Neuropharmacological screening of Diospyros mespiliformis in mice

Adzu, Bulus; Amos, Samson; Muazzam, I.; Inyang, Uford S.; Gamaniel, K.

doi:10.1016/s0378-8741(02)00249-0

Cited by 29 publications

(14 citation statements)

References 29 publications

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“…OS did not cause alteration in motor coordination on the rotarod test in the protocol studied, suggesting that the decreased locomotor action observed may not be exerted through peripheral neuromuscular blockage or centrally mediated impairment of motor function (Adzu et al, 2002).…”

Section: Discussionmentioning

confidence: 72%

Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression

Chatterjee

Verma

Maurya

et al. 2011

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 72%

Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression

Chatterjee

Verma

Maurya

et al. 2011

Pharmaceutical Biology

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“…Animals were observed for 30 minutes to detect the onset of spasm and generalized tonic-clonic seizures and further up to 2 hr to detect mortality if any [20] animals devoid of seizures were considered as protected [21]. In this model of seizure, also it was found that there was no mortality of rats in any of the groups, and the maximum anticonvulsant activity was found with the 200 mg/kg dose.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant Activity of Citrus Maximus Leaves in Experimental Animal Models

Thakuria¹,

Das²,

Dewan³

2016

Asian J Pharm Clin Res

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Objective: To assess the anticonvulsant activity of ethanolic extract of Citrus maximus (EECM) leaves of maximal electroshock seizure (MES) and pentylenetetrazol (PTZ)-induced seizure models on albino (Wistar strain) rats and mice.Methods: Anticonvulsant activity was carried out by MES model and PTZ-induced clonic convulsions model; in each model, albino rats (Wistar strain) of either sex were taken and divided into five groups, each consisting of 6 rats. One group was used as control (3% w/v gum acacia), one as standard (phenytoin), and three groups for the test drug of EECM leaves (doses of 50, 100, and 200 mg/kg) treatment. The reduction in time or abolition of tonic extensor phase of MES-convulsions was recorded for all the animals. In PTZ model, either delay or complete abolition of convulsions in rats treated with diazepam and EECM leaves was noted for all the animals.Result: EECM leaves reduced the extensor phase of convulsion in MES in a dose-dependent manner and decrease in the duration of convulsions in PTZ model with increasing dose. Anticonvulsant activity was seen maximum at the dose of 200 mg/kg. Conclusions:Thus, from the above two seizure models of MES and PTZ, it can be concluded that EECM leaves have got an anticonvulsant effect in an increasing dose-dependent manner.

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“…The rotarod test was performed (n=6) to examine the possible neurological deficits caused by the test compounds, which could give rise to false positives, such as muscle relaxant or impairment of the motor coordination (20).…”

Section: Behavioral Testsmentioning

confidence: 99%