Neuropeptide Y (NPY)-like immunoactive nerve fibers in the human and monkey (Macaca fascicularis) kidney

Norvell, John E.; MacBride, Robert G.

doi:10.1016/0304-3940(89)90012-8

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…Immunohistochemical techniques detect NPY in the kidney of various species including rat [9,27,56,98], mouse [9], hamster [9], guinea pig [9,98], pig [98], dog [98], monkey [9,82] and man [9,51,82]. NPY is found in almost all renal sympathetic neurons [27,56].…”

Section: Presence and Release Of Npy In The Kidneymentioning

confidence: 99%

Renal effects of neuropeptide Y

Bischoff¹,

Michel²

1998

Pfl�gers Archiv European Journal of Physiology

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Neuropeptide Y (NPY) is a co-transmitter of the sympathetic nervous system including the renal nerves. The kidney expresses NPY receptors, which can also be activated by peptide YY (PYY), a circulating hormone released from gastrointestinal cells. Five subtypes of NPY receptors have been cloned, among which Y1, Y2 and Y5 appear to be involved in the regulation of renal function. NPY produces potent renal vasoconstriction in vitro in isolated interlobar arteries and in the isolated perfused kidney and in vivo upon intrarenal or systemic administration via a Y1 receptor. Nevertheless glomerular filtration rate is altered only little if at all by NPY, indicating a greater effect on the vas efferens than the vas afferens. NPY can inhibit renin release via Y1-like receptors. NPY can stimulate Na+/K+ adenosine triphosphatase (Na+/K+-ATPase) in proximal tubules via Y2 receptors and can antagonize the effects of vasopressin on isolated collecting ducts. It can also act prejunctionally to inhibit noradrenaline release via Y2 receptors. Despite the profound reductions of renal blood flow, systemic NPY infusion can cause diuresis and natriuresis; this is largely independent of pressure natriuresis mechanisms and is possibly mediated by an extrarenal Y5 receptor. Studies with the converting enzyme inhibitor ramiprilat and the bradykinin receptor antagonist icatibant indicate that bradykinin mediates, at least partly, diuretic NPY effects. NPY antagonists enhance basal renal blood flow but do not alter basal diuresis or natriuresis indicating that renovascular, but not tubular, NPY receptors may be tonically activated by endogenous NPY.

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Section: Presence and Release Of Npy In The Kidneymentioning

confidence: 99%

Renal effects of neuropeptide Y

Bischoff¹,

Michel²

1998

Pfl�gers Archiv European Journal of Physiology

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“…However, in a subset of RCCs and nephroblastomas, a dense network of nerve fibers reactive for NPY was found, presumably originating from preexisting NPY-containing renal nerves. 7 This is an unexpected finding since, to our knowledge, nerve fibers within RCC have not been described previously using other immunohistochemical neural markers. 32 In general, nerve fibers have been rarely observed in human tumors.…”

Section: Discussionmentioning

confidence: 62%

“…Staining was carried out with DAB and counterstaining, with hemalum. Nerve fibers in the adjacent renal parenchyma served as the positive internal control 7 and adrenal medulla, as the positive external control for NPY immunohistochemistry. 25 Colonic mucosa was used as a positive control for PYY and PP immunohistochemistry.…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Among many other sites, NPY has been localized to perivascular nerves in the human kidney. 7 NPY receptors may also play a role in human neoplasia. High incidence rates of subtypes Y1 and Y2 were found in tumors related to steroid hormone metabolism (adrenal cortical tumors, ovarian sex cord-stromal tumors, breast carcinomas), 8,9 in neuroendocrine tumors (pheochromocytomas and paragangliomas) 10 and in embryonal tumors (neuroblastomas).…”

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confidence: 99%

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Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas

Körner

Waser

Reubi

2005

Intl Journal of Cancer

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Numerous peptide receptors are overexpressed in human cancer, permitting in vivo tumor targeting. Among such receptors, those for the neurotransmitter neuropeptide Y (NPY) are overexpressed in various tumors. Since NPY can play a role in the kidney, NPY receptor expression and/or endogenous production of peptides of the NPY family (NPY, PYY, PP) were evaluated in 40 renal cell carcinomas (RCCs) and 18 nephroblastomas. NPY receptor protein expression was investigated by in vitro autoradiography using 125 I-labeled PYY in competition with NPY receptor subtype-selective analogs. NPY, PYY and PP production was assessed immunohistochemically. Fifty-six percent of RCCs expressed the Y1 receptor subtype in moderate density, and 80% of nephroblastomas expressed Y1 and Y2 subtypes in moderate to high density. Y1 was also highly expressed in intratumoral blood vessels. In selected cases, NPY was observed in nerve fibers in close association with intratumoral blood vessels and in the vicinity of tumor cells, while no PYY or PP was detected immunohistochemically in these sites. NPY receptors on renal tumor cells and tumor blood vessels may therefore be the molecular targets of endogenous NPY released by intratumoral nerve fibers. With regard to clinical applications, NPY receptors may act as in vivo targets for receptor-directed therapy of RCCs and nephroblastomas for which alternative therapeutic approaches are still required. ' 2005 Wiley-Liss, Inc.Key words: NPY receptor; renal cell carcinoma; nephroblastoma; receptor autoradiography Peptide hormone receptors are overexpressed in a wide variety of human tumors.1 Like other cell surface molecules, these receptors become increasingly important for clinical applications. In particular, they allow receptor-targeted tumor imaging and therapy with corresponding peptide hormone analogs. For instance, scintigraphy using the somatostatin analog Octreoscan is highly sensitive at detecting gastroenteropancreatic neuroendocrine tumors which express somatostatin receptors in high amounts.2,3 Moreover, targeted radiotherapy of these tumors with 90 Y-or 177 Lu-labeled somatostatin analogs is also promising. 4,5 Another peptide hormone receptor family with a potential future role in this field is the NPY receptor family. It belongs to the G protein-coupled receptor superfamily and comprises various subtypes. Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. 6 They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter NPY and the 2 hormones PYY and PP. Among many other sites, NPY has been localized to perivascular nerves in the human kidney. 7 NPY receptors may also play a role in human neoplasia. High incidence rates of subtypes Y1 and Y2 were found in tumors related to steroid hormone metabolism (adrenal cortical tumors, ovarian sex cord-stromal tumors, breast carcinomas), 8,9 in neuroendocrine tumors (pheochromocytomas and paragangliomas) 10

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“…Since then, numerous studies have confirmed the presence of the peptide in the kidney of man, rat, monkey, mouse, hamster and guinea pig [11][12][13][14]. The peptide has been localized to adrenergic nerve endings in all segments of the renal arterial system [15,16], including the juxtamedullary regions, and afferent and efferent arterioles at the vascular pole of the glomeruli [14].…”

Section: Npy Localization In the Kidneymentioning

confidence: 91%

Role of neuropeptide Y in the regulation of kidney function

Winaver

Abassi

Experientia Supplementum

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Neuropeptide Y (NPY)-like immunoactive nerve fibers in the human and monkey (Macaca fascicularis) kidney

Cited by 10 publications

References 13 publications

Renal effects of neuropeptide Y

Renal effects of neuropeptide Y

Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas

Role of neuropeptide Y in the regulation of kidney function

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