmentioning

confidence: 99%

Formate Might Be a Novel Potential Serum Metabolic Biomarker for Type 2 Diabetic Peripheral Neuropathy

Xu,

Xue,

Zhou

et al. 2023

DMSO

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Background As one of the most frequent complications of type 2 diabetes mellitus (T2DM), diabetic peripheral neuropathy (DPN) shows a profound impact on 50% of patients with symptoms of neuropathic pain, numbness and other paresthesia. No valid serum biomarkers for the prediction of DPN have been identified in the clinic so far. This study is to investigate the potential serum biomarkers for DPN firstly based on 1 H-Nuclear Magnetic Resonance ( 1 H-NMR)-based metabolomics technique. Methods Thirty-six patients enrolled in this study were divided into two groups: 18 T2DM patients without DPN (T2DM group) and 18 T2DM patients with DPN (DPN group). Serum metabolites were measured via 1 H-NMR spectroscopy. Bioinformatic approaches including principal component analysis (PCA), orthogonal partial least squares-discriminant analysis (OPLS-DA), independent sample t -test, Fisher’s test, Pearson and Spearman correlation analysis, Stepwise multiple linear regression analysis and receiver operating characteristic (ROC) curve analysis were used to identify the potential altered serum biomarkers. Results A total of 20 metabolites were obtained and further analyzed. Formate was identified as the only potential biomarker that decreased in the DPN group with statistical significance after multiple comparisons (p<0.05). Formate also displayed a negative relationship with some elevated clinical markers in DPN. ROC curve analysis showed a good discriminative ability for formate in DPN with an area under the curve (AUC) value of 0.981. Conclusion Formate could be considered a potential serum metabolic biomarker for DPN. The reduced level of formate in DPN may be associated with mitochondrial dysfunction and gut microbiota alteration. Monitoring the level of serum formate would be an important strategy for the early diagnosis of DPN and a supplement of formate may be a promising treatment for DPN in the future.

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Section: Methodsmentioning

confidence: 99%

Formate Might Be a Novel Potential Serum Metabolic Biomarker for Type 2 Diabetic Peripheral Neuropathy

Xu,

Xue,

Zhou

et al. 2023

DMSO

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“…However, these correlations have not been explored in Hungarian patients with diabetes until now. Diabetic neuropathy and the risk of cardiovascular disease are associated with an increase in all-cause mortality [ 17 ]. A retrospective cohort study in Hungary has already shown the association of DSPN with all-cause mortality [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Correlations between distal sensorimotor polyneuropathy and cardiovascular complications in diabetic patients in the North-Eastern region of Hungary

Pető,

Tóth,

Hernyák

et al. 2024

PLoS ONE

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Distal sensorimotor polyneuropathy (DSPN) is the earliest detectable and the most frequent microvascular complication in diabetes mellitus. Several studies have previously demonstrated correlations between cardiovascular risk factors in diabetic patients and independent risk factors for diabetic neuropathy. Our objective was to retrospectively analyze data from diabetic patients in the North-East region of Hungary who underwent neuropathy screening at the Diabetic Neuropathy Center, University of Debrecen, between 2017 and 2021. We aimed to investigate the correlations between cardiovascular risk factors and microvascular complications among patients with DSPN. The median age of the patients was 67 years, 59,6% were female, and 91,1% had type 2 diabetes. The prevalence of DSPN among the study subjects was 71.7%. A significantly longer duration of diabetes (p<0.01) was noted in patients with DSPN. Those with DSPN demonstrated a significantly higher HbA1c level (p<0.001) and a greater frequency of insulin use (p = 0.001). We observed a significantly elevated albumin/creatinine ratio (p<0.001) and a significantly lower eGFR (p<0.001) in patients with DSPN. Diabetic retinopathy exhibited a significantly higher prevalence in patients with DSPN (p<0.001). A higher prevalence of myocardial infarction (p<0.05), ischemic heart disease (p<0.001), peripheral arterial disease (p<0.05) and a history of atherosclerosis (p<0.05) was observed in patients with DSPN. In a multivariate logistic regression analysis, the following factors were independently associated with the presence of DSPN: higher HbA1c (OR:2.58, 95% CI:1.89–3.52, p<0.001), age (OR:1.03, 95% CI:1.01–1.05, p = 0.006), albumin/creatinine ratio above 3 mg/mmol (OR:1.23, 95% CI:1.06–1.45, p = 0.008), retinopathy (OR:6.06, 95% CI:1.33–27.53, p = 0.02), and composite cardiovascular endpoint (OR:1.95, 95% CI:1.19–3.19, p = 0.008). Our study revealed that age, elevated HbA1c levels, significant albuminuria, retinopathy, and cardiovascular complications may increase the risk of DSPN. Further investigation of these associations is necessary to understand the impact of patient characteristics during the treatment of diabetic neuropathy.

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Morbidity and mortality of patients with diabetic neuropathy treated with pathogenetically oriented alpha-lipoic acid versus symptomatic pharmacotherapies – A nationwide database analysis from Hungary

Jermendy¹,

Rokszin²,

Fábián³

et al. 2023

Diabetes Research and Clinical Practice

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Neuropathy scale score as an independent risk factor for myocardial infarction in patients with type 2 diabetes

Cited by 5 publications

References 36 publications

Formate Might Be a Novel Potential Serum Metabolic Biomarker for Type 2 Diabetic Peripheral Neuropathy

Formate Might Be a Novel Potential Serum Metabolic Biomarker for Type 2 Diabetic Peripheral Neuropathy

Correlations between distal sensorimotor polyneuropathy and cardiovascular complications in diabetic patients in the North-Eastern region of Hungary

Morbidity and mortality of patients with diabetic neuropathy treated with pathogenetically oriented alpha-lipoic acid versus symptomatic pharmacotherapies – A nationwide database analysis from Hungary

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