Neuropharmacological effects of Nigerian honey in mice

Abstract

Honey is a natural sweet substance that bees produce by transforming flower nectar or other sweet secretions of plants. It has widespread use in traditional medicine in various parts of the world. It has been reported to assist in building the entire central nervous system. The beneficial effects of honey have been attributed to the possible polyphenolic contents and some other constituents. The geographical locations and the sources of plant nectars may contribute to the effects of honey samples. Thus, we evaluated the neuropharmacological effects of six samples of honey (10%, 20% and 40% V /v, p.o.) from three geographical locations of Nigeria using the following behavioral models: Novelty-induced behaviors (NIB), learning and memory, pentobarbital-induced hypnosis, anxiolytic, anticonvulsant, analgesic and antidepressant models in mice. The results showed that honey significantly (p< 0.05) decreased locomotion and rearing behaviors in NIB and amphetamine-induced locomotor activity when compared to the control group. Exploratory behavior was significantly increased in both holeboard and elevated plus maze but had no significant effect on spatial working memory. Honey sample from Umudike has significant hypnotic and anticonvulsant effects. The antinociceptive models (hot plate and tail flick tests) showed that the honey samples significantly increased the pain reaction time and naloxone blocked these central antinociceptive effects. The force swimming test showed that only the Idanre (ID) honey sample had antidepressant effect. In conclusion, some of these honey samples have central inhibitory property, anxiolytic, antinociceptive, anticonvulsant and antidepressant effects, thus may be used as nutraceutic. It can also be inferred that some of these effects are probably mediated through dopaminergic and opioidergic systems.

Evaluating the Effects of Chronic Administration of Natural Honey on the Development of Dependence on Morphine in the Male Rats

“…31 Also, some studies showed that the NHO could induce inhibitory effects on locomotion only at high doses. 32 Morphine is known as one of the significant opioids, and the possibility of its addiction is high. Previous studies on opioids, especially morphine have shown that long-term use of morphine stimulated glia cells in the spinal and supra-spinal cord, 33 and immune system and increased production of pro-inflammatory cytokines such as IL-1β, 6 and TNF-α , as well as the occurrence of neuroinflammation.…”

Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats

“…Nectar conceivably has beneficial shrewdness of morphine-induced oxidative stress, to be able to enhance the reliance and tolerance in opiate dependency, human beings, some other contemplate designated that lessening in oxidative stress in opiate addicts will lower dependence and withdrawal indications 7 . We as a great deal as this time precise that nectar fortifies a vital antinociceptive impact 16 and has a positive impact on morphine analgesia and can be a sturdy association with pain control 17 . Withdrawals from opiates can cause digestive problems which include nausea and diarrhea similarly to muscle pain and anxiety.…”

Production of GABA‐enriched honey syrup using Lactobacillus bacteria isolated from honey bee stomach

“…In many investigations, the therapeutic effect of honey has been proven to improve or prevent diseases' progression (in humans and animals), in which some of them are recorded as follows: antifungal, antibacterial, and antiviral (Anthimidou & Mossialos, ; Candiracci et al, ; León‐Ruiz et al, ), antioxidant (Alves, Ramos, Gonçalves, Bernardo, & Mendes, ; Nayik & Nanda, ), radioprotective (Ahmad et al, ), prebiotic, and probiotic (Ammar, Ismail, Khalil, & Eid, ; Bakr, Mohamed, Tammam, & El‐Gazzar, ), antidepressant and anxiolytic (Akanmu et al, ; Al‐Rahbi, Zakaria, Othman, Hassan, & Ahmad, ), anti‐osteoporosis (Mohd Effendy, Mohamed, Muhammad, Mohamad, & Shuid, ), cardioprotective (Khalil, Tanvir, Afroz, Sulaiman, & Gan, ), and antitumor (Ahmed & Othman, ; Erejuwa, Sulaiman, & Wahab, ).…”