2018
DOI: 10.1093/ndt/gfx351
|View full text |Cite
|
Sign up to set email alerts
|

Neuropeptide Y and chronic kidney disease progression: a cohort study

Abstract: NPY associates with proteinuria and faster CKD progression as well as with a higher risk of kidney failure. These findings suggest that the sympathetic system and/or properties intrinsic to the NPY molecule may play a role in CKD progression.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
21
2

Year Published

2018
2018
2023
2023

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 19 publications
(25 citation statements)
references
References 51 publications
2
21
2
Order By: Relevance
“…We have observed increased NPY in hypertensive patients. Previously, NPY was reported to be associated with cardiovascular disease and cardiovascular risk factors [30,31,33,34,36]. However, we did not see any difference in NPY concentrations among patients with and without cardiovascular disease, which might be explained by low number of subjects in cardiovascular disease group (n = 21).…”
Section: Discussioncontrasting
confidence: 83%
See 2 more Smart Citations
“…We have observed increased NPY in hypertensive patients. Previously, NPY was reported to be associated with cardiovascular disease and cardiovascular risk factors [30,31,33,34,36]. However, we did not see any difference in NPY concentrations among patients with and without cardiovascular disease, which might be explained by low number of subjects in cardiovascular disease group (n = 21).…”
Section: Discussioncontrasting
confidence: 83%
“…Next, we observed increased serum concentration of NPY in samples of patients with diabetic nephropathy in our study. Data about NPY as a contributor to diabetic complications, kidney disease [30] and nephropathy in type 2 diabetes [32] have emerged recently. Moreover, association of polymorphism of NPY gene have been linked to increased risk of diabetic nephropathy in type 2 diabetes [34].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These data confirmed the direct role of sympathetic nerves in regulating kidney function in the context of hypertension. Sympathetic nerve activity (measured via neurotransmitters norepinephrine and neuropeptide Y) was found elevated during kidney diseases progression in patients and preclinical models and associated with decline in GFR [ 56 , 57 , 58 ]. Increased kidney sympathetic activity could be prevented by elevating circulating NO.…”
Section: Impact Of the Impaired No/sgc/cgmp Signaling On Kidney Fumentioning
confidence: 99%
“…Analysis of patient cohorts also revealed a significant reduction in glomerular NPY expression in both early and late-stage diabetic nephropathy (DN), as well as in several other human albuminuric conditions. This contrasts with the increased plasma and urinary levels of NPY that are observed in diabetes and CKD (19)(20)(21)(22). This prompted us to further investigate the potential role of NPY (and NPY signaling) in the podocyte and glomerulus.…”
mentioning
confidence: 98%