Neurophysiological Features of the Nociceptive Trigeminal Pathway in Abdominally Obese Migraineurs

Нікіфорова, Олена Сергіївна; Delva, M. Yu.

doi:10.36740/wlek202004109

Cited by 7 publications

(6 citation statements)

References 30 publications

(26 reference statements)

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“…13 Obesity also seems to interfere with the frequency 14,15 , duration and intensity of migraine symptoms 16 , in addition, it can increase the susceptibility of migraine to chronicity. 17,18 Recent studies prove this relationship and suggest some mechanisms for the interaction between the two diseases, such as inflammation 19 , persistent states of hyperleptinemia 20 , irregular hypothalamic function and sympathetic dysregulation. 21 Considering the above, the scientific literature was reviewed in order to better understand the mechanisms of interaction between obesity and migraine, in addition to their clinical implications and the consequences for the health of the individuals affected by both diseases.…”

Section: Introductionmentioning

confidence: 92%

“…This may explain, at least partially, the more frequent and severe headaches in individuals with obesity 21 and how these changes in the trigeminal nociceptive pathway cause central sensitization, which favors the evolution of the disease from its episodic to chronic form. 17 Adipokines produced by adipose tissue, leptin and adiponectin, have also been shown to be related to migraine.…”

Section: Asaamentioning

confidence: 99%

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The association between obesity and migraine and possible mechanisms of action: an integrative literature review

Halaiko

Faro

Levis

et al. 2021

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IntroductionObesity is a multifactorial disease and is defined by the excessive accumulation of adipose tissue that can cause harm to human health. The presence of obesity is an important risk factor for migraine chronification. However, not much is known about the link between the two diseases. MethodsIn this study, an integrative literature review was conducted to better understand the mechanisms of interaction between migraine and obesity. Therefore, a search of PubMed and the Virtual Health Library (VHL) was performed with the following keywords: enxaqueca e obesidade; enxaqueca e obesidade e inflamação; enxaqueca e obesidade e neuropeptídeos; migraine and obesity; migraine and obesity and inflammation; migraine and obesity and neuropeptides. ResultsThe search identified 22 articles. After reading and analyzing the articles, three thematic categories emerged: 1) Obesity as an Aggravating Factor for Migraine 2) Mechanisms Studied between Obesity and Migraine 3) The Effect of Weight Loss on Migraine Symptoms. ConclusionsThe chronic low-grade inflammation associated with obesity can cause a predisposition to migraine chronification. The abnormal secretion of adipokines, dysregulation of the sympathetic nervous system, and hypothalamic dysfunction have been suggested to be the main shared mechanisms between both diseases.

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Section: Introductionmentioning

confidence: 92%

Section: Asaamentioning

confidence: 99%

The association between obesity and migraine and possible mechanisms of action: an integrative literature review

Halaiko

Faro

Levis

et al. 2021

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show abstract

“…Загалом, взаємозв'язки між ГБ та психо-емоційними порушеннями вважаються складними та двонаправленими: ГБН первинно може бути джерелом тривожно-депресивних розладів, які в свою чергу посилюють ГБН та сприяють в подальшому його прогресуванню. [15,16]. Ймовірно, наявність АО у пацієнтів з ЕГБН також сприяє механізмам розвитку центральної сенситизаціїзокрема, у пацієнтів з ХГБН при нейрофізіологічних дослідженнях виявлено посилення процесів фасилітації тригемінальної ноцицептивної системи [17], а при нейровізуалізаційних дослідженнях -достовірне зменшення кількості сірої речовини в кортикальних областях, відповідальних за сприйняття болю [18].…”

Section: результати та їх обговоренняunclassified

“…Окрім базових функціональних тестів, у світі використовуються новітні методи оцінки якості товщини ліпідного шару (ТЛШ), якості водномуцинового шару, стабільності слізної плівки: інтерферометрія, меніскометрія та неінвазивний час розриву слізної плівки відповідно [1,2,6,7,9,11,14,15]. Однак, має місце недостатнє висвітлення проблеми змін специфічних якісних характерстик слізної плівки у користувачів цифрових пристроїв, що аргументує доцільність проведення сучасних досліджень.…”

Section: вступunclassified

Socio-Demographic and Comorbid Characteristics of Patients With Tension Headache

Delva

2021

Act. Probl. of the Modern Med.

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Introduction. Chronic tension headache is a significant medical and social challenge. There are many factors, which interact resulting in the chronicity of tension headache. The aim of the study was to investigate social, demographic and comorbid characteristics of the patients with frequent episodic tension headache and chronic tension headache. Material and methods. We examined 93 patients with frequent episodic tension headache and 34 patients with chronic tension headache. We analyzed patients’ sex, age, marital status, educational level, employment, smoking habits, anxiety and depressive disorders (according to the Hospital Anxiety and Depression Scale), migraine, musculoskeletal pains (cervical and lower back), arterial hypertension, diabetes mellitus, abdominal obesity, and history of traumatic brain injury. Results. The patients with chronic tension headache in comparison with the patients having frequent episodic tension headache had significantly more common (p <0.05) having no family (47% vs. 23%), smokers (35% vs. 16%), had significantly more common anxiety disorders (82% vs. 27%), depressive disorders (79% vs. 27%), abdominal obesity (41% vs. 13%) and episodes of lower back pain during the last calendar year (53% vs. 22%). Conclusions. Timely identification and adequate correction of lifestyle and some conditions (smoking, anxiety and depressive disorders, abdominal obesity) as well as pathogenetically grounded treatment of lower back pain in the patients with frequent episodic tension headache may reduce the risk of headache chonicity.

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“…Not only general practitioners but also many neurologists till now misunderstand the mechanism of PH, considering PH as a symptom of another disease. On the other hand, very often headache sufferers after ineffective consultations lose confidence in doctors and begin to self-medicate [6,7]. So, for improvement of PH management it is necessary to provide a thorough analysis of typical errors in PH diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Primary Headaches Management in Poltava Regions

Delva

2021

Wiad Lek

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The aim: Assess quality of diagnosis and treatment of primary headaches (PH) in Poltava region. Materials and methods: There were examined 195 patients with PH who were previously consulted by different specialists due to headaches. We analyzed previously established diagnoses, previous consultations and prescribed investigations due to headache, drugs that were prescribed for headache treatment. Results: The misdiagnoses of PH were made due to considering the headache as secondary (as sign of dyscirculatory encephalopathy, arterial hypertension, autonomic dysfunction, cervical ostheochondrosis). Patients older 40 years were misdiagnosed more often with dyscirculatory encephalopathy, while patients under 40 years were more frequently misdiagnosed with autonomic dysfunctions. Patients sought medical help for headache problem and were repeatedly examined by different specialists (general practitioner, neurologist, cardiologist, ophthalmologist, oyorhinolaryngologist, neurosurgeon). Doctors prescribed a large number of identical uninformative neuroimaging and neurofunctional methods regardless of PH nosologies. Also it had been often prescribed therapy with the use of vascular, metabolic, nootropic drugs without specific pathogenetic effects for PH. Conclusions: It is necessary to improve the diagnosis and treatment of PH according to international standards by raising awareness among general practitioners, neurologists and other specialists about the basics of PH diagnosis and treatment.

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Neurophysiological Features of the Nociceptive Trigeminal Pathway in Abdominally Obese Migraineurs

Cited by 7 publications

References 30 publications

The association between obesity and migraine and possible mechanisms of action: an integrative literature review

The association between obesity and migraine and possible mechanisms of action: an integrative literature review

Socio-Demographic and Comorbid Characteristics of Patients With Tension Headache

Analysis of Primary Headaches Management in Poltava Regions

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