Neuropeptide Y expression in cutaneous melanoma

Gilaberte, Yolanda; Roca, María J.; García-Prats, María Dolores; Coscojuela, C.; Arbues, M. Dolores; Vera-Alvarez, J

doi:10.1016/j.jaad.2011.02.015

Cited by 19 publications

(23 citation statements)

References 35 publications

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“…37 The elevated levels of NPY receptor have been found in breast cancer, neuroendocrine tumors, kidney cancer, prostate cancer, and some types of sarcomas. 38 Until now, SubP and NPY have not studied as biomarkers for AMI, so we validated two biomarker candidates using human serum samples of the AMI patient by analysis of the ELISA method.…”

Section: Resultsmentioning

confidence: 99%

Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients

Han¹,

Seo²,

Jung³

et al. 2014

Bulletin of the Korean Chemical Society

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Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients' sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients' sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.

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Section: Resultsmentioning

confidence: 99%

Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients

Han¹,

Seo²,

Jung³

et al. 2014

Bulletin of the Korean Chemical Society

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“…NPY is highly expressed in melanoma, and its expression exhibits an association with vertical growth and presence of metastasis [48]. The NPY is highly expressed in atopic skin -a stress-related condition -together with the NGF which has been also associated with psychological stress [49].…”

Section: Neuropeptide Y (Npy)mentioning

confidence: 99%

Neuropeptides and skin aging

Elewa¹,

Makrantonaki²,

Zouboulis

2013

Hormone Molecular Biology and Clinical Investigation

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Neuropeptides (NP) are peptides that are released as chemical messengers from nerve cells. They act either in an endocrine manner, where they reach their target cells via the bloodstream or a paracrine manner, as co-transmitters modulating the function of neurotransmitters. To date approximately 100 different NP have been described in the literature. In recent years, several studies have documented that human skin expresses several functional receptors for NP, such as corticotropin-releasing hormone, melanocortins, β-endorphin, vasoactive intestinal polypeptide, neuropeptide Y and calcitonin gene-related peptide. These receptors modulate the production of inflammatory cytokines, proliferation, differentiation, lipogenesis and hormone metabolism in human skin cells. In addition, several NP are directly produced by human skin cells, indicating the complexity of understanding the real functions of NPs in human skin. In this review we address the possible effects of neuropeptides on the pathogenesis of aged skin.

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“…including neuroblastoma, [52] breast cancer, [53] pancreatic ductal adenocarcinoma, [54] and colon cancer. [55,56] Inflammation (inflammatory bowel disease)-induced nuclear factor-kappa B (NF-B) activation up-regulates the level of netrin-1, which is reported to be not only involved in colorectal tumor promotion and progression but also associated with worse outcome in poorly differentiated pancreatic adenocarcinoma. [57][58][59] Surprisingly, netrin-1 also plays a key role in improving pancreatic and pulmonary injury and possesses anti-inflammatory capability by inhibiting leukocyte infiltration in mice with severe acute pancreatitis, which may provide important clues for identifying novel treatment targets for pancreatitis and even pancreatic cancer.…”

Section: Introductionmentioning

confidence: 99%

“…NPY receptors including Y1, Y2, and Y5 are expressed in various types of cancers, such as pancreatic, breast, ovarian cancers, and neuroblastoma. [64][65][66][67] The actions of NPY/NPY receptors in cancer progression are dependent on cancer type or receptor type. Y1 receptor is predominantly expressed in human breast cancer, while Y2 receptor is preferentially expressed in normal human breast cells.…”

Section: Introductionmentioning

confidence: 99%

“…[26] By immunohistochemistry staining, NPY was found to be closely correlated with the progression of cutaneous melanoma, whose expression is significantly higher in the clinical melanoma specimens, especially the nodular type, and is associated with invasiveness independent of proliferative markers such as thickness, ulceration, and mitotic index. [55] NOREPINEPHRINE NE functions not only as a neurotransmitter when it is released from noradrenergic neurons in the locus coeruleus, but also as a hormone when released from the adrenal medulla into the blood. NE is synthesized from dopamine by dopamine -hydroxylase in the secretory granules of the medullary chromaffin cells.…”

Section: Introductionmentioning

confidence: 99%

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The role of neural-related factors in the metastasis of the gastrointestinal cancer

Song

2013

J Can Res Ther

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Neurotransmitters are identified to be endogenous chemicals and act on neurons to transmit signals to each other or to a target cell across synapse. They are involved in many brain functions including analgesia, reward, food intake, metabolism, reproduction, social behaviors, learning, and memory. Recently, sympathetic nerve fibers were detected in many solid tumors including gastrointestinal cancer, supporting the idea that neural system has effects on tumor progression. Neurotransmitters were secreted from the sympathetic nerve fibers and subsequently infiltrated into tumor tissues. Further studies disclosed the different mechanisms of various kinds of neurotransmitters in the progression of carcinogenesis, including tumor cell proliferation, angiogenesis, and tumor invasion and metastasis. Neurotransmitters are mainly subdivided into four types, amino acids, monoamines, peptides, and others, each of which contains multiple chemicals. For this reason, we cannot describe each in detail. In this review, we will focus on several important neurotransmitters including tachykinis, neuropeptide Y, and b-adrenergic receptors. How they function and their crosstalks with the immune system in the progression, especially the metastasis of gastrointestinal cancer, will be described. Finally, we will summarize the clinical implications in the treatment of gastrointestinal cancer.

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Neuropeptide Y expression in cutaneous melanoma

Cited by 19 publications

References 35 publications

Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients

Substance P and Neuropeptide Y as Potential Biomarkers for Diagnosis of Acute Myocardial Infarction in Korean Patients

Neuropeptides and skin aging

The role of neural-related factors in the metastasis of the gastrointestinal cancer

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