Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease

Chen, Xinyi; Du, Yifeng; Chen, Lei

doi:10.3389/fnmol.2018.00493

Cited by 81 publications

(69 citation statements)

References 121 publications

(139 reference statements)

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“…Another cause of changes in the number and neurochemical coding of nerve fibers identified in the present study may be the pro-inflammatory properties of BPA, which influence the number of T and B lymphocytes and levels of pro-inflammatory cytokines, including cytokines IL-1β, IL-6, and TNF-α [ 55 ]. However, all neuronal substances included in the present study are involved in pro- or anti-inflammatory reactions.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

Rytel

Gonkowski

2020

IJMS

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Bisphenol A (BPA) is one of the most common environmental pollutants among endocrine disruptors. Due to its similarity to estrogen, BPA may affect estrogen receptors and show adverse effects on many internal organs. The reproductive system is particularly vulnerable to the impact of BPA, but knowledge about BPA-induced changes in the innervation of the uterus is relatively scarce. Therefore, this study aimed to investigate the influence of various doses of BPA on nitrergic nerves supplying the uterus with the double immunofluorescence method. It has been shown that even low doses of BPA caused an increase in the number of nitrergic nerves in the uterine wall and changed their neurochemical characterization. During the present study, changes in the number of nitrergic nerves simultaneously immunoreactive to substance P, vasoactive intestinal polypeptide, pituitary adenylate cyclase-activating peptide, and/or cocaine- and amphetamine-regulated transcript were found under the influence of BPA. The obtained results strongly suggest that nitrergic nerves in the uterine wall participate in adaptive and/or protective processes aimed at homeostasis maintenance in the uterine activity under the impact of BPA.

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Section: Discussionmentioning

confidence: 99%

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

Rytel

Gonkowski

2020

IJMS

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“…Pauses were labelled when the centroid's velocity falls under 0.01 mm/s for more than half of all time points in a 10 s sliding time window. The animal's behavioral state was classified as a turn if, for any given time point, the geometric angle between the points behind or ahead the track by 0.3 mm is <80°2 9 . Any time points after the turn in which the velocity remains smaller than 0.1 mm/s were also classified as turn 77 .…”

Section: Discussionmentioning

confidence: 99%

“…Neuropeptides are an ancient and diverse class of secreted messengers that have recently been recognized as modulators of learning circuits 5,7,8 . This has fueled research into peptidergic systems as potential therapeutic targets for cognitive disorders 9,10 . While some neuropeptides have been implicated in experience-dependent plasticity, uncovering their actions in learning circuits has remained a challenge, in part because many neuropeptides signal extrasynaptically and interact with other neuromodulatory pathways 11,12 .…”

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confidence: 99%

Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit

et al. 2020

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Learning and memory are regulated by neuromodulatory pathways, but the contribution and temporal requirement of most neuromodulators in a learning circuit are unknown. Here we identify the evolutionarily conserved neuromedin U (NMU) neuropeptide family as a regulator of C. elegans gustatory aversive learning. The NMU homolog CAPA-1 and its receptor NMUR-1 are required for the retrieval of learned salt avoidance. Gustatory aversive learning requires the release of CAPA-1 neuropeptides from sensory ASG neurons that respond to salt stimuli in an experience-dependent manner. Optogenetic silencing of CAPA-1 neurons blocks the expression, but not the acquisition, of learned salt avoidance. CAPA-1 signals through NMUR-1 in AFD sensory neurons to modulate two navigational strategies for salt chemotaxis. Aversive conditioning thus recruits NMU signaling to modulate locomotor programs for expressing learned avoidance behavior. Because NMU signaling is conserved across bilaterian animals, our findings incite further research into its function in other learning circuits.

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“…PACAP has been identified in the hypothalamo–hypophyseal system [ 1 ] and its protective role has been shown in several pathological CNS disorders, such as ischemia [ 43 ], spinal cord injury [ 44 ], inflammation [ 45 ], peripheral nerve regeneration [ 46 ] and retinopathy [ 47 ]. PACAP has been shown to ameliorate morphological and behavioral signs of Parkinson’s disease [ 48 ] and has a protective role in AD [ 49 ]. PACAP also plays a protective role in aging, proven by the accelerated aging in various tissues of KO mice [ 15 , 50 ] but not in testis where delayed aging of testicular cells was demonstrated [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Alzheimer’s Disease Mouse as a Model of Testis Degeneration

Szegeczki

Horváth

Perényi

et al. 2020

IJMS

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Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis and in sperm motility. In the present study, we explored testicular degenerative alterations in a mouse model of Alzheimer’s disease (AD) (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) and demonstrated changes in PACAP-regulated signaling pathways. In addition, the effects of increased physical activity of AD (trained AD (TAD)) mice on testis were also followed. Reduced cell number and decreased thickness of basement membrane were detected in AD samples. These changes were compensated by physical activity. Expression of PACAP receptors and canonical signaling elements such as PKA, P-PKA, PP2A significantly decreased in AD mice, and altered Sox transcription factor expression was also detected. Via this signaling mechanism, physical activity compensated the negative effects of AD on the expression of type IV collagen. Our findings suggest that the testes of AD mice can be a good model of testis degeneration. Moreover, it can be an appropriate organ to follow the effects of various interventions such as physical activity on tissue regeneration and signaling alterations.

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Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease

Cited by 81 publications

References 121 publications

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus

Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit

Alzheimer’s Disease Mouse as a Model of Testis Degeneration

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