Neuropeptide FLFQPQRFamide receptors within the ventral mesenchephalon and dopaminergic terminal areas: Localization and functional antiopioid involvement

Marco, N.; Stinus, Luis; Allard, Michèle; Moal, Michel Le; Simonnet, Guy

doi:10.1016/0306-4522(94)00383-g

Cited by 37 publications

(15 citation statements)

References 38 publications

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“…The inability to observe NPFF1 binding sites might be explained by limitations of detection of the autoradiographic technique or possibly that NPFF1 receptors are expressed on terminal projections of spinal cord neurons outside of the spinal cord. The localization of mRNA and binding sites for NPFF1 and NPFF2 in various components of the basal ganglia, such as the nucleus accumbens, substantia nigra, and the caudate putamen, suggests that NPFF receptors might play an in the regulation of the central dopaminergic system, albeit and indirect one, because previous studies have shown that NPFF binding sites are not found in dopaminergic cell bodies (36). Some of the highest levels of NPFF-like immunoreactivity have been observed in the rat hypothalamus (3,37).…”

Section: Localization Of Npff1 and Npff2 Mrna In Human Andmentioning

confidence: 99%

Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF

Bonini

Jones

Adham

et al. 2000

Journal of Biological Chemistry

405

433

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The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from human and rat central nervous system tissues. NPFF specifically bound to NPFF1 (K d ‫؍‬ 1.13 nM) and NPFF2 (K d ‫؍‬ 0.37 nM), and both receptors were activated by NPFF in a variety of heterologous expression systems. The localization of mRNA and binding sites of these receptors in the dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei supports a role for NPFF in pain modulation. Among the receptors with the highest amino acid sequence homology to NPFF1 and NPFF2 are members of the orexin, NPY, and cholecystokinin families, which have been implicated in feeding. These similarities together with the finding that BIBP3226, an anorexigenic Y1 receptor ligand, also binds to NPFF1 suggest a potential role for NPFF1 in feeding. The identification of NPFF1 and NPFF2 will help delineate their roles in these and other physiological functions.

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Section: Localization Of Npff1 and Npff2 Mrna In Human Andmentioning

confidence: 99%

Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF

Bonini

Jones

Adham

et al. 2000

Journal of Biological Chemistry

405

433

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“…The original tetrapeptide plays a variety of roles in mammals, e.g., influence on cardiovascular functions [Mues et al, 1982;Wong et al, 1985;Roth et al, 1987], modulation of opioid activity in the brain and spinal neurons [Gayton, 1982;Guzman et al, 1989;Allard et al, 1991Allard et al, , 1994Aarnisalo and Panula, 1995;Devillers et al, l995;Dupouy and Zajac, 1995;Marco et al, 1995;Gouarderes et al, 1996;Panula et al, 1996], and stimulation of grooming behavior [Gayton, 1982]. Peptides belonging to FMRFamide family are easily visualized in the nervous system by using antibodies raised against the tetrapeptide.…”

Section: Introductionmentioning

confidence: 99%

Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

D’Aniello¹,

Fiorentin²,

Pinelli³

et al. 2001

Brain Behav Evol

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Neuroanatomical distribution of FMRFamide-like immunoreactivity was investigated in the brain and olfactory system of the viviparous skink, Chalcides chalcides. In the adult brain FMRFamide immunoreactive (ir) perikarya were observed in the diagonal band of Broca, medial septal nucleus, accumbens nucleus, bed nucleus of the anterior commissure, periventricular hypothalamic nucleus, lateral forebrain bundle, and lateral preoptic, subcommissural, suprachiasmatic and lateral hypothalamic areas. This pattern was seen in both male and female brains. Though all major brain areas showed FMRFamide-ir innervation, the densest ir fiber network was observed in the hypothalamus. During development, ir elements were observed for the first time in embryos at mid-pregnancy. FMRFamide perikarya were located along the ventral surface of the vomeronasal nerve, in the olfactory peduncle mediobasally, as well as in the anterior olfactory nucleus and olfactory tubercle. Furthermore, some ir neurons were observed in the rhombencephalic reticular substance; however, the ir fiber network was poorly developed. Later in development FMRFamide-ir neurons appeared also in the bed nucleus of the anterior commissure as well as the rhombencephalic nucleus of solitary tract and the dorsal motor nucleus of vagus nerve. In juveniles, the distribution profile of FMRFamide immunoreactivity was substantially similar to that of the adults, with a less widespread neuronal distribution and a more developed fiber network. Ontogenetic presence of FMRFamide immunoreactivity in the nasal area has been linked to the presence of a nervus terminalis in this reptile.

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“…One of the major brain loci involved in this process is the ventral tegmental area (VTA), where opioids remove the GABAergic inhibition exerted on dopaminergic neurons projecting to corticolimbic areas, leading to an increase in locomotor activity. In the VTA, NPFF receptors have been detected on non-dopaminergic neurons [104]. Co-injected in this area with morphine, NPFF, which is inactive by itself with respect to locomotor behavior, suppresses the morphine-induced hyperactivity [104].…”

Section: Locomotor Activitymentioning

confidence: 99%

“…In the VTA, NPFF receptors have been detected on non-dopaminergic neurons [104]. Co-injected in this area with morphine, NPFF, which is inactive by itself with respect to locomotor behavior, suppresses the morphine-induced hyperactivity [104]. In addition, NPFF abolishes the exploratory behavior mediated by endogenous opioid activity (naloxone reversible) in response to a novel but not a familiar environment [105].…”

Section: Locomotor Activitymentioning

confidence: 99%

“…In contrast, the aversive or mu-opposing effects of dynorphin are thought to be mediated by a direct presynaptic inhibition of dopamine release in the nucleus accumbens [96]. NPFF receptors have been detected on non-dopaminergic cells in the VTA [104], and their activation suppressed morphineinduced hyperactivity [104].…”

Section: Cellular Mechanisms Underlying the Action Of Opioid Modulatimentioning

confidence: 99%

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Opioid-modulating Peptides: Mechanisms of Action

Mollereau¹,

Roumy²,

Zajac

2005

CTMC

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Opioids are involved in the physiological control of numerous functions of the central nervous system, particularly nociception. It appears that some endogenous neuropeptides, called anti-opioids, participate in an homeostatic system tending to reduce the effects of opioids. Neuropeptide FF (NPFF) and cholecystokinin (CCK) possess these properties and, paradoxically, the opioid peptides nociceptin and dynorphin display some anti-opioid activity. All these peptides exhibit complex properties as they are able to both counteract and potentiate opioid activity, acting rather as modulators of opioid functions. The purpose of this review is to highlight that two different mechanisms are clearly involved in the control of opioid functions by opioid-modulating peptides: a circuitry-induced mechanism for nociceptin and dynorphin, and a cellular anti-opioid mechanism for NPFF and CCK. The knowledge of these mechanisms has potential therapeutic interest in the control of opioid functions, notably for alleviating pain and/or for the treatment of opioid abuse.

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Neuropeptide FLFQPQRFamide receptors within the ventral mesenchephalon and dopaminergic terminal areas: Localization and functional antiopioid involvement

Cited by 37 publications

References 38 publications

Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF

Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF

Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

Opioid-modulating Peptides: Mechanisms of Action

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