Neuropeptide and Kinin Antagonists

Hill, Ray; Oliver, Kevin R.

doi:10.1007/978-3-540-33823-9_7

Cited by 22 publications

(16 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Peripherally, NGF directly activates and sensitizes primary afferent nociceptors (56). Our results demonstrate the presence of TrkA on CGRP-positive sensory fibers, which are likely to be C-or A␦-fiber nociceptors (33). Together, with the increase in NGF in the cysts during proestrus when hyperalgesia severity is greatest, these findings suggest that NGF directly activates C-fibers in cysts, thereby contributing to ENDO-induced hyperalgesia.…”

Section: Multiple Potential Roles For Ngf/trka Signaling In Endometrimentioning

confidence: 55%

Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat

Zhang

Dmitrieva²,

Liu³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Endometriosis is a poorly understood, estradiol-dependent condition associated with severe pelvic pains and defined by vascularized endometrial growths outside the uterus. Endometriosis is produced in cycling rats by autotransplanting pieces of uterus onto abdominal arteries where they develop into cysts. The surgery induces vaginal and abdominal muscle hyperalgesia, whose severity is greatest in proestrus and nearly absent in estrus. The cysts contain growth factors and cytokines and develop their own sympathetic and sensory C-and A␦-fiber innervation. Here, we used quantitative immunostaining and protein array analyses to test the hypothesis that the innervation and growth factor/cytokine content of the cysts, but not uterine horn, contribute to proestrous-to-estrous changes in hyperalgesic severity. If so, these characteristics in the cysts, but not the uterine horn, should change with estrous stage. In cysts, the density of sympathetic (but not sensory) neurites and amounts of NGF and VEGF proteins (but not cytokines IL-1, IL-6, IL-10, or TNF-␣) were greater in proestrus than estrus. These changes were accompanied by vascular changes. Both sympathetic and sensory fibers in both stages colabeled with TrkA, indicating that changes in NGF could act on both afferent and efferent fibers. In contrast with the cysts, no changes occurred in the uterine horn between proestrus and estrus. Together, these results suggest that coordinated proestrous-to-estrous changes in innervation and vascularization of the cysts contribute to similar changes in hyperalgesic severity. The findings also encourage consideration of endometriosis as a neurovascular condition.

show abstract

Section: Multiple Potential Roles For Ngf/trka Signaling In Endometrimentioning

confidence: 55%

Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat

Zhang

Dmitrieva²,

Liu³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…The prediction that NK1 receptor antagonists would be effective analgesics was supported by a large body of preclinical data (reviewed by Hill and Oliver, 2006). Although CP-99,994 was efficacious in a model of acute third molar extraction (Dionne et al, 1998), subsequent trials of several NK1 receptor antagonists could demonstrate no efficacy against long-standing pain of osteoarthritis, diabetic neuropathy or migraine (Rupniak and Kramer, 1999; Goldstein et al, 2000; Goldstein et al, 2001a; Goldstein et al, 2001b; Sindrup et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception

2010

View full text Add to dashboard Cite

The rostral ventromedial medulla (RVM), a central relay in the bulbospinal pathways that modulate nociception, contains high concentrations of Substance P (Sub P) and neurokinin-1 (NK1) receptors. However, the function of Sub P in the RVM is poorly understood. This study characterized the actions of Sub P in the RVM in the absence of injury and then used two NK1 receptor antagonists, L-733,060 and L-703, 606, to probe the role of endogenously released Sub P in the development and maintenance of persistent inflammatory nociception of immune or neurogenic origin. In uninjured rats, microinjection of Sub P in the RVM produced a transient thermal antinociception that was attenuated by pretreatment with L-733,060 or L-703,606. It did not alter threshold to withdrawal from tactile stimulation with von Frey filaments. Microinjection of the antagonists alone did not alter paw withdrawal latency or threshold suggesting that Sub P is not tonically released in the RVM in the absence of injury. However, microinjection of either antagonist in the RVM was sufficient to reverse heat hyperalgesia 4 h, 4 days or 2 weeks after intraplantar injection of complete Freund’s adjuvant (CFA). Antagonism of NK1 receptors in the RVM did not prevent or reverse tactile hypersensitivity induced by CFA, but did attenuate that produced by capsaicin. NK1 receptor antagonism did not prevent the development of thermal hyperalgesia, tactile hypersensitivity or spontaneous pain behaviors induced by mustard oil. The results suggest that Sub P has bimodal actions in the RVM and that following inflammatory injury, it can play a critical role as a pronociceptive agent in the development and maintenance of hyperalgesia and tactile hypersensitivity. However, its actions are highly dependent on the stimulus modality and the type of injury, and this may be an additional basis for the poor efficacy of NK1 receptor antagonists in clinical trials.

show abstract

“…Neuropeptide regulation of male turning behavior Neuropeptides are important neural regulators of many complex animal behaviors such as sleep, feeding, nociception, reproduction, and social behaviors (Storm and Tecott, 2005;Borgland et al, 2006;Sabatier, 2006;Saper, 2006;Hill and Oliver, 2007). FMRFamide-like neuropeptides constitute a major family of C. elegans neuropeptides (Li et al, 1999;Kim and Li, 2004 The relationship between peptidergic and classical neurotransmitter signaling is an interesting topic.…”

Section: Discussionmentioning

confidence: 99%

“…Neuropeptides modulate many complex animal behaviors, including feeding, nociception, circadian rhythm, reproduction, learning, and social behaviors (Storm and Tecott, 2005;Borgland et al, 2006;Sabatier, 2006;Saper, 2006;Hill and Oliver, 2007). The C. elegans genome contains at least 30 FMRFamide-like neuropeptide ( flp) genes that are predicted to encode over 70 biologically active FMRF-amide like neuropeptides (FLPs) (Li, 2005) (S. Husson and L. Schoofs, personal communication).…”

Section: Introductionmentioning

confidence: 99%

FMRFamide-Like Neuropeptides and Mechanosensory Touch Receptor Neurons Regulate Male Sexual Turning Behavior inCaenorhabditis elegans

Liu¹,

Kim²,

Li³

et al. 2007

J. Neurosci.

View full text Add to dashboard Cite

Neuropeptide and Kinin Antagonists

Cited by 22 publications

References 217 publications

Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat

Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts in the rat

Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception

FMRFamide-Like Neuropeptides and Mechanosensory Touch Receptor Neurons Regulate Male Sexual Turning Behavior inCaenorhabditis elegans

Contact Info

Product

Resources

About