Neurophysiological distinction between schizophrenia and schizoaffective disorder

Mathalon, Daniel H.

doi:10.3389/neuro.09.070.2009

Cited by 30 publications

(34 citation statements)

References 48 publications

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“…We assessed the transient GBR elicited by the standard tones presented as part of a three-stimulus auditory oddball task, described in more detail elsewhere (Ford et al, 2008, Mathalon et al, 2010). The high probability (p=.7) standard stimuli were 500Hz, 50 ms tones presented with a stimulus-onset asynchrony of 1.25 sec 210 times over the course of the task.…”

Section: Methodsmentioning

confidence: 99%

Converging evidence for gamma synchrony deficits in schizophrenia

Roach

Ford

Hoffman

et al. 2013

Supplements to Clinical Neurophysiology

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Background In electroencephalogram (EEG) studies of auditory steady-state responses (ASSR), patients with schizophrenia show a deficit in power and/or phase-locking, particularly at the 40Hz frequency where these responses resonate. In addition, studies of the transient gamma band response (GBR) elicited by single tones have revealed deficits in gamma power and phase-locking in schizophrenia. We examined the degree to which the 40 Hz ASSR and the transient GBR to single tones are correlated and whether they assess overlapping or distinct gamma band abnormalities in schizophrenia. Methods EEG was recorded during 40 Hz ASSR and auditory oddball paradigms from 28 patients with schizophrenia or schizoaffective disorder (SZ) and 25 age- and gender-matched healthy controls (HC). The ASSR was elicited by 500 ms click trains, and the transient GBR was elicited by the standard tones from the oddball paradigm. Gamma phase and magnitude values, calculated using Morlet Wavelet transformations, were used to derive total power and phase-locking measures. Results Relative to HC, SZ patients had significant deficits in total gamma power and phase-locking for both ASSR- and GBR-based measures. Within both groups, the 40 Hz ASSR and GBR phase-locking measures were significantly correlated, with a similar trend evident for the total power measures. Moreover, co-varying for GBR substantially reduced 40 Hz ASSR power and phase-locking differences between the groups. Conclusions 40 Hz ASSR and transient GBR measures provide very similar information about auditory gamma abnormalities in schizophrenia, despite the overall enhancement of 40 Hz ASSR total power and phase-locking values relative to the corresponding GBR values.

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Section: Methodsmentioning

confidence: 99%

Converging evidence for gamma synchrony deficits in schizophrenia

Roach

Ford

Hoffman

et al. 2013

Supplements to Clinical Neurophysiology

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“…All EEG processing was performed as described previously (Mathalon et al, 2010). Briefly, EEG data from 3 midline sites (Fz, Cz and Pz) were analyzed.…”

Section: Erp Analysesmentioning

confidence: 99%

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

D’Souza

Fridberg

Skosnik

et al. 2012

Neuropsychopharmacol

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Cannabinoids induce a host of perceptual alterations and cognitive deficits in humans. However, the neural correlates of these deficits have remained elusive. The current study examined the acute, dose-related effects of delta-9-tetrahydrocannabinol (D 9 -THC) on psychophysiological indices of information processing in humans. Healthy subjects (n ¼ 26) completed three test days during which they received intravenous D 9 -THC (placebo, 0.015 and 0.03 mg/kg) in a within-subject, double-blind, randomized, cross-over, and counterbalanced design. Psychophysiological data (electroencephalography) were collected before and after drug administration while subjects engaged in an event-related potential (ERP) task known to be a valid index of attention and cognition (a three-stimulus auditory 'oddball' P300 task). -THC-induced perceptual alterations. Lastly, exploratory analyses examining cannabis use status showed that whereas recent cannabis users had blunted behavioral effects to D 9 -THC, there were no dose-related effects of D 9 -THC on P300a/b amplitude between cannabis-free and recent cannabis users. Overall, these data suggest that at doses that produce behavioral and subjective effects consistent with the known properties of cannabis, D 9-THC reduced P300a and P300b amplitudes without altering the latency of these ERPs. Cannabinoid agonists may therefore disrupt cortical processes responsible for context updating and the automatic orientation of attention, while leaving processing speed and earlier sensory ERP components intact. Collectively, the findings suggest that CB1R systems modulate top-down and bottom-up processing.

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“…Amplitude decrease has been shown in chronic schizophrenia patients (Devrim-Ucok et al, 2006; Mathalon et al, 2010) and in clinical high risk (Jahshan et al, 2012; Mondragon-Maya et al, 2013). In recent onset subjects, amplitude deficits ( Valkonen-Korhonen et al, 2003b; Hermens et al, 2010; Kaur et al, 2011; Jahshan et al, 2012), but also a lack of them, have been reported (Frodl et al, 2001b; Devrim-Ucok et al, 2006; Atkinson et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Clinical high risk and first episode schizophrenia: Auditory event-related potentials

Spencer

Oribe

et al. 2015

Psychiatry Research: Neuroimaging

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The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n=21), first episode schizophrenia patients (FESZ, n=20) and matched healthy controls (HC, n=25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership.

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Neurophysiological distinction between schizophrenia and schizoaffective disorder

Cited by 30 publications

References 48 publications

Converging evidence for gamma synchrony deficits in schizophrenia

Converging evidence for gamma synchrony deficits in schizophrenia

Dose-Related Modulation of Event-Related Potentials to Novel and Target Stimuli by Intravenous Δ9-THC in Humans

Clinical high risk and first episode schizophrenia: Auditory event-related potentials

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