Role of neuropeptide Y in the regulation of kidney function

Winaver, Joseph; Abassi, Zaid

doi:10.1007/3-7643-7417-9_9

Cited by 12 publications

(13 citation statements)

References 62 publications

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“…Our study demonstrated that greater CKD severity was associated with progressively higher serum NpY levels and lower CSF NpY levels, which is consistent with previous studies. 13,25,26 However, the role of NpY in CKD progression has not been completely elucidated. Recent studies have primarily focused on the relationship between NpY and the physiological regulation of renal haemodynamics or electrolyte excretion, and they have rarely related NpY to metabolic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have primarily focused on the relationship between NpY and the physiological regulation of renal haemodynamics or electrolyte excretion, and they have rarely related NpY to metabolic abnormalities. 25,26 Neuropeptide signalling pathways, which regulate appetite and energy expenditure, affect the expression of key proteins associated with muscle mass maintenance. 27,28 NpY is an important factor in the neuropeptide signalling pathways that affect the appetite regulation.…”

Section: Discussionmentioning

confidence: 99%

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Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease

Fang

et al. 2015

Eur J Clin Nutr

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease

Fang

et al. 2015

Eur J Clin Nutr

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“…In addition, no effect of NPY was observed on renin release from renal cortical slices (798). Furthermore, no renal phenotype has been reported in mouse models deficient in NPY or in Y 1 receptors (953), although the administration of NPY has been found to decrease the renal blood flow and to induce diuresis and natriuresis (78).…”

Section: Neuropeptide Ymentioning

confidence: 97%

Physiology of Kidney Renin

Castrop

Höcherl

Kurtz

et al. 2010

Physiological Reviews

234

277

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The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which is relevant under both physiological and pathophysiological settings. The kidney is the only organ capable of releasing enzymatically active renin. Although the characteristic juxtaglomerular position is the best known site of renin generation, renin-producing cells in the kidney can vary in number and localization. (Pro)renin gene transcription in these cells is controlled by a number of transcription factors, among which CREB is the best characterized. Pro-renin is stored in vesicles, activated to renin, and then released upon demand. The release of renin is under the control of the cAMP (stimulatory) and Ca2+(inhibitory) signaling pathways. Meanwhile, a great number of intrarenally generated or systemically acting factors have been identified that control the renin secretion directly at the level of renin-producing cells, by activating either of the signaling pathways mentioned above. The broad spectrum of biological actions of (pro)renin is mediated by receptors for (pro)renin, angiotensin II and angiotensin-( 1 – 7 ).

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“…However, the study does not address the connection or lack thereof between increased ischaemic myocardial angiogenesis, with unchanged blood flow achieved by NPY treatment. In addition to its effects on angiogenesis and myocardial function, NPY also activates diuretic and natriuretic properties in vivo (Refs 52, 85, 86) and promotes the clearance of water and electrolytes by increasing the release of ANP from isolated rat left atrium (Ref. 87).…”

Section: Diabetes Heart and Neuropeptidesmentioning

confidence: 99%

Diabetic neuropathy and heart failure: role of neuropeptides

Ejaz

LoGerfo

Pradhan

2011

Expert Rev. Mol. Med.

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Cardiovascular autonomic neuropathy (CAN), in which patients present with damage of autonomic nerve fibres, is one of the most common complications of diabetes. CAN leads to abnormalities in heart rate and vascular dynamics, which are features of diabetic heart failure. Dysregulated neurohormonal activation, an outcome of diabetic neuropathy, has a significant pathophysiological role in diabetes-associated cardiovascular disease. Key players in neurohormonal activation include cardioprotective neuropeptides and their receptors, such as substance P (SP), neuropeptide Y (NPY), calcitonin-gene-related peptide (CGRP), atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). These neuropeptides are released from the peripheral or autonomic nervous system and have vasoactive properties. They are further implicated in cardiomyocyte hypertrophy, calcium homeostasis, ischaemia-induced angiogenesis, protein kinase C signalling and the renin–angiotensin–aldosterone system. Therefore, dysregulation of the expression of neuropeptides or activation of the neuropeptide signalling pathways can negatively affect cardiac homeostasis. Targeting neuropeptides and their signalling pathways might thus serve as new therapeutic interventions in the treatment of heart failure associated with diabetes. This review discusses how neuropeptide dysregulation in diabetes might affect cardiac functions that contribute to the development of heart failure.

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Role of neuropeptide Y in the regulation of kidney function

Cited by 12 publications

References 62 publications

Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease

Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease

Physiology of Kidney Renin

Diabetic neuropathy and heart failure: role of neuropeptides

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